ID F6PTY9_HORSE Unreviewed; 242 AA.
AC F6PTY9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=small monomeric GTPase {ECO:0000256|ARBA:ARBA00011984};
DE EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
GN Name=RASL11A {ECO:0000313|Ensembl:ENSECAP00000008633.2,
GN ECO:0000313|VGNC:VGNC:22207};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008633.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000008633.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008633.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000008633.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008633.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000256|ARBA:ARBA00023421};
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000256|ARBA:ARBA00008344}.
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DR RefSeq; XP_001491637.1; XM_001491587.3.
DR AlphaFoldDB; F6PTY9; -.
DR SMR; F6PTY9; -.
DR STRING; 9796.ENSECAP00000008633; -.
DR PaxDb; 9796-ENSECAP00000008633; -.
DR Ensembl; ENSECAT00000011091.4; ENSECAP00000008633.2; ENSECAG00000012858.3.
DR GeneID; 100051189; -.
DR KEGG; ecb:100051189; -.
DR CTD; 6144; -.
DR VGNC; VGNC:22207; RASL11A.
DR GeneTree; ENSGT00940000161208; -.
DR HOGENOM; CLU_103610_0_1_1; -.
DR InParanoid; F6PTY9; -.
DR OMA; INYGDYV; -.
DR OrthoDB; 148212at2759; -.
DR TreeFam; TF314640; -.
DR Proteomes; UP000002281; Chromosome 17.
DR Bgee; ENSECAG00000010661; Expressed in inner cell mass and 23 other cell types or tissues.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR CDD; cd04146; RERG_RasL11_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45704; RAS-LIKE FAMILY MEMBER 11; 1.
DR PANTHER; PTHR45704:SF3; RAS-LIKE PROTEIN FAMILY MEMBER 11A; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
SQ SEQUENCE 242 AA; 26943 MW; 239E327FFD0749F3 CRC64;
MRPPTMSGHF LLAPIPESSS DYLLPKDIRL AVLGAGRVGK SAMIVRFLTK RFIGDYEPNT
GKLYSRLVCV EGDQLSLQIQ DTPGGIQVQD NLTQLVDSLS KCVQWAEGFL LVYSITDHDS
YQAIRPLYQH IRKVHPDSKA PVIIVGNKGD LLHARQVQTH DGIQLANELG SLFLEISTSE
NYEDVCVVFQ HLCKEVSKLH SLSGERRRAS IIPRPRSPNM QDLKRRFKQA LSSKGKAPSA
LG
//
