ID F6PV98_HORSE Unreviewed; 1235 AA.
AC F6PV98;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN Name=EIF5B {ECO:0000313|Ensembl:ENSECAP00000022904.4,
GN ECO:0000313|VGNC:VGNC:17512};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022904.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022904.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022904.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022904.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022904.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR AlphaFoldDB; F6PV98; -.
DR STRING; 9796.ENSECAP00000022904; -.
DR PaxDb; 9796-ENSECAP00000022904; -.
DR Ensembl; ENSECAT00000028890.4; ENSECAP00000022904.4; ENSECAG00000000102.5.
DR VGNC; VGNC:17512; EIF5B.
DR GeneTree; ENSGT00940000162583; -.
DR HOGENOM; CLU_002656_0_1_1; -.
DR InParanoid; F6PV98; -.
DR OMA; EFAVMLC; -.
DR TreeFam; TF101535; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000000102; Expressed in trophectoderm and 23 other cell types or tissues.
DR ExpressionAtlas; F6PV98; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 644..861
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..528
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..584
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1235 AA; 140172 MW; 46CCCF765293A533 CRC64;
MGKKQKNKSE DSAKDDADLD ALAAEIEGAG AAKEQEPQKS KGKKKKEKKR QDFDEDDILK
ELEELSWEAQ GIKADREAAA VKVKDQSGYH SCFLVPVPTE NNEEESTSKQ DKKKKGQKGK
KQSFDDNDSE ELEDKDSKSK KTAKPKVEMC SGSDDDDDFN KLSKKAKGKA QKSNKKWDGS
EEDEDNSKRI KERSRVNSSG ESGDESDEFL QSRKGQKKNQ KNKPGPNVES GNEEDDSSFK
IKTMAQKKAE KKERERKKRD EEKAKLRKLK EKEELETGKK DQSKQKESQK KSEEEPVKSK
VTLDAGAAPA SEEKGETPTA AEDDNEGDKK KKDKKKKKGE KEEKEKEKKK GPSKATVKAM
QEALAKLKEE EERQKREEEE RIKRLEELEA KRKEEERLEQ EKRERKKQKE KERKERLKKE
GKLLTKSQRE ARARAEATLK LLQAQGVEVP SKDSLPKKRP IYEDKKKKKT PPQLENKEVS
EPTELSAAVE VVEQGVPEKE ETPPPVEPEE EEETEDTGLD DWEAMASDEE REQEGNTVHI
EVKENPEEEE EEEEDEEEEE DSEEEEEEEG ESEGSEGDEE DEKVSDEKDA GKTLDKKSSK
ELSSESEYDS DDDRTKEERA YDKAKRRIEK RRLEHSKNVN TEKLRAPIIC VLGHVDTGKT
KILDKLRHTH VQDGEAGGIT QQIGATNVPL EAINEQTKMI KNFDRENVRI PGMLIIDTPG
HESFSNLRNR GSSLCDIAIL VVDIMHGLEP QTIESINLLK SKKCPFIVAL NKIDRLYDWK
KSPDSDVAAT LKKQKKNTKD EFEERAKAII VEFAQQGLNA ALFYENKDPR TFVSLVPTSA
HTGDGMGSLI YLLVELTQTM LNKRLAHCEE LRAQVMEVKA LPGMGTTIDV ILINGRLKEG
DTIIVPGVEG PIVTQIRGLL LPPPMKELRV KNQYEKHKEV EAAQGVKILG KDLEKTLAGL
PLLVAYKEDE IPVLKDELIH ELKQTLNAIK LEEKGVYVQA STLGSLEALL EFLKTSEVPY
AGINIGPVHK KDVMKASVML EHDPQYAVIL AFDVRIERDA QEMADSLGVR IFSAEIIYHL
FDAFTKYRQD YKKQKQEEFK HIAVFPCKMK ILPQYIFNSR DPIVIGVTVE AGQVKQGTPM
CVPSKNFVDI GVVTSIEINH KQVDVAKKGQ EVCVKIEPIP GESPKMYGRH FEATDILVSK
ISRQSIDALK DWFRDEMQKS DWQLIVELKK VFEII
//
