ID F6PWF7_PIG Unreviewed; 403 AA.
AC F6PWF7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
GN Name=KRT33A {ECO:0000313|Ensembl:ENSSSCP00000018483.3};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000018483.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000018483.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000018483.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000018483.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; F6PWF7; -.
DR SMR; F6PWF7; -.
DR STRING; 9823.ENSSSCP00000018483; -.
DR PaxDb; 9823-ENSSSCP00000018483; -.
DR PeptideAtlas; F6PWF7; -.
DR Ensembl; ENSSSCT00000018988.3; ENSSSCP00000018483.3; ENSSSCG00000030350.4.
DR eggNOG; ENOG502SNBF; Eukaryota.
DR GeneTree; ENSGT00940000153980; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; F6PWF7; -.
DR OMA; ACNISAN; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF332742; -.
DR Reactome; R-SSC-6805567; Keratinization.
DR Reactome; R-SSC-6809371; Formation of the cornified envelope.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000030350; Expressed in anatomical structure and 3 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF97; KERATIN, TYPE I CUTICULAR HA1; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F6PWF7};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 55..366
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 59..93
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 158..203
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 250..351
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 403 AA; 45801 MW; 288A6D3F9CEBAA18 CRC64;
MPYNCLPNLS CRSSSSSRPC VPSSCQGITL PGACNIPATV SSGNWFCEGA FNGNEKETMQ
FLNDRLASYL EKVRQLERDN AELERQIQER SQQQEPLVCP NYQSYFRTIE ELQQKILCSK
SENARLVVQI DNAKLASDDF RTKYETELGL RQLVESDLNG LRRILDELTL CKADLEAQVE
SLKEELLCLK QNHEQEVNSL RSQLGDRLNI EVDAAPTVDL NSVLSETRSQ YEALVETNRR
DVEEWFTRQT EELNKQVVSS SEQLQSYQAE IIELRRTVNA LEVELQAQHN LRDSLENTLT
ETEARYSSQL AQVQGLIGNV EAQLAEIRAD LERQNQEYQV LLDVRARLEC EINTYRGLLE
SEDCKLPCNP CATTNAYEKT VGPCVSNPCV SRTWCGPCNT LVR
//
