ID F6Q7S0_HORSE Unreviewed; 791 AA.
AC F6Q7S0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Terminal nucleotidyltransferase 4A {ECO:0000313|Ensembl:ENSECAP00000008104.2};
GN Name=TENT4A {ECO:0000313|Ensembl:ENSECAP00000008104.2,
GN ECO:0000313|VGNC:VGNC:54561};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008104.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000008104.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008104.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000008104.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008104.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; F6Q7S0; -.
DR SMR; F6Q7S0; -.
DR STRING; 9796.ENSECAP00000008104; -.
DR PaxDb; 9796-ENSECAP00000008104; -.
DR Ensembl; ENSECAT00000010494.3; ENSECAP00000008104.2; ENSECAG00000010134.3.
DR VGNC; VGNC:54561; TENT4A.
DR GeneTree; ENSGT00940000157811; -.
DR HOGENOM; CLU_013572_3_0_1; -.
DR InParanoid; F6Q7S0; -.
DR OMA; KWGSRVH; -.
DR TreeFam; TF313939; -.
DR Proteomes; UP000002281; Chromosome 21.
DR Bgee; ENSECAG00000010134; Expressed in inner cell mass and 23 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0031499; C:TRAMP complex; IBA:GO_Central.
DR GO; GO:0070568; F:guanylyltransferase activity; IEA:Ensembl.
DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR GO; GO:0060212; P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR GO; GO:1905870; P:positive regulation of 3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0071076; P:RNA 3' uridylation; IEA:Ensembl.
DR GO; GO:0031123; P:RNA 3'-end processing; IBA:GO_Central.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002058; PAP_assoc.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR InterPro; IPR045862; Trf4-like.
DR PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR PANTHER; PTHR23092:SF24; TERMINAL NUCLEOTIDYLTRANSFERASE 4A; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF03828; PAP_assoc; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 264..372
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 427..486
FT /note="PAP-associated"
FT /evidence="ECO:0000259|Pfam:PF03828"
FT REGION 96..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 791 AA; 84567 MW; 56D3C31FE34CABB9 CRC64;
MDPRVAWIQP EQKGPANALW MQIWETSQGV GRGGSGFASY FCLNSPALDT AAAAGAAGLG
GGGLAGPALP AASPPPPAPG PAALPPALLT ALGPAAEGAR RLHKSPSLSS SSSSSSNAES
GTESPGCSSS SSSSASLGRA GGGRGGAFFH FADGPPSAPG AANGHPGPRG PAPAGSPPPH
QFHPGRRKRE NKASTYGLNY LLSGSRAAAL SGGGGPGPQA PRPGTPWKSR AYSPGIQGLH
EEIIDFYNFM SPCPEEAAMR REVVKRIETV VKDLWPTADV QIFGSFSTGL YLPTSDIDLV
VFGKWERPPL QLLEQALRKH NVAEPCSIKV LDKATVPIIK LTDQETEVKV DISFNMETGV
RAAEFIKNYM KKYSLLPYLI LVLKQFLLQR DLNEVFTGGI SSYSLILMAI SFLQLHPRID
ARRADENLGM LLVEFFELYG RNFNYLKTGI RIKEGGAYIA KEEIMKAMTS GYRPSMLCIE
DPLLPGNDVG RSSYGAMQVK QVFDYAYIVL SHAVSPLARS YPNRDSESTL GRIIKVTQEV
IDYRRWIKEK WGSKAHPAPD LDNRIKIKER VSACDGEQPQ RRDPESPYSQ RLALSLPSPQ
LLSSGSSASS VSSLSGSDID SDTPPCTTPS VYQFSLQAPT PLLAGLPAAL PMPSGKPQPT
TSRTLVMTTN TQTRFTLPPP TLGVAPVPCR QVGVEGTPAL KAVHHLSSPA IPSASPNPLS
SPHLYHKQHS GMKLSMKGSH NHSQGGSYSS VGSGGVRPPV GNRGHHQYNR TGWRRKKHTH
TRDSLPVSLS R
//