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Database: UniProt
Entry: F6Q7S0_HORSE
LinkDB: F6Q7S0_HORSE
Original site: F6Q7S0_HORSE 
ID   F6Q7S0_HORSE            Unreviewed;       791 AA.
AC   F6Q7S0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=Terminal nucleotidyltransferase 4A {ECO:0000313|Ensembl:ENSECAP00000008104.2};
GN   Name=TENT4A {ECO:0000313|Ensembl:ENSECAP00000008104.2,
GN   ECO:0000313|VGNC:VGNC:54561};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008104.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000008104.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008104.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000008104.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008104.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   AlphaFoldDB; F6Q7S0; -.
DR   SMR; F6Q7S0; -.
DR   STRING; 9796.ENSECAP00000008104; -.
DR   PaxDb; 9796-ENSECAP00000008104; -.
DR   Ensembl; ENSECAT00000010494.3; ENSECAP00000008104.2; ENSECAG00000010134.3.
DR   VGNC; VGNC:54561; TENT4A.
DR   GeneTree; ENSGT00940000157811; -.
DR   HOGENOM; CLU_013572_3_0_1; -.
DR   InParanoid; F6Q7S0; -.
DR   OMA; KWGSRVH; -.
DR   TreeFam; TF313939; -.
DR   Proteomes; UP000002281; Chromosome 21.
DR   Bgee; ENSECAG00000010134; Expressed in inner cell mass and 23 other cell types or tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0031499; C:TRAMP complex; IBA:GO_Central.
DR   GO; GO:0070568; F:guanylyltransferase activity; IEA:Ensembl.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0060212; P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR   GO; GO:1905870; P:positive regulation of 3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0071076; P:RNA 3' uridylation; IEA:Ensembl.
DR   GO; GO:0031123; P:RNA 3'-end processing; IBA:GO_Central.
DR   CDD; cd05402; NT_PAP_TUTase; 1.
DR   Gene3D; 1.10.1410.10; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002058; PAP_assoc.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   InterPro; IPR045862; Trf4-like.
DR   PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR   PANTHER; PTHR23092:SF24; TERMINAL NUCLEOTIDYLTRANSFERASE 4A; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   Pfam; PF03828; PAP_assoc; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          264..372
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          427..486
FT                   /note="PAP-associated"
FT                   /evidence="ECO:0000259|Pfam:PF03828"
FT   REGION          96..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        734..751
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   791 AA;  84567 MW;  56D3C31FE34CABB9 CRC64;
     MDPRVAWIQP EQKGPANALW MQIWETSQGV GRGGSGFASY FCLNSPALDT AAAAGAAGLG
     GGGLAGPALP AASPPPPAPG PAALPPALLT ALGPAAEGAR RLHKSPSLSS SSSSSSNAES
     GTESPGCSSS SSSSASLGRA GGGRGGAFFH FADGPPSAPG AANGHPGPRG PAPAGSPPPH
     QFHPGRRKRE NKASTYGLNY LLSGSRAAAL SGGGGPGPQA PRPGTPWKSR AYSPGIQGLH
     EEIIDFYNFM SPCPEEAAMR REVVKRIETV VKDLWPTADV QIFGSFSTGL YLPTSDIDLV
     VFGKWERPPL QLLEQALRKH NVAEPCSIKV LDKATVPIIK LTDQETEVKV DISFNMETGV
     RAAEFIKNYM KKYSLLPYLI LVLKQFLLQR DLNEVFTGGI SSYSLILMAI SFLQLHPRID
     ARRADENLGM LLVEFFELYG RNFNYLKTGI RIKEGGAYIA KEEIMKAMTS GYRPSMLCIE
     DPLLPGNDVG RSSYGAMQVK QVFDYAYIVL SHAVSPLARS YPNRDSESTL GRIIKVTQEV
     IDYRRWIKEK WGSKAHPAPD LDNRIKIKER VSACDGEQPQ RRDPESPYSQ RLALSLPSPQ
     LLSSGSSASS VSSLSGSDID SDTPPCTTPS VYQFSLQAPT PLLAGLPAAL PMPSGKPQPT
     TSRTLVMTTN TQTRFTLPPP TLGVAPVPCR QVGVEGTPAL KAVHHLSSPA IPSASPNPLS
     SPHLYHKQHS GMKLSMKGSH NHSQGGSYSS VGSGGVRPPV GNRGHHQYNR TGWRRKKHTH
     TRDSLPVSLS R
//
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