ID F6Q818_HORSE Unreviewed; 772 AA.
AC F6Q818;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Arachidonate 15-lipoxygenase type B {ECO:0000313|Ensembl:ENSECAP00000010415.3};
GN Name=ALOX15B {ECO:0000313|Ensembl:ENSECAP00000010415.3,
GN ECO:0000313|VGNC:VGNC:15262};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010415.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010415.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010415.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010415.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010415.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962,
CC ECO:0000256|RuleBase:RU003974};
CC -!- SIMILARITY: Belongs to the lipoxygenase family.
CC {ECO:0000256|RuleBase:RU003974}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6Q818; -.
DR STRING; 9796.ENSECAP00000010415; -.
DR PaxDb; 9796-ENSECAP00000010415; -.
DR Ensembl; ENSECAT00000013152.4; ENSECAP00000010415.3; ENSECAG00000012112.4.
DR VGNC; VGNC:15262; ALOX15B.
DR GeneTree; ENSGT00940000161510; -.
DR HOGENOM; CLU_004282_3_3_1; -.
DR InParanoid; F6Q818; -.
DR OMA; LHINMLA; -.
DR TreeFam; TF105320; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000012112; Expressed in zone of skin and 16 other cell types or tissues.
DR ExpressionAtlas; F6Q818; baseline.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0050473; F:arachidonate 15-lipoxygenase activity; IBA:GO_Central.
DR GO; GO:0036403; F:arachidonate 8(S)-lipoxygenase activity; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0005506; F:iron ion binding; IEA:Ensembl.
DR GO; GO:0016165; F:linoleate 13S-lipoxygenase activity; IEA:Ensembl.
DR GO; GO:1990136; F:linoleate 9S-lipoxygenase activity; IEA:Ensembl.
DR GO; GO:0019369; P:arachidonic acid metabolic process; IBA:GO_Central.
DR GO; GO:1901696; P:cannabinoid biosynthetic process; IEA:Ensembl.
DR GO; GO:0071926; P:endocannabinoid signaling pathway; IEA:Ensembl.
DR GO; GO:0051122; P:hepoxilin biosynthetic process; IBA:GO_Central.
DR GO; GO:0043651; P:linoleic acid metabolic process; IBA:GO_Central.
DR GO; GO:0034440; P:lipid oxidation; IBA:GO_Central.
DR GO; GO:2001303; P:lipoxin A4 biosynthetic process; IEA:Ensembl.
DR GO; GO:0019372; P:lipoxygenase pathway; IBA:GO_Central.
DR GO; GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045926; P:negative regulation of growth; IEA:Ensembl.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
DR GO; GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; IEA:Ensembl.
DR CDD; cd01753; PLAT_LOX; 1.
DR Gene3D; 3.10.450.60; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR InterPro; IPR020834; LipOase_CS.
DR InterPro; IPR020833; LipOase_Fe_BS.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042062; PLAT_LOX_verte.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF161; POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15B; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR Pfam; PF01477; PLAT; 1.
DR PRINTS; PR00087; LIPOXYGENASE.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS00711; LIPOXYGENASE_1; 1.
DR PROSITE; PS00081; LIPOXYGENASE_2; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964, ECO:0000256|RuleBase:RU003974};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU003974};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003974};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003974};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 2..125
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 125..772
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
SQ SEQUENCE 772 AA; 86554 MW; C8AB09D28A5DFD33 CRC64;
MAKYRVRVST GEAFGAGTWD KMSITIVGTQ GETPRLPLDH LGKEFTVGAE EDFEVKSPQD
VGPVLLLRVH KAPPALPLLL GPLAPDAWFC RSFQLTPPRG SLLRFPAYQW LEGAGSLVLR
EGAAKVSWAD HHPKLQQQRR EELQARQEMY RWKTYQPGWP HCLDMETVKD LDLNTKYSVV
KSTNLYLRAQ SAFAELKIKG LLERKGSWRS LSEMEMVLNF QKTPATGDKS GSRRTSYEAL
VVVSRGWWPQ QSSDSRDGVD RWTCPQDGES VGCDEKRKRG PQALPQQPGG WRCHFPGCQA
MGGAGLKEEP TFSLRYAAFE AEYVFEHWQE DAFFASQFLN GLNPVLIHRC RRLPENFPVT
DAMVAPVLGP GTSLQAELER GSLFLVDHGI LSGVRTNVIN GRPQFSAAPM TLLYQCPGHG
LLLPLAIQLS QTPGPNSPIF LPSDDKWDWL LAKTWVRNAD FSVHEALTHL LHTHLLSEVF
VLATLRQLPH CHPLFKLLVP HTRYTLHINT LARELLITPK RVVDRSTGLG LRGFSELIQR
SMEQLNYSVL CLPEDIRARG VEDIPGYYYR DDGMQIWGAV EHFVSEIIGI YYPSDVSVRD
DSELQAWVWE IFSKGFLGRE SSGLPSSLET REALVQYVTM VIFNCSAKHS AVGSGQFDYC
AWMPNLPPSM QLPPPTSKGQ ASLEGFIATL PPVNASCDVI IALWLLSKEP GDQRPLGTYP
EEHFTEEASR QSIAAFQSRL AQISQDIRVR NQGLVLPYTY LDPPLIESSI SI
//
