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Database: UniProt
Entry: F6Q8C4_HORSE
LinkDB: F6Q8C4_HORSE
Original site: F6Q8C4_HORSE 
ID   F6Q8C4_HORSE            Unreviewed;      2223 AA.
AC   F6Q8C4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 43.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSECAP00000010405};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010405, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000010405, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010405,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000010405}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010405};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000010405}.
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DR   PaxDb; F6Q8C4; -.
DR   Ensembl; ENSECAT00000013141; ENSECAP00000010405; ENSECAG00000011838.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000002281; Chromosome 25.
DR   Bgee; ENSECAG00000011838; -.
DR   ExpressionAtlas; F6Q8C4; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF246; PTHR10037:SF246; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     41     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     73     93       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    128    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    205    226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    238    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    389    409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    415    432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    453    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    536       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    592    614       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1039   1057       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1077   1097       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1109   1127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1170   1192       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1282   1307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1363   1381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1393   1419       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1486   1504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1572   1595       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1611   1646       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      617    643       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2223 AA;  248907 MW;  701D3FE6D4E8A04C CRC64;
     PFEYMILATI IANCIVLALE QHLPDGDKTP MSERLDDTEP YFIGIFCFEA GIKILALGFV
     LHKGSYLRNG WNVMDFVVVL TGILATAGTD FDLRTLRAVR VLRPLKLVSG IPSLQVVLKS
     IMKAMVPLLQ IGLLLFFAIL MFAIIGLEFY MGKFHKACFS NSTDADPVGD FPCGKEAPAR
     LCEGDTECRE YWPGPNFGIT NFDNILFAIL TVFQCITMEG WTDILYNTND AAGNTWNWLY
     FIPLIIIGSF FMLNLVLGVL SGEFAKERER VENRRAFLKL RRQQQIEREL NGYLEWIFKA
     EEVMLAEEDK NAEEKSPLDV LKRAATKKSR NDLIHAEEGE DRFADLCAVG SPFARASLKS
     GKTESSSYFR RKEKMFRFFI RRMVKAQSFY WVVLCVVALN TVCVAMVHYN QPQRLTTALY
     FAEFVFLGLF LTEMSLKMYG LGPRSYFRSS FNCFDFGVIV GSIFEVVWAA IKPGTSFGIS
     VLRALRLLRI FKVTKYWNSL RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF
     NFEDETPTTN FDTFPAAILT VFQILTGEDW NAVMYHGIES QGGVSKGMFS SFYFIVLTLF
     GNYTLLNVFL AIAVDNLANA QELTKDEEEM EEAANQKLAL QKAKEVAEVS PMSAANISIA
     AKGEGGAKAS PAWGSCSSSP RLVNAGTHTH SRSHVHSHTR SCSFSHIHTH PDTHSHIWRP
     VGAKSGGGGL FGIVGQVGQL QASLLQPGGD VPSLVERHRV RDQRGPNCSV ARTEQPRGQG
     QAESSTKEER LVHRMRPSRE EASGATNAGC SVVRRRHRRG SPEEAAEREP RRHRAHRLAP
     DQGKEGERRA RHRGPRAGPR EAESGEEPAR RHRARHKALP AHEDAEKEAA ERESGVEDRD
     KDKELRNHQP REPHCDLEAT GIMGVGPVHA LPSTCLQKVE EQPEDADNQR NVTRMGSQPS
     DPSTTVPIPV MLTGPPGETT VVPSGNVDLE SQAEGKKEVE ADDVMRSGPR PIVPYSSMFC
     LSPTNLLRRF CHYIVTMRYF EMVILVVIAL SSIALAAEDP VRTDSPRNNA LKYMDYIFTG
     VFTFEMVMKM IDLGLLLHPG AYFRDLWNIL DFIVVSGALV AFAFSGSKGK DINTIKSLRV
     LRVLRPLKTI KRLPKLKAVF DCVVNSLKNV LNILIVYMLF MFIFAVIAVQ LFKGKFFYCT
     DESKELERDC RGQYLDYEKE EVEAQPRQWK KYDFHYDNVL WALLTLFTVP REEGGPWVLK
     HSVDATYEEQ GPSPGYRMEL SIFYVVYFVV FPFFFVNIFV ALIIITFQEQ GDKVMSECSL
     EKNERACIDF AISAKPLTRY MPQNKQSFQY KTWTFVVSPP FEYFIMAMIA LNTVVLMMKF
     YDAPYEYELM LKCLNIVFTS MFSMECVLKI IAFGVLNYFR DAWNVFDFVT VLGSITDILV
     TEIAETNNFI NLSFLRLFRA ARLIKLLRQG YTIRILLWTF VQSFKALPYV CLLIAMLFFI
     YAIIGMQVFG NIALDDDTSI NRHNNFRTFL QALMLLFRSA TEEAWHEIML SCLNQACDEH
     ANASECGSDF AYFYFVSFIF LCSFLMLNLF VAVIMDNFEY LTRDSSILGP HHLDEFIRVW
     AEYDPAACGR ISYSDMFEML KHMSPPLGLG KKCPARVAYK RLVRMNMPIS NEDMTVHFTS
     TLMALIRTAL EIKLAPAGTK QHQCDAELRK EISSVWANLP QKTLDLLVPP HKPDEMTVGK
     VYAALMIFDF YKQNKTTRDQ IHQAPGGLSQ MGPVSLFHPL KATLEQTQPA VLRGARVFLR
     QKSSASLSNG GAVQTQESGI KESVSWGTQR TQEGPYEART PLERGHSAEI PVVQPGKSAV
     DVQMQSMALR GPDGEPQPGL ESQGRAASMP RLAAETQPAP DASPMKRSIS TLAPQRSHVA
     HLCTAALDRA PASQAPHHHH RCHRRRDRKQ KSLEKGPSLS ADTDGAPSST AGPGPPLAEG
     PAGCRRERRQ ERGRSQERRQ PSSSSSEKQR FYSCDRFGGR EPPQPKPALG SHPTSPTAGQ
     EPGPPRQGGG SVNGSPLLST SGASTPGRGG RRKLPQTPLT PRPSITYKTA NSSPVHFTGA
     QTSLPAFSPG RLSRGLSEHN ALLQRDPLSQ PLAPGSRIGS DPYLGQRLDS EAAARTQPED
     TLTFEEAVAT NSGRSSRTSY VSSLTSQSHP LRRVPNGYHC TLGLSSGSRA RHSYHHPDQD
     HWC
//
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