ID F6QC73_HORSE Unreviewed; 2204 AA.
AC F6QC73;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=KIAA0100 {ECO:0000313|Ensembl:ENSECAP00000015741.3};
GN Name=KIAA0100 {ECO:0000313|VGNC:VGNC:19354};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015741.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015741.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015741.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015741.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015741.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000019247.3; ENSECAP00000015741.3; ENSECAG00000017711.4.
DR VGNC; VGNC:19354; KIAA0100.
DR GeneTree; ENSGT00600000084481; -.
DR HOGENOM; CLU_000926_1_0_1; -.
DR TreeFam; TF314307; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000017711; Expressed in synovial membrane of synovial joint and 23 other cell types or tissues.
DR ExpressionAtlas; F6QC73; baseline.
DR InterPro; IPR019443; BLTP2/FMP27/Hobbit_C.
DR InterPro; IPR048872; BLTP2_RBG6.
DR InterPro; IPR019441; FMP27/BLTP2/Hobbit_GFWDK_RBG.
DR InterPro; IPR019439; FMP27/BLTP2_N.
DR InterPro; IPR045167; Hobbit.
DR PANTHER; PTHR15678; ANTIGEN MLAA-22-RELATED; 1.
DR PANTHER; PTHR15678:SF6; PROTEIN KIAA0100; 1.
DR Pfam; PF21675; BLTP2_RBG-6; 1.
DR Pfam; PF10351; FMP27-BLTP2_C; 1.
DR Pfam; PF10344; FMP27-BLTP2_N; 2.
DR Pfam; PF10347; Fmp27_GFWDK; 1.
DR SMART; SM01214; Fmp27_GFWDK; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1026..1158
FT /note="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit"
FT /evidence="ECO:0000259|SMART:SM01214"
FT REGION 1493..1527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2042..2062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1812..1877
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2204 AA; 249937 MW; C6CF0BE9DB9404D9 CRC64;
MPLFFSAVLA LLLVALSALF LGRWLVVRLA TKWCQRKLQA ELKIGSFFWI QNVSLKFQQH
QQTVEIDSLW ISSKLLSHDL PHYVALCFGE VRIRTDLQKV SGLFAPFSQS AGAHQKELSF
SPSLLKIFCQ LFSIHVDSIN IMVLKVATSE SLWHIQIRES SFLLDSDGKR LKCEVSLSQI
NSKVLKSGQL EDTCLAELSL ALKLCLEVGL NSWQLKAVTV DVWTLHAELH EGLFHSQLLR
QGSHLAPKPI PCSEETENLA EPTLPGLYLL QQLPDQVQVK MEVTSVVLSM NSQKRHLNWT
LKLLHFLYHR DEDQLPLRSF TANSDMAQMS TELLLKDGLL LSQSRQRIVC LNSLKASVQV
TTIDLSASLV LNTCIIHYRH QEFSHWLHMV ALETQASSSS VFKQREKRTF PQILAPIIFS
TSISNVNISI QLGDTPPFAL GFNSICLDYQ HLRPQSIHQR GVLTVDHLCW RVGSDSHIQR
APHPPNMHVW GEALVLDSFT LQGSYNQPLG LSSTQSDTLF LDCTIRGLQV EASDTCAQCL
SRILFLMGPQ SGKSAVSRES SLGESVSLLW KVDLKVEDMN LFTLSALVGA SEVRLDTLTV
LGSAETSTVG IQGLVLALVK SVTEKMQPCC KAPDIPTPVL SLSMLSITYH SSIRSLEVQC
GTGLTLLWSP PDHMYLYQHI LATLQCRDLL RATLFSKTVP PLALETPGTT SEPEGCLPEP
SPPKRLLNLA LEVSTAKLTA FVAEDKFITL AAESVSLSRH GGSLQAYCPE LAAGFDGNSI
FNFKEVELQL LPELEEMILH RNPFPVLQTL RNRVWLLSLG SLSVEFPYQY DFSRTLDEAV
GVQKWLKGLH QGTRAQASPS LAPLPPDLLL KVQHFSWVFL DDIFEVKLRD NYELMKDESK
ESAKRLQLLD AKVAALRKQH GELLPARKIE ELYASLEHKN IEIYIQRSRR LYGNTPMRRA
LLTWSLVGLE LVALADASFH GPERVVEQVR ELDPGSPFPA EGVDLVIHWC RMLKCSVKTF
LVRIRDYPRY LFEIHDWRLM GRLVGTEQSG QPCSRRRQIL HLGLPWGNVA VERNMPPLKF
YHDFHSEIFQ YTVVWGPCWD PAWTLIGQSV DLLTKPSADP SPPLPWWDKS RLLFHGDWHM
DIEQANLHQL ATEDPYNTTE NMHWEWSHLS FHWKPGQFVF KGDLDVNVRT ASKYDDCCFL
HLPDLCMTLD LQWLCHGNPY DHHGVTLRAP EFLPEVPLGQ LHDSYRAFRS ENLNLSIKMD
LTQHSGTISQ PRILLYSSTL RWMQNFWATW TSVTRPICRG KLFNNLKPSK KKLGQHYKQL
SYTALFPQLQ VHYWASFAQQ RGIQIECSQG HVFTRGTQRL IPQAGTVMRR LISDWSVTQM
VSDLSQVTVH LMASPTEENA DHCLDPLVTK THLLSLSSLT YQRHSSRMAE EELSTRVGDP
AFHTHQLHLV DLRASWTTTN RDIAFGLYDG YKKAAVLKRN LSTEALKGLK IDPQMPAKKP
KQSILTSAPA PPPVSTPSFS GQPDKGSSGG AYMLQKLIEE TDRFVVFTEE ESGVSDQLCG
IAACQTDDIY NRNCLIELVN CQMVLRGAET EGCVIVSAAK AQLLQCQHHP AWYGDTLKQK
TSWTCLLDGM QYFATTESSP TEQDGRQLWL EVKNIEEHRQ RSLDSVQELM ESGQAVGGMV
TTTTDWNQPA EAQQAQQVQR IISRCNCRMY YISYSHDIDP ELATQIKPPE VHENQEKEDL
LKKQEGAVDT FTLIHHELEI STNPAQYAMI LDIVNNLLLH VEPKRKEHSE KKQRVRFQLE
ISSNPEEQRS SILHLQEAVR QHVAQIRQLE KQMYSIMKSL QDDSKNENLL DLNQKLQLQL
NQEKANLQLE SEELNILIRC FKDFQLQQAN KMELRKQQED VSVVRRTEFY FAQARWCLTE
EDGQLGIAEL ELQRFLYSKV VLRPQSSCQS GRQLALRLFS KVRPPVGGIS VKEHFEVNVV
PLTIQLTHQF FHRIMGFFFP GRSVEDDEVG DEEDKSKLVT TGIPVVKPRQ LIPTDDAAPL
GPGKGVAQGL NRSSGVRRSF RKAPEHPVDD IDKMKERAAM NNSFIYIKIP QVPLCVSYKG
EKNSVDWGDL NLVLPCLEYH NNTWTWLDFA MAVKRDSRRA LVAQVIKEKL RLKPATGSEV
RGKLETKSDL NMQQQEEEEK ARLLIGLSVG NKNPGKKSIF GRRK
//
