ID F6QD32_MACMU Unreviewed; 1812 AA.
AC F6QD32; F6QD66;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Myosin VA {ECO:0000313|Ensembl:ENSMMUP00000009867.4};
GN Name=MYO5A {ECO:0000313|Ensembl:ENSMMUP00000009867.4,
GN ECO:0000313|VGNC:VGNC:75116};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000009867.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000009867.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000009867.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR SMR; F6QD32; -.
DR Ensembl; ENSMMUT00000010516.4; ENSMMUP00000009867.4; ENSMMUG00000007509.4.
DR VEuPathDB; HostDB:ENSMMUG00000007509; -.
DR VGNC; VGNC:75116; MYO5A.
DR GeneTree; ENSGT00940000155347; -.
DR HOGENOM; CLU_000192_9_2_1; -.
DR Proteomes; UP000006718; Chromosome 7.
DR Bgee; ENSMMUG00000007509; Expressed in Ammon's horn and 23 other cell types or tissues.
DR ExpressionAtlas; F6QD32; baseline.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd15478; Myo5a_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037988; Myo5a_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 6.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 6.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 1..52
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 61..755
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1491..1767
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 591..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..657
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1099..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 907..1090
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1147..1174
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1296..1396
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 155..162
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1812 AA; 210237 MW; A951044A85229C46 CRC64;
MFARVWIPDP EEVWKSAELL KDYKPGDKVL LLHLEEGKDL EYRLDPKTKE LPHLRNPDIL
VGENDLTALS YLHEPAVLHN LRVRFIDSKL IYTYCGIVLV AINPYEQLPI YGEDIINAYS
GQNMGDMDPH IFAVAEEAYK QMARDERNQS IIVSGESGAG KTVSAKYAMR YFATVSGSAS
EANVEEKVLA SNPIMESIGN AKTTRNDNSS RFGKYIEIGF DKRYRIIGAN MRTYLLEKSR
VVFQAEEERN YHIFYQLCAS AKLPEFKMLR LGNADDFNYT QQGGSPVIEG VDDAKEMAHT
RQACTLLGIS ESHQMGIFRI LAGILHLGNV GFTSRDADSC TIPPKHEPLC IFCDLMGVDY
EEMCHWLCHR KLATATETYI KPISKLQATN ARDALAKHIY AKLFNWIVDN VNQALHSAVK
QHSFIGVLDI YGFETFEINS FEQFCINYAN EKLQQQFNMH VFKLEQEEYM KEQIPWTLID
FYDNQPCINL IESKLGILDL LDEECKMPKG TDDTWAQKLY NTHLNKCTLF EKPRLSNKAF
IIQHFADKVE YQCEGFLEKN KDTVFEEQIK VLKSSKFKML PELFQDDEKA ISPTSATSSG
RTPLTRIPAK PIKGRPGQMA KEHKKTVGHQ FRNSLHLLME TLNATTPHYV RCIKPNDFKF
PFTFDEKRAV QQLRACGVLE TIRISAAGFP SRWTYQEFFS RYRVLMKQKD VLSDRKQTCK
NVLEKLILDK DKYQFGKTKI FFRAGQVAYL EKLRADKLRA ACIRIQKTIR GWLLRKKYLR
MRKAAITVQR YVRGYQARCY AKFLRRTKAA TIIQKYWRMF VVCRRYKIRR AATIVLQSYL
RGFLARNRYR KILREHKAVI IQKRVRGWLA RTHYKRSMHA IIYLQCCFRR MMAKRELKKL
KIEARSVERY KKLHIGMENK IMQLQRKVDE QNKDYKCLVE KLTNLEGIYN SETEKLRSDL
ERLQLSEEEA KVATGRVLSL QEEIAKLRKD LEQTRSEKKC IEERADQYKQ ETEQLVSNLK
EENTLLKQEK EALNHRIVEQ AKEMTETMEK KLVEETKQLE LDLNDERLRY QNLLNEFSRL
EERYDDLKEE MTLMVHVPKP GHKRTDSTHS SNESEYTFSS EIAEMEDIPS RTEEPSEKKV
PLDMSLFLKL QKRVTELEQE KQVMQDELDR KEEQVLRSGA LCPFQQSFPY EKSAPEVTAP
GAPAYRVLME QLTSVSEELD VRKEEVLILR SQLVSQKEAI HPKNTMTDST ILLEDVQKMK
DKGEIAQAYI GLKETNRSSA LDYRELNEDG ELWLVYEGLK QANRLLESQL QSQKRSHENE
AEALRGEIQS LKEENNRQQQ LLAQNLQLPP EARIEASLQH EITRLTNENL DLMEQLEKQD
KTVRKLKKQL KVFAKKIGEL EVGQMENISP GQIIDEPIRP VNIPRKEKDF QGMLEYKKED
EQKLVKNLIL ELKPRGVAVN LIPGLPAYIL FMCVRHADYL NDDQKVRSLL TSTINSIKKV
LKKRGDDFET VSFWLSNTCR FLHCLKQYSG EEGFMKHNTS RQNEHCLTNF DLAEYRQVLS
DLAIQIYQQL VRVLENILQP MIVSGMLEHE TIQGVSGVKP TGLRKRTSSI ADEGTYTLDS
ILRQLNSFHS VMCQHGMDPE LIKQVVKQMF YIVGAITLNN LLLRKDMCSW SKGMQIRYNV
SQLEEWLRDK NLMNSGAKET LEPLIQAAQL LQVKKKTDDD AEAICSMCNA LTTAQIVKVL
NLYTPVNEFE ERVSVSFIRT IQMRLRDRKD SPQLLMDAKH IFPVTFPFNP SSLALETIQI
PASLGLGFIS RV
//
