ID F6QKE4_MOUSE Unreviewed; 1221 AA.
AC F6QKE4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Immunoglobulin-like and fibronectin type III domain containing 1 {ECO:0000313|Ensembl:ENSMUSP00000119230.3};
DE Flags: Fragment;
GN Name=Igfn1 {ECO:0000313|Ensembl:ENSMUSP00000119230.3,
GN ECO:0000313|MGI:MGI:3045352};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119230.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000119230.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119230.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000119230.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119230.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR ProteomicsDB; 324305; -.
DR Antibodypedia; 34499; 109 antibodies from 15 providers.
DR Ensembl; ENSMUST00000124134.3; ENSMUSP00000119230.3; ENSMUSG00000051985.13.
DR AGR; MGI:3045352; -.
DR MGI; MGI:3045352; Igfn1.
DR VEuPathDB; HostDB:ENSMUSG00000051985; -.
DR GeneTree; ENSGT00940000162073; -.
DR HOGENOM; CLU_006405_2_0_1; -.
DR ChiTaRS; Igfn1; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000051985; Expressed in quadriceps femoris and 12 other cell types or tissues.
DR ExpressionAtlas; F6QKE4; baseline and differential.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR040849; MyBP-C_THB.
DR PANTHER; PTHR13817:SF73; PROTEIN SIDEKICK HOMOLOG; 1.
DR PANTHER; PTHR13817; TITIN; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF18362; THB; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Proteomics identification {ECO:0007829|ProteomicsDB:F6QKE4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 67..157
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 348..420
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 629..724
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 729..828
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 830..925
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 929..1013
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1026..1120
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1134..1221
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 806..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 227..254
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000119230.3"
FT NON_TER 1221
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000119230.3"
SQ SEQUENCE 1221 AA; 134866 MW; B59DD066060264C7 CRC64;
XVSREGWSDS NPGYRKQFIC RPQEIGFHSE EHREAGTMAA KPPKKSSIPG VSIRQLVDEI
PEGCSTPDFK QKPVTLALPE GKNAIFRAVV CGEPRPEVHW QSSKGDLSNS AKYQISSAPG
REEHVLQINK LTGEDSDLYR CTALNAYGEA TCSVRLTVIE VGFRKNRKRQ KEPQEDLRKE
LMDFRKMLKK RAPPPTPEKK MESEQVWQLL VTADRKDYEK ICMQYGIVDF RGMLRKLQEM
KKEQEDRMAQ YVSAIANLRH IKVTKEGVAT FDLELDLKNL ESKIYLYKDG EMIPYGVDNQ
TKHCLRRLGK RYHFQIQDLR PEDAGLYQVM VEDAVVFSTE LESRTIPPRV VVPLAETRCE
ERGDAVFECT LSNPCPSATW HFQHRPLRLS DKYEVFVSPD GLTHRLVVKG ASSSDMGLYS
LNTGLHASSA WLVVEGSMDH FSQGLTDTEV QLGEAAIVSC TLASDLGPGT WFKDGVKLTA
QDGVIFEQDG LTHRLILTHV EGTQAGKYTF VAGCQHSEAS LTVQDPPTIA PDVTETLREP
LVFKAGKPVT VKIPFQSRLP VQAAWRKDGN EVVGGDHKGI QLALADGYTW LCLPSVCRKD
SGRYSVTLRS EGGCVQAEFT LQVIDKPQPP QGPLEVQDCH RAGVCLRWLP PRDNGGQVIQ
HYVVERRQAG RSTWLKVGEP PSDSTSFTDT SVEQGKKYAF RVRAVTSVGA GDALESEEVL
VAPEALPGPP SAPAILSASS QSITLTWGAP QGPGSNHILG YLIEKHKKGS NTWMAVNEQP
VSERRYTVVG LRQGCQYEFR VTAVTLSGPG DPGPPSDAVF ARDPMRPPGP VRDLQVTDTS
NTSITVSWMV PDARDADEAQ GYIVELCGSD SHQWSPCHVG TVPGTTFTAK GLRPQEGYFV
RVTAVNDGGR SQATSLDTLV HAMPATVCPR FLMDSGTKDT LMVRVGDSIR VPLSFEAAPM
PEVTWLKDGL PLPKRSVTTV KAGLTQLLIP AASLSDCGRY TVMLRNLQGK EATHSFFINV
AACPQAPGSI YLQENVPGTV TVQWEPSPDE AQGIPLHYTV LMRSSSHRSW HEVADHVRTN
RFTLLGVLPG HEYHFRVLAK NELGVSKPSD TSQPWCIPRQ RDRFTVKSPT YQDPDLSQKP
RFLVGLRAHL LPQGCECRMT CAVQGSPQPH VTWFKNDQSL DRNPAVYSTD LLGVCSLVIP
SVSLKDSGEY KAVAKNPLGQ A
//
