GenomeNet

Database: UniProt
Entry: F6QN38_MACMU
LinkDB: F6QN38_MACMU
Original site: F6QN38_MACMU 
ID   F6QN38_MACMU            Unreviewed;      4940 AA.
AC   F6QN38;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   22-NOV-2017, entry version 43.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSMMUP00000001421};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSMMUP00000001421};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000001421, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000001421, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001421,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000001421}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001421};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000001421}.
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DR   EMBL; JSUE03003670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000001510; ENSMMUP00000001421; ENSMMUG00000001060.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000006718; Chromosome 1.
DR   Bgee; ENSMMUG00000001060; -.
DR   ExpressionAtlas; F6QN38; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4262   4281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4482   4502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4556   4575       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4683   4704       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4741   4762       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4817   4840       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    270       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      276    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      589    799       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1015   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1327   1552       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4005   4040       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4394   4427       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4940 AA;  561137 MW;  ADD6CC3CA3C24E7C CRC64;
     MLSDHSDSGE EDDEVVLQCT ATIHKEQQKL CLAAEGFGNR LCFLESTSNS KNVPPDLSIC
     TFVLEQSLSV RALQEMLANT VEKSEGQVDV EKWTAQGGGH RTLLYGHAIL LRHSYSGMYL
     CCLSTSRSST DKLAFDVGLQ EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER
     YLHLSYGNGS LHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG
     EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV TTGKYLSLME
     DKNLLLMDKE KADVKSTAFT FRSSKEKLDV GVRKEVDGMG TSEIKYGDSV CYIQHVDTGL
     WLTYQSVDVK SVRMGSIQRK AIMHHEGHMD DGISLSRSQH EESRTARVIR STVFLFNRFI
     RGLDALSKKA KATTVDLPIE SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ
     EEGMINLVLE CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ
     FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL LDKHGRNHKV
     LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN HVSSMRPNIF LGVSEGSAQY
     KKWYYELMVD HTEPFVTAEA THLRVGWAST EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL
     HLWSGCIART VSSPNQHLLR TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP
     VVSFSAGIKV RFLLGGRHGE FKFLPPPGYA PCYEAVLPKE KLKVEHSREY KQERTYTRDL
     LGPTVSLTQA AFTPIPVDTS QIVLPPHLER IREKLAENIH ELWVMNKIEL GWQYGPVRDD
     NKRQHPCLVE FSKLPEQERN YNLQMSLETL KTLLALGCHV GISDEHAEDK VKKMKLPKNY
     QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA ENAHNVWARD RIRQGWTYGI QQDVKNRRNP
     RLVPYTLLDD RTKKSNKDSL REAVRTLLGY GYNLEAPDQD HAARAEVCSG TGERFRIFRA
     EKTYAVKAGR WYFEFETVTA GDMRVGWSRP GCQPDQELGS DERAFAFDGF KAQRWHQGNE
     HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG FIPVCSLGVA
     QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW LSKRLPQFLQ VPSNHEHIEV
     TRIDGTIDSS PCLKVTQKSF GSQNSHTDIM FYRLSMPIEC AEVFSKTVAG GLPGAGLFGP
     KNDLEDYDAD SDFEVLMKTA HGHLVPDRVD KDKEATKPEF NNHKDYAQEK PSRLKQRFLL
     RRTKPDYSTS HSARLTEDVL ADDRDDYDFL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF
     HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR NNNGLEIGCV
     VDAASGLLTF IANGKELSTY YQVEPSTKLF PAVFAQATSP NVFQFELGRI KNVMPLSAGL
     FKSEHKNPVP QCPPRLHVQF LSHVLWSRMP NQFLKVDVSR ISERQGWLVQ CLDPLQFMSL
     HIPEENRSVD ILELTEQEEL LKFHYHTLRL YSAVCALGNH RVAHALCSHV DEPQLLYAIE
     NKYMPGLLRA GYYDLLIDIH LSSYATARLM MNNEYIVPMT EETKSITLFP DENKKHGLPG
     IGLSTSLRPR MQFSSPSFVS VSNECYQYSP EFPLDILKAK TIQMLTEAVK EGSLHARDPV
     GGTTEFLFVP LIKLFYTLLI MGIFHNEDLK HILQLIEPSV FKEAATPEEE SDTLEKELSV
     DDAKLQGAGE EEAKGGKRPK EGLLQMKLPE PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD
     DFVAKLQDNQ RFRYNEVMQA LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKSECPCPE
     EIRDQLLDFH EDLMTHCGIE LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK KKQAEKPVES
     DSKKSSTLQQ LISETMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR ALPKTYTING
     VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN LMRALGMHET
     VMEVMVNVLG GGESKEITFP KMVANCCRFL CYFCRISRQN QKAMFDHLSY LLENSSVGLA
     SPAMRGSTPL DVAAASVMDN NELALALREP DLEKVVRYLA GCGLQSCQLL VSKGYPDIGW
     NPVEGERYLD FLRFAVFCNG ESVEENANVV VRLLIRRPEC FGPALRGEGG NGLLAAMEEA
     IKIAEDPSRD GPSPNSGSSK TLDTEEEEDD TIHMGNAIMT FYAALIDLLG RCAPEMHLIH
     AGKGEAIRIR SILRSLIPLG DLVGVISIAF QMPTIAKDGN VVEPDMSAGF CPDHKAAMVL
     FLDRVYGIEV QDFLLHLLEV GFLPDLRAAA SLDTAALSAT DMALALNRYL CTAVLPLLTR
     CAPLFAGTEH HASLIDSLLH TVYRLSKGCS LTKAQRDSIE VCLLSICGQL RPSMMQHLLR
     RLVFDVPLLN EHAKMPLKLL TNHYERCWKY YCLPGGWGNF GAASEEELHL SRKLFWGIFD
     ALSQKKYEQE LFKLALPCLS AVAGALPPDY MESNYVSMME KQSSMDSEGN FNPQPVDTSN
     ITIPEKLEYF INKYAEHSHD KWSMDKLANG WIYGEIYSDS SKVQPLMKPY KLLSEKEKEI
     YRWPIKESLK TMLAWGWRIE RTREGDSMAL YNRTRRISQT SQVSVDAAHG YSPRAIDMSN
     VTLSRDLHAM AEMMAENYHN IWAKKKKMEL ESKGGGNHPL LVPYDTLTAK EKAKDREKAQ
     DILKFLQING YAVSRGFKDL ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRGK
     GEHFPYEQEI KFFAKVVLPL IDQYFKNHRL YFLSAASRPL CSGGHASNKE KEMVTSLFCK
     LGVLVRHRIS LFGNDATSIV NCLHILGQTL DARTVMKTGL ESVKSALRAF LDNAAEDLEK
     TMENLKQGQF THTRNQPKGV TQIINYTTVA LLPMLSSLFE HIGQHQFGED LILEDVQVSC
     YRILTSLYAL GTSKSIYVER QRSALGECLA AFAGAFPVAF LETHLDKHNI YSIYNTKSSR
     ERAALSLPTN VEDVCPNIPS LEKLMEEIVE LAESGIRYTQ MPHVMEVILP MLCSYMSRWW
     EHGPENNPER AEMCCTALNS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA VFSQPIINKV
     KPQLLKTHFL PLMEKLKKKA AMVVSEEDHL KAEARGDMSE AELLILDEFT TLARDLYAFY
     PLLIRFVDYN RAKWLKEPNP EAEELFRMVA EVFIYWSKSH NFKREEQNFV VQNEINNMSF
     LITDTKSKMS KAAVSDQERK KMKRKGDRYS MQTSLIVAAL KRLLPIGLNI CAPGDQELIA
     LAKNRFSLKD TEDEVRDIIR SNIHLQGKLE DPAIRWQMAL YKDLPNRTDD TSDPEKTVER
     VLDIANVLFH LEQVRLCVEH PQRSKKAVWH KLLSKQRKRA VVACFRMAPL YNLPRHRAVN
     LFLQGYEKSW IETEEHYFED KLIEDLAKPG ADPPEEDEGT KRVDPLHQLI LLFSRTALTE
     KCKLEEDFLY MAYADIMAKS CHDEEDDDGE EEVKSFEEKE MEKQKLLYQQ ARLHDRGAAE
     MVLQTISASK GETGPMVAAT LKLGIAILNG GNSTVQQKML DYLKEKKDVG FFQSLAGLMQ
     SCSVLDLNAF ERQNKAEGLG MVTEEGSGEK VLQDDEFTCD LFRFLQLLCE GHNSDFQNYL
     RTQTGNNTTV NIIISTVDYL LRVQESISDF YWYYSGKDVI DEQGQRNFSK AIQVAKQVFN
     TLTEYIQGPC TGNQQSLAHS RLWDAVVGFL HVFAHMQMKL SQDSSQIELL KELMDLQKDM
     VVMLLSMLEG NVVNGTIGKQ MVDMLVESSN NVEMILKFFD MFLKLKDLTS SDTFKEYDPD
     GKGVISKRDF HKAMESHKHY TQSETEFLLS CAETDENETL DYEEFVKRFH EPAKDIGFNV
     AVLLTNLSEH MPNDTRLQTF LELAESVLNY FQPFLGRIEI MGSAKRIERV YFEISESSRT
     QWEKPQVKES KRQFIFDVVN EGGEKEKMEL FVNFCEDTIF EMQLAAQISE SDLNERSANK
     EESEKERPEE QGPRMAFFSI LTVKSALFAL RYNILTLMRM LSLKSLKKQM KKVKKMTVKD
     MVTAFFSSYW SIFMTLLHFV ASVFRGFFRI ICSLLLGGSL VEGAKKIKVA ELLANMPDPT
     QDEVRGDGEE GERKTLEAAL PSEDLTDLKE LTEESDLLSD IFGLDLKREG GQYKLIPHNP
     NAGLSDLMSN PVPMPEVQEK FQEQKAKEEE KEEKEETKSE PEKAEGEDGE KEEKAKEDKG
     KQKLRQLHTH RYGEPEVPES AFWKKIIAYQ QKLLNYFARN FYNMRMLALF VAFAINFILL
     FYKVSTSSVV EGKELPTRSS SENAKVTSLD SSSHRIIAVH YVLEESSGYM EPTLRILAIL
     HTVISFFCII GYYCLKVPLV IFKREKEVAR KLEFDGLYIT EQPSEDDIKG QWDRLPIKCF
     FSYPKVMDKY GEFYGRDRIS ELLGMDKAAL DFSDAREKKK PKKDSSLSAV LNSIDVKYQM
     WKLGVVFTDN SFLYLAWYMT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL
     VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DGDTPDMKCD DMLTCYMFHM YVGVRAGGGI
     GDEIEDPAGD EYEIYRIIFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVKEDMETK
     CFICGIGNDY FDTVPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER
     CWEFFPAGDC FRKQYEDQLN
//
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