ID F6QPA5_HORSE Unreviewed; 714 AA.
AC F6QPA5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Myogenesis regulating glycosidase (putative) {ECO:0000313|Ensembl:ENSECAP00000003234.1};
GN Name=MYORG {ECO:0000313|Ensembl:ENSECAP00000003234.1};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003234.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000003234.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003234.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000003234.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003234.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
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DR AlphaFoldDB; F6QPA5; -.
DR STRING; 9796.ENSECAP00000003234; -.
DR PaxDb; 9796-ENSECAP00000003234; -.
DR Ensembl; ENSECAT00000004660.3; ENSECAP00000003234.1; ENSECAG00000004776.3.
DR Ensembl; ENSECAT00000083009.1; ENSECAP00000064256.1; ENSECAG00000004776.3.
DR Ensembl; ENSECAT00000092135.1; ENSECAP00000082032.1; ENSECAG00000004776.3.
DR Ensembl; ENSECAT00000110678.1; ENSECAP00000076600.1; ENSECAG00000004776.3.
DR Ensembl; ENSECAT00000115860.1; ENSECAP00000067075.1; ENSECAG00000004776.3.
DR Ensembl; ENSECAT00000143056.1; ENSECAP00000064654.1; ENSECAG00000004776.3.
DR GeneTree; ENSGT00940000161008; -.
DR HOGENOM; CLU_008294_0_0_1; -.
DR InParanoid; F6QPA5; -.
DR OMA; PPWEYDS; -.
DR TreeFam; TF324266; -.
DR Proteomes; UP000002281; Chromosome 23.
DR Bgee; ENSECAG00000004776; Expressed in muscle tissue and 20 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0048741; P:skeletal muscle fiber development; IBA:GO_Central.
DR CDD; cd06592; GH31_NET37; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43053; GLYCOSIDASE FAMILY 31; 1.
DR PANTHER; PTHR43053:SF7; MYOGENESIS-REGULATING GLYCOSIDASE; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 2.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361185};
KW Hydrolase {ECO:0000256|RuleBase:RU361185};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 323..469
FT /note="Glycoside hydrolase family 31 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF01055"
FT DOMAIN 529..615
FT /note="Glycoside hydrolase family 31 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF01055"
FT DOMAIN 630..710
FT /note="Glycosyl hydrolase family 31 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21365"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 80782 MW; E47A19DFDEA80405 CRC64;
MPQKPDEKSQ AYPRRRPGSH TGRKSPEAVA AAAMYTFVPD NFSPSKPKPS KELKPLLGSA
VLGLLLVLAA VVAWCYYSAS LRKAERLRTE LLDLNRGGFS IRNQKGEQVF RLAFRSGALD
LDSCSRDGAL LGCSRTADGR PLHFFIQTVR PKDTVMCYRV RWEEAVPGRA VEHAMFLGDA
AAHWYGGAEM RTQHWPIRLD GQQEPQPFVT SDVFSSNAAF GGILERYWLS SRAAAIKVND
SVPFHLGWNS TERSLRLQAR YHDTPYKPPA GHAAAPELSY RVCVGSDVTS IHKYMVRRYF
NKPSRVPAPE AFRDPIWSTW VLYGRAVNQD KVLRLAQQIR QHRFNSSHLA IDDMYTPAYG
DFDFDEAKFP NASDMFRRLR DAGFRVTLWV HPFVNYNSSC FGEGVERELF VREPTGRLPA
LVRWWNGIGA VLDFTRPEAR DWFQGHLRRL RSRYAVASFK FDAGEVSYLP RDFSTYRPLP
DPSVWSRRYT EMALPFFSLA EVRVGYQSQN ISCFFRLVDR DSVWGYDLGL RSLIPAVLTV
SMLGYPFILP DMVGGNAVLE RTAGGGGVPE RELYVRWLEV AAFMPAMQFS VPPWQYDAEV
VAIAHKFAAL RASLVAPLLL ELAGEVTDTG DPIVRPLWWI APGDETAHRI DSQFLIGDTL
LVAPVLEPGK QERDVYLPAG KWRSYKGELF DKTPVLLTDY PVDLDEVAYF IWAS
//
