ID F6QT88_BOVIN Unreviewed; 450 AA.
AC F6QT88;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Growth differentiation factor 7 {ECO:0000313|Ensembl:ENSBTAP00000052102.2};
GN Name=GDF7 {ECO:0000313|Ensembl:ENSBTAP00000052102.2,
GN ECO:0000313|VGNC:VGNC:29305};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000052102.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000052102.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000052102.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000052102.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000052102.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; NP_001193030.1; NM_001206101.1.
DR AlphaFoldDB; F6QT88; -.
DR SMR; F6QT88; -.
DR STRING; 9913.ENSBTAP00000052102; -.
DR PaxDb; 9913-ENSBTAP00000052102; -.
DR Ensembl; ENSBTAT00000056229.3; ENSBTAP00000052102.2; ENSBTAG00000038224.3.
DR GeneID; 286859; -.
DR KEGG; bta:286859; -.
DR CTD; 151449; -.
DR VEuPathDB; HostDB:ENSBTAG00000038224; -.
DR VGNC; VGNC:29305; GDF7.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000160140; -.
DR HOGENOM; CLU_020515_2_0_1; -.
DR InParanoid; F6QT88; -.
DR OMA; RAPRAFC; -.
DR OrthoDB; 2912454at2759; -.
DR TreeFam; TF316134; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000038224; Expressed in endometrium and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0032924; P:activin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0048853; P:forebrain morphogenesis; IEA:Ensembl.
DR GO; GO:0022612; P:gland morphogenesis; IEA:Ensembl.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0060571; P:morphogenesis of an epithelial fold; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:2001051; P:positive regulation of tendon cell differentiation; IEA:Ensembl.
DR GO; GO:0048608; P:reproductive structure development; IEA:Ensembl.
DR GO; GO:0021509; P:roof plate formation; IEA:Ensembl.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl.
DR CDD; cd13766; TGF_beta_GDF5_6_7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF160; GROWTH_DIFFERENTIATION FACTOR 7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..450
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003340194"
FT DOMAIN 318..450
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 57..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 46769 MW; 255886C10ACB4D21 CRC64;
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPAESP GGGGGGSGTT LAAAEGTSAA
LAAASPGPRG ARRATGSGFR NGSVVPHQFM MSLYRSLTGR TPAGPVAVST SGSGRHGRAD
TVTGFADQAI PDESAAQTGL NFLFDVSSLP DADEVLGAEL RVLRRESGAR GPGSASPPLL
LLSTCPSAAS APRLLHSRAA EFLDAARWEV FDVADALRRH RREPRTSRAF CLSLSGVVGS
ARVPLALRPL GFGLRGGGGA AAEERALLVV SSRTQRKESL FREIRSQARA LGAALAVESR
PDSRPGVGSP TAVIGGRRRR RTALAGARAA QGSGGGAGRG HGRRGRSRCS RKPLHVDFKE
LGWDDWIIAP LDYEAYHCEG VCDFPLRSHL EPTNHAIIQT LLNSMAPDAA PASCCVPARL
SPISILYIDA ANNVVYKQYE DMVVEACGCR
//
