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Database: UniProt
Entry: F6QVC1_MONDO
LinkDB: F6QVC1_MONDO
Original site: F6QVC1_MONDO 
ID   F6QVC1_MONDO            Unreviewed;      2009 AA.
AC   F6QVC1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 48.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSMODP00000008632};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000008632, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000008632, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000008632}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000008632}.
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DR   STRING; 13616.ENSMODP00000008632; -.
DR   Ensembl; ENSMODT00000008802; ENSMODP00000008632; ENSMODG00000006587.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F6QVC1; -.
DR   OMA; RQKCPPW; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002280; Chromosome 4.
DR   Bgee; ENSMODG00000006587; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF235; PTHR10037:SF235; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    194    213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    397    424       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    756    783       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    795    818       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    830    854       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    875    903       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    965    988       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1213   1231       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1252   1268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1280   1300       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1344   1364       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1413   1434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1454   1477       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1544   1562       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1574   1592       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1604   1624       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1661   1689       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1765   1788       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      133    430       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      503    714       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      765    993       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1002   1207       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1211   1485       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1543   1798       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1802   1857       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      421    466       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2009 AA;  228946 MW;  ABDAD39FE1E379F8 CRC64;
     EKMATLPPPG PESFVFFTRQ SLELIEQRIS EGKSKEPKEE KTDEEEEGPK PSSDLEAGKQ
     LPFIYGDIPP GMVSEPLEDM DPYYMDKNTF IVLNKGKTIF RFSATPALYI LTPFNLIRRI
     SIKILALCKY LVVMLIMCTI LTNCIFMTLS SPPDWTKNVE YTFTGIYTFE SLVKILARGF
     CIGPFTFLRD PWNWLDFIVI CFAYVTEFVD LGNVSALRTF RVLRALKTIS VIPGLKTIVG
     ALIQSVKKLS DVMILTLFCL SVFALIGLQL FMGNLRHKCV RWPLEDKNIT IENIRNEILT
     SENKTLPISC LLSYTAQDLG YFYHLEGQKD ALLCGNSTDA GQCPEGYRCV KACTNPDYGY
     TSFDTFSWAF LALFRLMTQD FWENLYQQTL RAAGKTYMIF FVVVIFLGSF YLINLILAVV
     AMAYEEQNQA TIEEARQKEL EFQQMLDRLK KEQEEAEAII AAADEYTSIG GGKVMGLSES
     SSETSKLSSK SAKERRNRRK KKNQKKQSSG DEKRDNEKLS KSESDESIRK KSFHLGVEGH
     KLAREKRMSS PNQSPLSIRG SLLSARRSSR TSLFSFRGRG KDLGSETEFA DDEHSIFGDN
     ESRRGSLFVP HRHRERRSSN ISQASRSPRM LPVNGKMHSA VDCNGVVSLV DGPTALMLPN
     GQLLPEVIID KATSDDSGGT TKIDPNKRRS SSFQISMDML DDPTVRQRAL SIASIITNTM
     EELEESRQKC PPWWYKFANT FLIWNCSPRW LKFKKFIHLI VMDPFVDLAI TICIVLNTLF
     MAMEHYPMTE GFKNMLTVGN LVFTGIFAAE MVLKIIAMDP YEYFQVGWNI FDSVIVTLSL
     VELFLADVEG LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF
     AVVGMQLFGK SYKECVCKIS SDCELPRWHM NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG
     QSMCLIVYMM VMVIGNLVVL NLFLALLLSS FSSDNLTAIE EDTDANNLQI AVVRIKKGIN
     YIKKTIRELI QKAFVNKPKI SNEIRKVDDR NIKKENYISN RTLAEMSKDQ HFHIDRDGTS
     GFGSSMERYM MEESDCQSYI HNPSLTVTVP IAQGESDFEN VNTEEFSSES DVEGSKERVH
     RSSSSEGSTI DNAIPEDREE AVAEPENSDE PEACFTDGCV RRFPCCQVSV ESGNGKVWWN
     IRKTCYRIVE HNWFESFIVL MILLSSGALA FEDIYIEQRK TIKTVLEYAD KIFTYVFILE
     MLLKWVAYGY KVYFTNAWCW LDFLIVDVSI ITLVASTLGY SDLGPIKSLR TLRALRPLRA
     LSRFEGMRVV VNALLGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFYEC VNTTNGERFP
     VTVVETYEQC KQLMNSSHDV RWKNVKVNFD NVGIGYLSLL QVATFKGWMI IMYAAVDSVN
     INFQPKYEAS LYMYLYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKIIFI LFLYLGGQDI
     FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN KFQGCIFDIV TKQAFDITIM VLICLNMVTM
     MVEKDEQSET MTYVLYWINM VFIILFTGEC VLKLISLRHY YFTIGWNIFD FVVVILSIVG
     MFLADLIEKY FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF
     LVMFIYAIFG MSNFAYVKKE EGINDMFNFE TFGNSMICLF QITTSAGWDG LLAPILNSGP
     PDCDPEKVHP GSSVKGDCGN SSVGIFYFVS YIIISFLVVV NMYIAVILEN FSVATEESTE
     PLSEDDFEMF YEVWEKFDPD ATQFIEYSKL SDFAASLDPP LHIAKPNKVQ LVAMDLPMVN
     GDRIHCLDIL FAFTKRVLGE SEEMDTLRLQ MEERFVAANP SKVSFEPITT TLKRKQEEVS
     ATIIQRAFRH YRLRQNVKHI SGIYNKGGER VDLTMKEDMV FGKVNGNSTP EKTDEVTPST
     TSPPSYDSVT KRDKEKYEKD KAEKEDKDK
//
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