ID F6QYM2_HORSE Unreviewed; 1511 AA.
AC F6QYM2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=RUN and SH3 domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000022076.2};
GN Name=RUSC2 {ECO:0000313|Ensembl:ENSECAP00000022076.2,
GN ECO:0000313|VGNC:VGNC:22631};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022076.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022076.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022076.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022076.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022076.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F6QYM2; -.
DR STRING; 9796.ENSECAP00000022076; -.
DR PaxDb; 9796-ENSECAP00000022076; -.
DR Ensembl; ENSECAT00000026463.3; ENSECAP00000022076.2; ENSECAG00000024530.3.
DR VGNC; VGNC:22631; RUSC2.
DR GeneTree; ENSGT00900000141033; -.
DR HOGENOM; CLU_004141_0_0_1; -.
DR InParanoid; F6QYM2; -.
DR OMA; FDHEWKL; -.
DR OrthoDB; 3107370at2759; -.
DR TreeFam; TF332235; -.
DR Proteomes; UP000002281; Chromosome 25.
DR Bgee; ENSECAG00000024530; Expressed in prefrontal cortex and 23 other cell types or tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR CDD; cd17702; RUN_RUSC2; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047342; RUN_RUSC2.
DR InterPro; IPR047343; RUSC1_2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15591:SF14; AP-4 COMPLEX ACCESSORY SUBUNIT RUSC2; 1.
DR PANTHER; PTHR15591; RUN AND SH3 DOMAIN CONTAINING; 1.
DR Pfam; PF02759; RUN; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1028..1172
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1442..1501
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 41..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1207..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1248
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1349..1363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1511 AA; 161139 MW; 09C157DC3BCB2FDA CRC64;
MPLFELSRMD SPPKLTGETL IVHHIPLVHC QVPDRQCCGG ASGGSGSTRP NPFCPSELGI
TKPDQDLGQA DSLLYNSRHS STGGSARSAD STKSRGRDGR GPGAPKRHNP FLQQEGVAEP
GFGDLYEDSI GDSATQQQSF HLHGAGQPTF QLSSFQLPPT GPRVGRPWGT RRSRAGVVEG
QEQQPVTTLD TQECSTSYCC RPELEAETME LDECGGPGGS GSGGGASDTS GFSFDQEWKL
SSDESPRNPG CTGSGPQHCR CSSTSSQSET ADQSMGYVSD SSCNSSDGVL VTFSTLYNKM
HGNSHANLNS APQSCSDSSF CSHSDPGAFY LDLQTFPAEE SHHPNNGGRE GGYGCPHASS
PELDANCNSY HPHCEPCPAV ADLTACFQSQ ARLVVATQNY YKLVTCDLSS QSSPSPAGSS
ITSCSEEHTK ISPAPGPGPH PGPSQPSEYY LFQKPEVQPE EQEAGGSSEE AAAPVGPAMI
EGQVYTNTSP PNLSTGRQRS RSYDRSLERS PPVRLGSLER MLSCPVRLSE GPAALAGPSS
PPRRVTSFAE LAKGRKKAAG SGSPPLRVSI GDSSQDFSPI QETQQDRVGP LDKGTRCSHS
LPPMPLGPGM DLLDPEPWST QVCQGPQSSE MPSAGLRAAE QGPLAQLMDP GPALPGSPAN
SHPQRDARAR ADGGGAESRP VLRYSKEQRP TTLPIQPFVF QHHFPKQLAK ARALHSLSQL
YSLSGCSRAQ QPAPLAAPTA QVPAPAPSGE SQASANKGAG KAGPEPETSR PSPLGSYSPI
RSAGPFGPST DSSPSTSCSP PLEQATATES PPPWSHSCPP AVRPATSQQP PKEDQKILTL
AEYRLHGTGS LPPLGSWRSG FSRAESLARG GGEGSMASRP SNANHLSPQA LKWREYRRKN
PLGPPGLSGS LDRRPQEARL ARRNPIFEFP GSLSAAGHLN CRLNGQVVKP LPLTCPDFQD
PFSLTEKPPA EFCLSPDGNS EAISIDLLQK KGLVKAVNTA VDLIVAHFGT SRDPGVKAKL
GNSSVSPNVG HLVLKYLCPA VRAVLEDGLK AFVLDVIIGQ RKNMPWSVVE ASTQLGPSTK
VLHGLYNKVS QFPELTSHTM RFNAFILGLL NIRSLEFWFN HLYNHEDIIQ THYQPWGFLS
AAHTVCPGLF EELLLLLQPL ALLPFSLDLL FQHRLLQSGQ QQRQHKELLR VSQDLLLSAH
STLQLAQARG QEGPGDMDRA AHGERVKGVG APEGGEDEEE EEETEEMAEA AGGSGRGRWA
QGGQAGWWYQ LMQSSQVYID GSTEGSRFPR GGSNSSSGSS SEKKKGAGGR GPPPREGVVE
GAEACPAPEE TLGRAWPFWM GSPPDSVLAE LRRSREREGS TAPPAENEEG TSEPSPGGIK
WGHLFGSRKV QREARPTNRL PSDWLSLDKS MFQLVVQTVG ARREPEPRES LQEPHPPALP
SKPPCKVKAL CHHLATGPGQ LSFHKGDILR VLGPAKGDWL HCSRGTDMGL VPLAYVTLTP
TPSPTPGSSQ N
//
