ID F6QZJ8_XENTR Unreviewed; 329 AA.
AC F6QZJ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Mimecan {ECO:0000256|ARBA:ARBA00018423};
DE AltName: Full=Osteoglycin {ECO:0000256|ARBA:ARBA00031730};
GN Name=ogn {ECO:0000313|Ensembl:ENSXETP00000045198};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000045198};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000045198}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000045198};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000045198}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- FUNCTION: Induces bone formation in conjunction with TGF-beta-1 or TGF-
CC beta-2. {ECO:0000256|ARBA:ARBA00003759}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class III subfamily. {ECO:0000256|ARBA:ARBA00006912}.
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DR AlphaFoldDB; F6QZJ8; -.
DR STRING; 8364.ENSXETP00000045198; -.
DR Ensembl; ENSXETT00000045198; ENSXETP00000045198; ENSXETG00000027245.
DR AGR; Xenbase:XB-GENE-984781; -.
DR AGR; Xenbase:XB-GENE-999710; -.
DR Xenbase; XB-GENE-984781; ogn.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_067583_1_1_1; -.
DR InParanoid; F6QZJ8; -.
DR OrthoDB; 1080036at2759; -.
DR PhylomeDB; F6QZJ8; -.
DR TreeFam; TF351924; -.
DR Reactome; R-XTR-2022854; Keratan sulfate biosynthesis.
DR Reactome; R-XTR-2022857; Keratan sulfate degradation.
DR Bgee; ENSXETG00000027245; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043547; Mimecan/Epiphycan/Opticin.
DR PANTHER; PTHR46269; EPIPHYCAN-RELATED; 1.
DR PANTHER; PTHR46269:SF1; MIMECAN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 329 AA; 37132 MW; 4EE49684F5F83FAF CRC64;
MTRSSLTGIQ QGFHQENIFR SRAACNPGFA TRRLTMQPLP VCCTLLLLLP FILSAPSVPQ
QTISHHEDYI VEGKLFQLNL QKMAQTTERN GLTLLSKDRF KRDQERAGSN RTAAKVEDAD
LPTCLLCVCL SGSVYCEETE IEEVPPLPKE TAYLYARFNK IKKITAKDFS DFPTLRRIDL
TGNLIEEIDD KAFDKLPLLE QLNLAENKIT RIPALPTKLT VFNANDNQIK SKGIKANAFK
KLTSLAYLYL ANNQLESVPQ NLPESLRILH LQQNGISSIT DDTFCKSNDT HYVRSHMDEI
RMEGNPVILG KYPNSFTCLK TLPSGSYFK
//
