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Database: UniProt
Entry: F6R4T3_HORSE
LinkDB: F6R4T3_HORSE
Original site: F6R4T3_HORSE 
ID   F6R4T3_HORSE            Unreviewed;      2226 AA.
AC   F6R4T3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   31-JAN-2018, entry version 49.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSECAP00000010392};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010392, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000010392, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010392,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000010392}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010392};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000010392}.
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DR   STRING; 9796.ENSECAP00000010392; -.
DR   PaxDb; F6R4T3; -.
DR   Ensembl; ENSECAT00000013128; ENSECAP00000010392; ENSECAG00000011838.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; F6R4T3; -.
DR   OMA; DSPRNNA; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002281; Chromosome 25.
DR   Bgee; ENSECAG00000011838; -.
DR   ExpressionAtlas; F6R4T3; baseline.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     41     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     73     93       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    128    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    205    226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    238    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    390    410       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    416    433       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    454    472       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    515    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    593    615       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1040   1058       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1078   1098       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1110   1129       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1175   1197       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1287   1312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1368   1386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1398   1421       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1433   1457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1478   1507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1575   1598       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1614   1649       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      268    288       {ECO:0000256|SAM:Coils}.
FT   COILED      618    644       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2226 AA;  249170 MW;  6A9C078D2A67992B CRC64;
     PFEYMILATI IANCIVLALE QHLPDGDKTP MSERLDDTEP YFIGIFCFEA GIKILALGFV
     LHKGSYLRNG WNVMDFVVVL TGILATAGTD FDLRTLRAVR VLRPLKLVSG IPSLQVVLKS
     IMKAMVPLLQ IGLLLFFAIL MFAIIGLEFY MGKFHKACFS NSTDADPVGD FPCGKEAPAR
     LCEGDTECRE YWPGPNFGIT NFDNILFAIL TVFQCITMEG WTDILYNTND AAGNTWNWLY
     FIPLIIIGSF FMLNLVLGVL SGEFAKERER VENRRAFLKL RRQQQIEREL NGYLEWIFKA
     EEVMLAEEDK NAEEKSPLDA VLKRAATKKS RNDLIHAEEG EDRFADLCAV GSPFARASLK
     SGKTESSSYF RRKEKMFRFF IRRMVKAQSF YWVVLCVVAL NTVCVAMVHY NQPQRLTTAL
     YFAEFVFLGL FLTEMSLKMY GLGPRSYFRS SFNCFDFGVI VGSIFEVVWA AIKPGTSFGI
     SVLRALRLLR IFKVTKYWNS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ
     FNFEDETPTT NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVSKGMF SSFYFIVLTL
     FGNYTLLNVF LAIAVDNLAN AQELTKDEEE MEEAANQKLA LQKAKEVAEV SPMSAANISI
     AAKGEGGAKA SPAWGSCSSS PRLVNAGTHT HSRSHVHSHT RSCSFSHIHT HPDTHSHIWR
     PVGAKSGGGG LFGIVGQVGQ LQASLLQPGG DVPSLVERHR VRDQRGPNCS VARTEQPRGQ
     GQAESSTKEE RLVHRMRPSR EEASGATNAG CSVVRRRHRR GSPEEAAERE PRRHRAHRLA
     PDQGKEGERR ARHRGPRAGP REAESGEEPA RRHRARHKAL PAHEDAEKEA AERESGVEDR
     DKDKELRNHQ PREPHCDLEA TGIMGVGPVH ALPSTCLQKV EEQPEDADNQ RNVTRMGSQP
     SDPSTTVPIP VMLTGPPGET TVVPSGNVDL ESQAEGKKEV EADDVMRSGP RPIVPYSSMF
     CLSPTNLLRR FCHYIVTMRY FEMVILVVIA LSSIALAAED PVRTDSPRNN ALKYMDYIFT
     GVFTFEMVMK MIDLGLLLHP GAYFRDLWNI LDFIVVSGAL VAFAFSSFMG GSKGKDINTI
     KSLRVLRVLR PLKTIKRLPK LKAVFDCVVN SLKNVLNILI VYMLFMFIFA VIAVQLFKGK
     FFYCTDESKE LERDCRGQYL DYEKEEVEAQ PRQWKKYDFH YDNVLWALLT LFTVPREEGG
     PWVLKHSVDA TYEEQGPSPG YRMELSIFYV VYFVVFPFFF VNIFVALIII TFQEQGDKVM
     SECSLEKNER ACIDFAISAK PLTRYMPQNK QSFQYKTWTF VVSPPFEYFI MAMIALNTVV
     LMMKFYDAPY EYELMLKCLN IVFTSMFSME CVLKIIAFGV LNYFRDAWNV FDFVTVLGSI
     TDILVTEIAN NFINLSFLRL FRAARLIKLL RQGYTIRILL WTFVQSFKAL PYVCLLIAML
     FFIYAIIGMQ VFGNIALDDD TSINRHNNFR TFLQALMLLF RSATEEAWHE IMLSCLNQAC
     DEHANASECG SDFAYFYFVS FIFLCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI
     RVWAEYDPAA CGRISYSDMF EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH
     FTSTLMALIR TALEIKLAPA GTKQHQCDAE LRKEISSVWA NLPQKTLDLL VPPHKPDEMT
     VGKVYAALMI FDFYKQNKTT RDQIHQAPGG LSQMGPVSLF HPLKATLEQT QPAVLRGARV
     FLRQKSSASL SNGGAVQTQE SGIKESVSWG TQRTQEGPYE ARTPLERGHS AEIPVVQPGK
     SAVDVQMQSM ALRGPDGEPQ PGLESQGRAA SMPRLAAETQ PAPDASPMKR SISTLAPQRS
     HVAHLCTAAL DRAPASQAPH HHHRCHRRRD RKQKSLEKGP SLSADTDGAP SSTAGPGPPL
     AEGPAGCRRE RRQERGRSQE RRQPSSSSSE KQRFYSCDRF GGREPPQPKP ALGSHPTSPT
     AGQEPGPPRQ GGGSVNGSPL LSTSGASTPG RGGRRKLPQT PLTPRPSITY KTANSSPVHF
     TGAQTSLPAF SPGRLSRGLS EHNALLQRDP LSQPLAPGSR IGSDPYLGQR LDSEAAARTQ
     PEDTLTFEEA VATNSGRSSR TSYVSSLTSQ SHPLRRVPNG YHCTLGLSSG SRARHSYHHP
     DQDHWC
//
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