ID F6R535_ORNAN Unreviewed; 760 AA.
AC F6R535;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Rabenosyn, RAB effector {ECO:0000313|Ensembl:ENSOANP00000022112.1};
GN Name=RBSN {ECO:0000313|Ensembl:ENSOANP00000022112.1};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000022112.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000022112.1, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022112.1,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000022112.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022112.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001506047.1; XM_001505997.3.
DR RefSeq; XP_007653571.1; XM_007655381.2.
DR RefSeq; XP_007653572.1; XM_007655382.2.
DR AlphaFoldDB; F6R535; -.
DR STRING; 9258.ENSOANP00000022112; -.
DR Ensembl; ENSOANT00000022116.3; ENSOANP00000022112.1; ENSOANG00000014024.3.
DR GeneID; 100074432; -.
DR KEGG; oaa:100074432; -.
DR CTD; 64145; -.
DR eggNOG; KOG1842; Eukaryota.
DR GeneTree; ENSGT00390000007159; -.
DR HOGENOM; CLU_020798_2_0_1; -.
DR InParanoid; F6R535; -.
DR OMA; CEHCLWL; -.
DR OrthoDB; 1441111at2759; -.
DR TreeFam; TF106125; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000014024; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034498; P:early endosome to Golgi transport; IEA:Ensembl.
DR GO; GO:0090160; P:Golgi to lysosome transport; IEA:Ensembl.
DR GO; GO:1903358; P:regulation of Golgi organization; IEA:Ensembl.
DR CDD; cd15716; FYVE_RBNS5; 1.
DR Gene3D; 4.10.860.20; Rabenosyn, Rab binding domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR021565; Rbsn_Rab-bd.
DR InterPro; IPR036531; Rbsn_Rab-bd_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13510; FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED; 1.
DR PANTHER; PTHR13510:SF44; RABENOSYN-5; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF16601; NPF; 1.
DR Pfam; PF11464; Rbsn; 2.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF140125; Rabenosyn-5 Rab-binding domain-like; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 157..260
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 207..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 474..508
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 578..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 86789 MW; 88BCE2379668F7CB CRC64;
MASIDDPGEV REGFLCPLCL KDLQSFYQLH SHYEEEHSTE DRDVKGQIKS LVQKAKKAKN
KLLKRDGDDR TESGTQGYES FSYGGVDPYM WEPQELGAVR SHLSDFKKHR AARIDHYVVE
VNKLIIRLEK LTAFDRTNTE AAKIRAIEKS VVPWVSDQDV PFCPDCGNKF SIRNRRHHCR
LCGSIMCKRC MDLIGLPLAS KLTSASKEAL TSHTSPNQSP NSVHGSRRGS ISSVSSVSSV
LDEKDDDRIR CCGHCKETLL KREHQIDEKE YIPDIVKFYE KLRYYMETVE QKAPEYIRMA
ASLNAGETSY SLEHANNLRV EVQKVYELID ALSKKILTLG LNQNPQPHPK ALQLQRMIRY
SATLFVQEKL LGLMSLPTQK QYEELKEKRK QDMEKRMQME RQGALDSQRR ADERQKDLAI
RAMANGEEVQ TGGNILRKSE GWLPTSSGPR QSEISDPLLQ QIDNITSFIK QAKAASRLDE
VRMLQENLRQ LQDEYDQQQT EKAIELSKRQ AEEEDMQREQ LQVLREKEWE RERQQAEFQP
SQTCSEAREI KPFQLETGKD RWNQLEPALD LDAPQLPSPS AIQESIFEAP QQSTRLQQNE
VAAWNPFEEQ EASKGGEKDP FNPFAEDLSP GASSPGPVLP GRKKEYNPFE DEDEEAANNG
IDSASNPFEE GERLPRKPPG PSGPSNPFEK LASTNPFDVD DENGVETELI EEDLLLQQID
NIKAYIFDAK HSGRLDEVEV LTENLKELKR TLAKQKEKDN
//
