ID F6RFR8_ORNAN Unreviewed; 1403 AA.
AC F6RFR8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=BMS1 ribosome biogenesis factor {ECO:0000313|Ensembl:ENSOANP00000001035.2};
GN Name=BMS1 {ECO:0000313|Ensembl:ENSOANP00000001035.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000001035.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000001035.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000001035.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000001035.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000001035.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR STRING; 9258.ENSOANP00000001035; -.
DR Ensembl; ENSOANT00000001036.3; ENSOANP00000001035.2; ENSOANG00000000662.4.
DR eggNOG; KOG1951; Eukaryota.
DR GeneTree; ENSGT00940000153195; -.
DR HOGENOM; CLU_002486_0_1_1; -.
DR InParanoid; F6RFR8; -.
DR OMA; KLHVPMV; -.
DR TreeFam; TF105751; -.
DR Proteomes; UP000002279; Chromosome 3.
DR Bgee; ENSOANG00000000662; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR CDD; cd01882; BMS1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR037875; Bms1_N.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12858; RIBOSOME BIOGENESIS PROTEIN; 1.
DR PANTHER; PTHR12858:SF2; RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 188..353
FT /note="Bms1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51714"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..561
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..588
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..642
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..726
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..935
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1386..1403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 159727 MW; 82E0EBC3135D35C3 CRC64;
MNEKGGGRRE GEEEEREGGR KRRRVERRGE GGREGGEGRR TGEKGRKRKR EKQRKKRREG
GREEGTGRRE KNNHVGICWE VGFHQAVPPE ARRLHPHFTG DPWKPSADME DQDKKKHRKK
QSGPKADKKK KRHLKDLGLG DEEDARKRNP RAFAVQSAVR MARAFHRTQD LKTKKHHIPV
VDRTPLEPPP VVVVVMGPPK VGKSTLIHCL IRNFTRQKLT DIRGPVTIVS GKKRRLTIIE
CGCDINVMID LAKVADLVLM LIDASFGFEM ETFEFLNICQ VHGFPKIMGV LTHLDTFKNN
KQLKKTKKRL KHRFWTEVYP GAKLFYLSGM VHGEYQNQEI HNLGRFITVM KFRPLTWQTS
HPYILADRME DLTNPEDIRL NSKCDRKVSV YGYLRGAHLK NKSQIHMPGV GDFTVSDVSF
LPDPCALPEQ QKKRCLNEKE KLVYAPLSGV GGVLYDKDAV YVDLGGSHAF QDEEEEVGPT
QELVQSLISA HSTIDAKMAS SKVSLFTDSK PLGSEEVERQ GFILPKEERR LDPVTGRVRR
KAVFEGEEED DDDDGDEEML EEDGMKNGAS DDGTDEEEEE EEDDDDDENG HRAPEKERAP
RSVKRVKLEV KEEIQMDLPA FADSDDDLER SSGEEEADEG GEEVKESAGG DESDESSESE
AVKQSGGKYK QGAGLSPGLR LKKPSPGEKA TLAVTDSGHC TAEEAFASDT DSEEGSSLES
EEEASGDEEP AGKGIPKSQR GKAVSGEHLD SENLGEENTE VEDLLKEEGE YREEIDFSAE
TAGALRWKED LTRKAAEAFL RQQQATPNLR KLIYGTVAED DEDDEEEAKE ELGGLFHVSR
PDKESKRKAD GLDCSKFPVE APQDWDLEEV MNNIRDCFVT GKWEADKDAA KLLEKDEELY
GDFEDLETGH VQKGKSSSQE DEVESEEEEI KEEKECKEEE DAKKKRMDKK RKLKEMFDAE
YDEGETTYFD DLKDEMQKQA QLNRAEFEDQ DDEARVQYEG YRPGMYVRIE IENIPCEFVL
NFDPHYPIIL GGLGNSEGNV GFVHMRLKKH RWYKKILKSR DPLIFSLGWR RFQTIPLYYI
EDHNGRQRLL KYTPQHMHCG ATFWGPITPQ GTGFLAVQSV SGTMSDFRIA ATGVVLDLDK
SITIVKKLKL TGFPYKIYKN TSFVKGMFNS ALEVAKFEGA AIRTVSGVRG QIKKALRTPE
GAFRATFEDK LLMSDIVFMR TWYPVSVPAF YNPVTSLLKP VGEKNSWTGM RTTGQLRHDQ
GIRLKQNKDS VYKPIVRQKR HFNSLHIPKA LQKALPFKSK PKFQEKKGKV SRDRVRPAVI
REPHERKIAA LLSALGTVHS YKVRKAKQKQ QQQHKEHLKV KQKEDEEKLQ RQKEARKKLF
RIRGQREKKN QKSSLKGSGE QEK
//
