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Database: UniProt
Entry: F6RJ92_HORSE
LinkDB: F6RJ92_HORSE
Original site: F6RJ92_HORSE 
ID   F6RJ92_HORSE            Unreviewed;      1881 AA.
AC   F6RJ92;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 41.
DE   SubName: Full=Calcium voltage-gated channel subunit alpha1 D {ECO:0000313|Ensembl:ENSECAP00000015408};
GN   Name=CACNA1D {ECO:0000313|Ensembl:ENSECAP00000015408};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015408, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000015408, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015408,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000015408}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015408};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000015408}.
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DR   PaxDb; F6RJ92; -.
DR   Ensembl; ENSECAT00000018862; ENSECAP00000015408; ENSECAG00000015892.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000002281; Chromosome 16.
DR   Bgee; ENSECAG00000015892; -.
DR   ExpressionAtlas; F6RJ92; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF239; PTHR10037:SF239; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     87    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    247    265       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    285    308       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    449    476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    611    629       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    649    669       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    681    707       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    727    757       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    854    879       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    933    951       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    963    983       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1073   1091       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1165   1188       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1322   1356       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      479    510       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1881 AA;  214182 MW;  9FE5E8896AFD061F CRC64;
     MHKTCFFADS DVVAEEDPAP CAFSGNGRQC TANGTECRSG WVGPNGGITN FDNFAFAMLT
     VFQCITMEGW TDVLYWMNDA MGFELPWVYF VSLVIFGSFF VLNLVLGVLS GEFSKEREKA
     KARGDFQKLR EKQQLEEDLK GYLDWITQAE DIDPENEEEG GEESKRNTSM PTSETESVNT
     ENVSGEGESQ GCCGSLWCWW RRRGAAKAGP SGCRRWGQAI SKSKLSRRWR RWNRFNRRRC
     RAAVKSVTFY WLVIVLVFLN TLTISSEHYN QPDWLTQIQD IANKVLLALF TCEMLVKMYS
     LGLQAYFVSL FNRFDCFVVC GGITETILVE LEIMSPLGIS VFRCVRLLRI FKVTRHWTSL
     SNLVASLLNS MKSIASLLLL LFLFIIIFSL LGMQLFGGKF NFDETQTKRS TFDNFPQALL
     TVFQILTGED WNAVMYDGIM AYGGPSSSGM IVCIYFIILF ICGNYILLNV FLAIAVDNLA
     DAESLNTAQK EEAEEKERKK IARKESLENK KTNKPEVNQI ANSDNKVTID DYREEDEDKD
     PYPPCDVPVG EEEEEEEEDE PEVPAGPRPR RISELNMKEK IAPIPEGSAF FILSKTNPIR
     VGCHKLINHH IFTNLILVFI MLSSAALAAE DPIRSHSFRN TILGYFDYAF TAIFTVEILL
     KMTTFGAFLH KGAFCRNYFN LLDMLVVGVS LVSFGIQSSA ISVVKILRVL RVLRPLRAIN
     RAKGLKHVVQ CVFVAIRTIG NIMIVTTLLQ FMFACIGVQL FKGKFYRCTD EAKSNPEECR
     GLFILYKDGD VDNPVVRERI WQNSDFNFDN VLSAMMALFT VSTFEGWPAL LYKAIDSNGE
     NVGPIYNYRV EISIFFIIYI IIVAFFMMNI FVGFVIVTFQ EQGEKEYKNC ELDKNQRQCV
     EYALKARPLR RYIPKNPYQY KFWYVVNSSP FEYMMFVLIM LNTLCLAMQH YEQSKMFNDA
     MDILNMVFTG VFTVEMVLKV IAFKPKHYFT DAWNTFDALI VVGSVVDIAI TEVNPTESEN
     VPVPTATPGN SEESNRISIT FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL
     IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV LLLFRCATGE AWQEIMLACL
     PGKLCDPESD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII NLFVAVIMDN FDYLTRDWSI
     LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL GFGKLCPHRV ACKRLVAMNM
     PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV IKKIWKKTSM KLLDQVVPPA
     GDDEVTVGKF YATFLIQDYF RKFKKRKEQG LVGKYPAKNT TIALQAGLRT LHDIGPEIRR
     AISCDLQDDE PEETKREEEE DVFKVIIPRL ATHWPPGNIN DPQKSLENAN EPQPRGACGP
     SLPPADPSPW PQLLAGVDDH PGQPSIPQLP SPGSMPTPNL NLSLNGAANR PCWALRNLVH
     CLNGHHSSHK HDREPQRRSS IKRTRYYETY IRSDSGDEQF PTICREDPEI HGYFRDARCW
     GEQEYFSGEE CYEDDSSPTW SRQNYSYYNR YPGSNLDFER PRGYHHPQSF LEDDDSPVCY
     DSRRSPRRRL LPPTPTSHRR SSFNFECLRR QSSQEEVSPS PAFPHRTALP LHLMQQQIMA
     VAGLDSSKAQ KYSPSHSTRS WATPPATPPY RDWTPCYTPL IQVERPEALD QVNGSLPSLH
     RSSWYTDEPG ISYRTFTPAS LTVPSSFRNK NSDKQRSADS LVEAVLISEG LGRYARDPKF
     VSATKHEIAD ACDLTIDEME SAASNLLNGN MHPRANGDVG PGSHRQDFEL QDFGPGYSDE
     EPDPGRDEED LADEMICITT L
//
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