ID F6RJH8_MACMU Unreviewed; 2066 AA.
AC F6RJH8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 81.
DE SubName: Full=Myosin XVIIIA {ECO:0000313|Ensembl:ENSMMUP00000013005.4};
GN Name=MYO18A {ECO:0000313|Ensembl:ENSMMUP00000013005.4,
GN ECO:0000313|VGNC:VGNC:75058};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000013005.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Ensembl:ENSMMUP00000013005.4, ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000013005.4,
RC ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000013005.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000013005.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR PaxDb; 9544-ENSMMUP00000013005; -.
DR Ensembl; ENSMMUT00000013881.4; ENSMMUP00000013005.4; ENSMMUG00000009938.4.
DR VEuPathDB; HostDB:ENSMMUG00000009938; -.
DR VGNC; VGNC:75058; MYO18A.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000155768; -.
DR HOGENOM; CLU_000192_1_0_1; -.
DR TreeFam; TF339614; -.
DR Proteomes; UP000006718; Chromosome 16.
DR Bgee; ENSMMUG00000009938; Expressed in hindlimb stylopod muscle and 20 other cell types or tissues.
DR ExpressionAtlas; F6RJH8; baseline.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IEA:InterPro.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006259; P:DNA metabolic process; IEA:InterPro.
DR CDD; cd01386; MYSc_Myo18; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF13; UNCONVENTIONAL MYOSIN-XVIIIA; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50163; RECA_3; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 220..311
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 361..413
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 417..1197
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 554..619
FT /note="RecA family profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50163"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1864..1913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1974..2066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1261..1365
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 140..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1974..1997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2011..2026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2044..2058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 510..517
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2066 AA; 234563 MW; 39DB40B4E472EC22 CRC64;
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL
EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR
AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP
GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPALRE LELQRRPTGD FGFSLRRTTM
LDRGPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVENKSRD EIVEMIRQSG
DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDLDSEAAS RAHSQAKTEE QIAAEEAWNE
TEKVWLVHRD GFSLASQLKS EELSLPEGKV RVKLDHDGAI LDVDEDDVEK ANAPSCDRLE
DLASLVYLNE SSVLHTLRQR YGASLLHTYA GPSLLVLGPR GAPAVYSEKV MHMFKGCRRE
DMAPHIYAVA QTAYRAMLMS RQDQSIILLG SSGSGKTTSC QHLVQYLATI AGISGNKVFS
VEKWQALYTL LEAFGNSPTI MNGNATRFSQ ILSLDFDQAG QVASASIQTM LLEKLRVARR
PASEATFNIF YYLLACGDGT LRTELHLNHL AENNVFGIVP LAKPEEKQKA AQQFSKLQAA
MKVLGISPDE QKACWLILAA IYHLGAAGAT KEAAEAGRKQ FARHEWAQKA AYLLGCSLEE
LSSAIFKHQH KGGTLQRSTS FRQGPEESGL GDGTGPKLSA LECLEGMAAG LYSELFTLLV
SLVNRALKSS QHSLCSMMIV DTPGFQNPEQ GGSARGASFE ELCHNYTQDR LQRLFHERTF
VQELERYKEE NIELAFDDLE SPTDDSVAAV DQASHQSLVR SLARTDEARG LLWLLEEEAL
VPGASEDTLL ERLFSYYGPQ EGDKKGQSPL LRSSKPHHFL LGHSHGTNWV EYNVTGWLNY
TKQNPATQNA PRLLQDSQKK IISNLFLGRA GSATVLSGSI AGLEGGSQLA LRRATSMRKT
FTTGMAAVKK KSLCIQMKLQ VDALIDTIKK SKLHFVHCFL PVAEGWAGEP RSASSRRVSS
SSELDLPSGD HCEAGLLQLD VPLLRTQLRG SRLLDAMRMY RQGYPDHMVF SEFRRRFDVL
APHLTKKHGR NYIVVDERRA VEELLECLDL EKSSCCMGLS RVFFRAGTLA RLEEQRDEQT
SRNLTLFQAA CRGYLARQHF KKRKIQDLAI RCVQKNIKKN KGVKDWPWWK LFTTVRPLIE
VQLSEEQIRN KDEEIQQLRS KLEKVEKERN ELRLNSDRLE SRISELTSEL TDERNTGESA
SQLLDAETAE RLRAEKEMKE LQTQYDALKK QMEVMEMEVM EARLIRAAEI NGEVDDDDAG
GEWRLKYERA VREVDFTKKR LQQEFEDKLE VEQQNKRQLE RRLGDLQADS EESQRALQQL
KKKCQRLTAE LQDTKLHLEG QQVRNHELEK KQRRFDSELS QAHEEAQREK LQREKLQREK
DMLLAEAFSL KQQLEEKDMD IAGFTQKVVS LEAELQDISS QESKDEASLA KVKKQLRDLE
AKVKDQEEEL DEQAGTIQML EQAKLRLEME MERMRQTHSK EMESRDEEVE EARQSCQKKL
KQMEVQLEEE YEDKQKVLRE KRELEGKLAT LSDQVNRRDF ESEKRLRKDL KRTKALLADA
QLMLDHLKNS APSKREIAQL KNQLEESEFT CAAAVKARKA MEVEIEDLHL QIDDIAKAKT
VLEEQLSRLQ REKNEIQNRL EEDQEDMNEL MKKHKAAVAQ ASRDLAQIND LQAQLEEANK
EKQELQEKLQ ALQSQVEFLE QSMVDKSLVS RQEAKIRELE TRLEFERTQV KRLESLASRL
KENMEKLTEE RDQRIAAENR EKEQNKRLQR QLRDTKEEMG ELARKEAEAS RKKHELEMDL
ESLEAANQSL QADLKLAFKR IGDLQAAIED EMESDENEDL INSLQDMVTK YQKRKNKLEG
DSDVDSELED RVDGVKSWLS KNKGPSKAAS DDGSLKSSSP TSYWKSLAPD RSDDEHDPLD
NTSRPRYSHS YLSDSDTEAK LMETNK
//