ID F6RJJ1_XENTR Unreviewed; 824 AA.
AC F6RJJ1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Cullin 4B {ECO:0000313|Ensembl:ENSXETP00000004168};
GN Name=cul4b {ECO:0000313|Ensembl:ENSXETP00000004168};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000004168};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000004168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000004168};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000004168}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR AlphaFoldDB; F6RJJ1; -.
DR Ensembl; ENSXETT00000004168; ENSXETP00000004168; ENSXETG00000004474.
DR AGR; Xenbase:XB-GENE-963628; -.
DR Xenbase; XB-GENE-963628; cul4b.
DR UniPathway; UPA00143; -.
DR Bgee; ENSXETG00000004474; Expressed in egg cell and 14 other cell types or tissues.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF66; CULLIN-4B; 1.
DR Pfam; PF00888; Cullin; 2.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 2.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 543..649
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT DOMAIN 651..697
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 824 AA; 94677 MW; F21423D54081D76E CRC64;
MRPARSGIMK DLIASPSGQS KQGLSTPNPP AQEVRTEGNS TSKKRRLNIS SSDKDDLDPL
SPPRNSSSSS NHIQKKLRFE DTLDFLGLDV KMAEESPSSS CSSSSTPQAV RSKNLLISPV
GVGHHANGLT KASPVSSFAN SKPGSAKKLV IKNFKDKPKL PENYTDETWQ KLKGAVEAIQ
NSTSIKYNLE ELYQAVENLC SYKISANLYK QLRQICEDHI KAQIHQFRED ALDSVLFLKK
IDKCWQDHCR QMKDSLSGKP LVLGILDNRS HTCIGTGSKR KCFLQIMIRS IFLFLDRTYV
LQNSMLPSIW DMGLELFRNH IISDQKVQNK TIDGILLLIE RERNGEAIDR SLLRSLLSML
SDLQIYQDSF EQRFLEETNR LYAAEGQRLM QEREVPEYLH HVNKRLEEEA DRVITYLDQS
TQKPLIATVE KQLLGEHLTA TLQKGLNHLL DENRIQDLSL LYQLFSRVRG GVQVLLQHWI
EYIKAFGSTI VINPEKDKTM VQELLDFKDK VDHVIDVCFL KNEKFVNAMK EAFETFINKR
PNKPAELIAK YVDSKLRTGN KEATDEELEK MLDKIMIIFR FIYGKDVFEA FYKKDLAKRL
LVGKSASVDA EKSMLSKLKH ECGAAFTSKL EGMFKDMELS KDIMVHFKQG KKELQVSLFQ
TLVLLMFNEG DEFSLEEIRQ ATGIEDSELR RTLQSLACGR ARVLVKSPKS KDVDDGDKFT
FNDDFRHQLF RIRINQIQMK ETVEEQASTT ERVFQDRQYQ IDAAIVRIMK MRKTLSHNLL
VSEVYNQLKF PVKPADLKKR IESLIDRDYM ERDKENPNQY NYVA
//
