ID F6RM04_BOVIN Unreviewed; 894 AA.
AC F6RM04;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=RNA binding motif protein 15B {ECO:0000313|Ensembl:ENSBTAP00000008515.6};
GN Name=RBM15B {ECO:0000313|Ensembl:ENSBTAP00000008515.6,
GN ECO:0000313|VGNC:VGNC:111297};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000008515.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000008515.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008515.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000008515.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008515.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RRM Spen family.
CC {ECO:0000256|ARBA:ARBA00005387}.
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DR RefSeq; NP_001193510.1; NM_001206581.1.
DR AlphaFoldDB; F6RM04; -.
DR SMR; F6RM04; -.
DR STRING; 9913.ENSBTAP00000008515; -.
DR PaxDb; 9913-ENSBTAP00000008515; -.
DR Ensembl; ENSBTAT00000008515.6; ENSBTAP00000008515.6; ENSBTAG00000006500.6.
DR GeneID; 508868; -.
DR KEGG; bta:508868; -.
DR CTD; 29890; -.
DR VEuPathDB; HostDB:ENSBTAG00000006500; -.
DR VGNC; VGNC:111297; RBM15B.
DR eggNOG; KOG0112; Eukaryota.
DR GeneTree; ENSGT00940000160561; -.
DR HOGENOM; CLU_012724_1_0_1; -.
DR InParanoid; F6RM04; -.
DR OMA; PGSCEYK; -.
DR OrthoDB; 2873387at2759; -.
DR TreeFam; TF354224; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000006500; Expressed in vas deferens and 105 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12554; RRM1_RBM15B; 1.
DR CDD; cd12556; RRM2_RBM15B; 1.
DR CDD; cd12558; RRM3_RBM15B; 1.
DR CDD; cd21550; SPOC_RBM15B; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034475; RBM15B_RRM1.
DR InterPro; IPR034535; RBM15B_RRM2.
DR InterPro; IPR034536; RBM15B_RRM3.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR010912; SPOC_met.
DR PANTHER; PTHR23189; RNA RECOGNITION MOTIF-CONTAINING; 1.
DR PANTHER; PTHR23189:SF40; RNA-BINDING PROTEIN 15B-RELATED; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF07744; SPOC; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR PROSITE; PS50102; RRM; 3.
DR PROSITE; PS50917; SPOC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 139..215
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 341..418
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 422..496
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 715..893
FT /note="SPOC"
FT /evidence="ECO:0000259|PROSITE:PS50917"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..127
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 97281 MW; 29F6DAAFAFFDCF65 CRC64;
MKRQSERDSS PSGRGSSSSA KRPREREREA EAGGRRAAHK ASGGAKHPVP TRARDKPRGS
GGSGGGHRDG RGAGDANHRA SSGRSSGSGA GGGGRGGKAS GDPGASGASP RASPLPPPPP
PPGAEPTGPG SSAAAPEYKT LLISSLSPAL PAEHLEDRLF HQFKRFGEIS LRLSHTPELG
RVAYVNFRHP QDAREARQHA LARQLLLYDR PLKVEPVYLR GGGGGGGSSR RSSSSSAAAS
TPPPGPPAPA DPLGYLPLHG GYQYKQRSLS PVAAPPLREP RARHAAAAFA LDAAAAAAAV
GLSRERALDY YGLYDDRGRP YGYPAVCEED LMPEDDQRAT RNLFIGNLDH SVSEVELRRA
FEKYGIIEEV VIKRPARGQG GAYAFLKFQN LDMAHRAKVG MSGRVIGRNP IKIGYGKANP
TTRLWVGGLG PNTSLAALAR EFDRFGSIRT IDHVKGDSFA YIQYESLDAA QAACAKMRGF
PLGGPDRRLR VDFAKAEETR YPQQYQPSPL PVHYELLPDG YTRHRNLDAD LRVRDRTPPH
LLYSDRERTF LEGDWTSPSK SSDRRNSLEG YSRSVRSRSG ERWGGDGDRG LPKAWEDRRK
RRSLSSDRGR ATHSPYEERS RTKGGGQPAD RGSDRTPERS RKENHSSEGT KESGSNSLSN
SRHGAEERSH HHHHEAPDSS HGKKTRESER NHRTTEAEPK PLEEPKHETK KLKNLSEYAQ
TLQLGWNGLL VLKNSCFPTS MHILEGDQGV ISSLLKDHTS GSKLTQLKIA QRLRLDQPKL
DEVTRRIKQG SPNGYAVLLA TQATPSGPGS EGMPTVEPGL QRRLLRNLVS YLKQKQAAGV
ISLPVGGSKG RDSTGMLYAF PPCDFSQQYL QSALRTLGKL EEEHMVIVIV RDTA
//
