ID F6RM15_HORSE Unreviewed; 648 AA.
AC F6RM15;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Rho GTPase activating protein 18 {ECO:0000313|Ensembl:ENSECAP00000022313.3};
GN Name=ARHGAP18 {ECO:0000313|Ensembl:ENSECAP00000022313.3,
GN ECO:0000313|VGNC:VGNC:15461};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022313.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022313.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022313.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022313.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022313.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6RM15; -.
DR Ensembl; ENSECAT00000026714.3; ENSECAP00000022313.3; ENSECAG00000024764.3.
DR CTD; 93663; -.
DR VGNC; VGNC:15461; ARHGAP18.
DR GeneTree; ENSGT00940000157142; -.
DR HOGENOM; CLU_023268_2_1_1; -.
DR OrthoDB; 11483at2759; -.
DR TreeFam; TF314044; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000024764; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR ExpressionAtlas; F6RM15; baseline.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF6; RHO GTPASE-ACTIVATING PROTEIN 18; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 309..508
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 73390 MW; 0F692CEAE20FD388 CRC64;
MSSVHHTSVS ESRDRQGDGQ RSRRCGQYTM NQQITKVTEK PPFDRSSSQD SMDEVSMEDY
WTELENIKKS NENRQEDQEV VVVKEPDEGE LEEEWLKEAG LSNLFGEAAG DPQESMVFLS
TLTRTQAAAV QKRVETVSQT LRKKNKQYQI PDVRDIFAQQ RESNDKVPDG TESQSVRTNE
NKYRGKDDRA SSLVVGEKEL ILLVPEEAPA SETDINLEVS FAEQAVSQKE SSKEKIQKNR
GDDGPLPNFR LPKDKTGTTR IGDLACQDMK KVCYLALIEL TALYDVLGVE LKQQKAVKIK
TKDSGLFGVP LTVLLEQDQR KVSGTRIPLI FQKLISRIEE GGLETEGLLR IPGAATRIKN
LCQELEAKFY EGTFNWESVK QHDAASLLKL FIRELPQPLL SVEYLKAFQA VQNLPAKKQQ
LQALNLLVIL LPDANRDTLK ALLEFLQRVI DSKEKNKMTA MNVAMVMAPN LFMCHTLGLK
SSEQQEFVMA AGTANIMHLL IKYQKLLWTI PKFIVNQVRK QNTENHKKDK KAMKKLLKKM
AYDREKYEKQ DKTANDADVP QGVIRVQAPH LSKVSMAIQL TEELKASDVL ARFLSQESGI
VQTLKKGEVF LYEVGGNIGE RCLDDDTHMK DLYQLNPNAE WVIKSKPS
//
