ID F6RSW4_ORNAN Unreviewed; 625 AA.
AC F6RSW4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=DEF6 guanine nucleotide exchange factor {ECO:0000313|Ensembl:ENSOANP00000024044.3};
GN Name=DEF6 {ECO:0000313|Ensembl:ENSOANP00000024044.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024044.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000024044.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024044.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000024044.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024044.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6RSW4; -.
DR STRING; 9258.ENSOANP00000024044; -.
DR Ensembl; ENSOANT00000024048.3; ENSOANP00000024044.3; ENSOANG00000015275.3.
DR eggNOG; ENOG502QUWV; Eukaryota.
DR GeneTree; ENSGT00950000183017; -.
DR HOGENOM; CLU_029358_0_0_1; -.
DR InParanoid; F6RSW4; -.
DR OMA; EHRCIEL; -.
DR OrthoDB; 5354765at2759; -.
DR TreeFam; TF333160; -.
DR Proteomes; UP000002279; Chromosome 7.
DR Bgee; ENSOANG00000015275; Expressed in cerebellum and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0098876; P:vesicle-mediated transport to the plasma membrane; IEA:Ensembl.
DR CDD; cd13273; PH_SWAP-70; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14383:SF2; DIFFERENTIALLY EXPRESSED IN FDCP 6 HOMOLOG; 1.
DR PANTHER; PTHR14383; SWAP-70 RECOMBINASE; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 213..309
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 316..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 72553 MW; 2017DD176BD6D1B1 CRC64;
MELRAELLKS VWYAFTALDV EKSGKVSKSQ LKVLSHNLYT VLNIPHDPVA LEEHFRDDDD
GPVSSQGYMP YLNAHILDKA EEGAFVKERF DELCWTLTAK KNYRPEKGGA GVVSNQDAFR
LWCLFNFLSE DKYPLVMVPD EVEYLLQKVC SSMSLEMGSA ELAELLTPDP PQGGGLSVWQ
FLELVNSSRC LRGVGRDTVS MAIHTVYQEL IQDVLKQGYL WKRGQLRRSW AERWFLLQPN
SLSYYGSEER REQKGSIALD PQCCVEVLPD RDGKRCMFCV KTASRTYEMS AADTRQRQEW
TAAIQTAIRL QVEGKKSLHK DLKQKRREQR ERQERQRVAR EEELARLQQL QEEKERKLQE
LELLQEAQSQ AERLLHEEEE RRRQQHQEMQ KALEGQLREA EQARASMQAE MEQKEEEAAR
QRQRISELEE MQQRLQEALQ LEVKARRDEE AMRSAQTRLL EEEEKKLKQL LQLKEEQEMS
MERARRERQE LRQEMESQSR SLQQAQQQLE QVRQDRQRAD EDVEAAQQKL RQASTNVKHW
NVQMNRLMHP IGPGDKRPPT SSSFAAFQPP LLPRRDSSLK LLQARWEDRA GESPRPCPGE
LQRPLNNGGG CPPGPASAPQ AEPAT
//
