GenomeNet

Database: UniProt
Entry: F6RVE3_HORSE
LinkDB: F6RVE3_HORSE
Original site: F6RVE3_HORSE 
ID   F6RVE3_HORSE            Unreviewed;      1131 AA.
AC   F6RVE3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 49.
DE   SubName: Full=Potassium calcium-activated channel subfamily M alpha 1 {ECO:0000313|Ensembl:ENSECAP00000010310};
GN   Name=KCNMA1 {ECO:0000313|Ensembl:ENSECAP00000010310};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010310, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000010310, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010310,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000010310}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010310};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000010310}.
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DR   STRING; 9796.ENSECAP00000010310; -.
DR   PaxDb; F6RVE3; -.
DR   Ensembl; ENSECAT00000013032; ENSECAP00000010310; ENSECAG00000010713.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   GeneTree; ENSGT00530000063026; -.
DR   InParanoid; F6RVE3; -.
DR   OMA; NRMGQEK; -.
DR   OrthoDB; EOG091G148D; -.
DR   TreeFam; TF314283; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000010713; -.
DR   ExpressionAtlas; F6RVE3; baseline.
DR   GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR   GO; GO:0005901; C:caveola; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0030007; P:cellular potassium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0045794; P:negative regulation of cell volume; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0034465; P:response to carbon monoxide; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0006970; P:response to osmotic stress; IEA:Ensembl.
DR   GO; GO:0060083; P:smooth muscle contraction involved in micturition; IEA:Ensembl.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF28; PTHR10027:SF28; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     20     39       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     59     77       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    142    163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    197       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    209    227       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    233       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1131 AA;  127644 MW;  0F810240FF387B2F CRC64;
     MTSVKDWAGV MISAQTLTGR VLVVLVFALS IGALVIYFID SSNPIESCQN FYKDFTLQID
     MAFNVFFLLY FGLRFIAAND KLWFWLEVNS VVDFFTVPPV FVSVYLNRSW LGLRFLRALR
     LIQFSEILQF LNILKTSNSI KLVNLLSIFI STWLTAAGFI HLVENSGDPW ENFQNNQALT
     YWECVYLLMV TMSTVGYGDV YAKTTLGRLF MVFFILGGLA MFASYVPEII ELIGNRKKYG
     GSYSAVSGRK HIVVDNITLE SVSNFLKDFL HKDDDVNVEI VFLHNISPNL ELEALFKRHF
     TQVEFYQGSV LNPHDLARVK IESADACLIL ANKYCADPDA EDASNIMRVI SIKNYHPKIR
     IITQMLQYHN KAHLLNIPSW NWKEGDDAIC LAELKLGFIA QSCLAQGLST MLANLFSMRS
     FIKIEEDTWQ KYYLEGVSNE MYTEYLSSAF VGLSFPTVCE LCFVKLKLLM IAIEYKSANR
     ESRSRKRILI NPGNHLKIQE GTLGFFIASD AKEVKRAFFY CKACHDDITD PKRIKKCGCK
     RLIYSKMSIY KRMRRACCFD CGRSERDCSC MSGRVRGNMD TLERTFPLSS VSVNDCSTSF
     RAFEDEQPST LSPKKKQRNG GMRNSPSSSP KLMRHDPLLI PGNDQIDNMD SNVKKYDSTG
     MFHWCAPKEI EKVILTRSEA AMTVLSGHVV VCIFGDVSSA LIGLRNLVMP LRASNFHYHE
     LKHIVFVGSI EYLKREWETL HNFPKVSILP GTPLSRADLR AVNINLCDMC VILSANQNNI
     DDTSLQDKEC ILASLNIKSM QFDDSIGVLQ ANSQGFTPPG MDRSSPDNSP VHGMLRQPSI
     TTGVNIPIIT ELVNDTNVQF LDQDDDDDPD TELYLTQPFA CGTAFAVSVL DSLMSATYFN
     DNILTLIRTL VTGGATPELE ALIAEENALR GGYSTPQTLA NRDRCRVAQL ALLDGPFADL
     GDGGCYGDLF CKALKTYNML CFGIYRLRDA HLSTPSQCTK RYVITNPPYE FELVPTDLIF
     CLMQFDHNAG QSRASLSHSS HSSQSSSKKS SSVHSIPSTA NRQNRPKSRE SRDKQNATRM
     NRMGQEKKWF TDEPDNAYPR NIQIKPMANQ INQYKSTSSL IPPIREVEDE C
//
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