ID F6RWR9_CIOIN Unreviewed; 533 AA.
AC F6RWR9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000008353.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000008353.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01002283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6RWR9; -.
DR STRING; 7719.ENSCINP00000008353; -.
DR Ensembl; ENSCINT00000008353.3; ENSCINP00000008353.3; ENSCING00000004050.3.
DR GeneTree; ENSGT00940000169018; -.
DR HOGENOM; CLU_511486_0_0_1; -.
DR InParanoid; F6RWR9; -.
DR OMA; NAERAKW; -.
DR TreeFam; TF315795; -.
DR Proteomes; UP000008144; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd12931; eNOPS_SF; 1.
DR CDD; cd12332; RRM1_p54nrb_like; 1.
DR CDD; cd12333; RRM2_p54nrb_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 6.10.250.1170; -; 1.
DR InterPro; IPR012975; NOPS.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR23189:SF126; FI21126P1-RELATED; 1.
DR PANTHER; PTHR23189; RNA RECOGNITION MOTIF-CONTAINING; 1.
DR Pfam; PF08075; NOPS; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 121..194
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 196..277
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 316..398
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 37..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 61163 MW; 1CEB43289A471FB2 CRC64;
MPANRYGGGG GSGNGRYFNN NNRQDRNYQQ NRRHPPNHQT PMPPPPVPPM MKNSPLPPKM
PVPVPAVDMK KEKSPAKMKV PEPVPPPSLA NETGHSSRNE SNDSHQNASN RPTERKFTQR
SRLFIGNLPT SITEEEFKNL FRPFGEVSET FVNAEKGFGF VRMDTRTNAE RAKWELDGKV
MRSNRQLRVR FATHGAALSV KNISPFVSNE LLEEAFSQFG PVERAVVVVD DRGKSMERGI
VEFARKSSAT KALQQIRDGC FLLTSSPRAV VASTLEQEDT EDGLMERNVS KSQSYFQERE
APPRFAKPNS FEEEFARRWK ALYDLERQQR EHLEKNIQEA KEKLETEMEN AIHDHQTMLM
KQDLLRRQEE LQRLEEARKR ELDRRQELEV ARENARKKEM EGQSQRLDML RAQIEGTYKQ
DMPPHPSMGF NHQPGFGRPG SPLMPPQLHD QLAKELMGGQ GGLAPAPLIK VKSYHHIHSD
MNKLMDSLDK MSDSDQNFYR LAYEHCNNIC TCKAQNYKIE DPMFERLEPC PKS
//
