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Database: UniProt
Entry: F6S7Y0_MONDO
LinkDB: F6S7Y0_MONDO
Original site: F6S7Y0_MONDO 
ID   F6S7Y0_MONDO            Unreviewed;      1986 AA.
AC   F6S7Y0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   25-OCT-2017, entry version 47.
DE   SubName: Full=Kinesin family member 13A {ECO:0000313|Ensembl:ENSMODP00000014035};
GN   Name=KIF13A {ECO:0000313|Ensembl:ENSMODP00000014035};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000014035, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000014035, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000014035}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00283, ECO:0000256|SAAS:SAAS00583243}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000014035}.
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DR   STRING; 13616.ENSMODP00000014035; -.
DR   Ensembl; ENSMODT00000014294; ENSMODP00000014035; ENSMODG00000011220.
DR   eggNOG; ENOG410ISFI; Eukaryota.
DR   eggNOG; KOG0241; Eukaryota.
DR   eggNOG; COG5059; LUCA.
DR   eggNOG; COG5244; LUCA.
DR   GeneTree; ENSGT00890000139327; -.
DR   InParanoid; F6S7Y0; -.
DR   OMA; KLDYHTP; -.
DR   OrthoDB; EOG091G0091; -.
DR   TreeFam; TF105221; -.
DR   Proteomes; UP000002280; Chromosome 3.
DR   Bgee; ENSMODG00000011220; -.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0035459; P:cargo loading into vesicle; IEA:Ensembl.
DR   GO; GO:0000910; P:cytokinesis; IEA:Ensembl.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR   GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0032438; P:melanosome organization; IEA:Ensembl.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0072383; P:plus-end-directed vesicle transport along microtubule; IEA:InterPro.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 2.30.30.190; -; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR032923; KIF13A.
DR   InterPro; IPR022164; Kinesin-like.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR032405; Kinesin_assoc.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008984; SMAD_FHA_domain.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   PANTHER; PTHR24115:SF458; PTHR24115:SF458; 1.
DR   Pfam; PF01302; CAP_GLY; 1.
DR   Pfam; PF12473; DUF3694; 1.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   Pfam; PF16183; Kinesin_assoc; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM01052; CAP_GLY; 1.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF74924; SSF74924; 1.
DR   PROSITE; PS00845; CAP_GLY_1; 1.
DR   PROSITE; PS50245; CAP_GLY_2; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00875240}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00874078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT   DOMAIN        5    352       Kinesin motor. {ECO:0000259|PROSITE:
FT                                PS50067}.
FT   DOMAIN     1878   1920       CAP-Gly. {ECO:0000259|PROSITE:PS50245}.
FT   NP_BIND     102    109       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00283}.
FT   COILED      364    387       {ECO:0000256|SAM:Coils}.
FT   COILED      646    673       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1986 AA;  223023 MW;  57558CDFE56548A4 CRC64;
     MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK PPKVFAFDYC
     FWSMDETNTT KYAGQEEVFK CLGEGILEKA FQGYNACIFA YGQTGSGKSF SMMGNAEQLG
     LIPRLCCALF QRISLEQNES QIFKVEVSYM EIYNEKVRDL LDPKGSRQSL KVREHKVLGP
     YVDGLSQLAV TSFEDIESLM SEGNKSRTVA ATNMNEESSR SHAVFNIIVT QTLYDLQSGN
     SGEKVSKVSL VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKNK
     FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK RIVNHAVVNE
     DPNARVIREL REEVEKLKEQ LSQAEAMKAP ELKEKLEESE KLIKELTVTW EEKLRKTEEI
     AQERQKQLES MGISLETSGI KVGDDKCYLV NLNADPALNE LLVYYLKDHT RIGADTSQDI
     QLFGIGIQPE HCEIDIAPDG DVSLTPKESA RSCVNGTLVC CATQLWHGDR ILWGNNHFFR
     INLPKRKRRD WLKDLEKETG PPEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNGGFPI
     NLYSWWSSRW WSYLKIFFPL MWLQTELLHK RWDKDPVQNV VQVLEKQYLE EKRSALEEQR
     MMYERELEQL RQQLSPERQH QNSGSDRLTF TGQTAQQKVT LWAEERDELF RQSLAKLREQ
     LVKANTLVRE ANFLAEEMNK LTDYQVTLQI PAANLSANRK RGAIVSEPAI QVRRKGKSTQ
     VWNIEKLENK LIDMRDLYQE WKEKVPEVKR LYGKRGDPFY EAQENHNLIG VANVFLECLF
     YDVKLQYAVP IISQQGEVAG RLHIEVMRVT GVVPERVIEG DDSSENSSES GSLEVMDSNG
     DVIHRVKKLT CRVKIKEATG LPLNLSNFVF CQYTFWDQCG STVAAPVVDP DVPSPQSKEP
     QFTVTFSHCE DYVVNVTEEF LEFISEGALA IEVWGHRCTG NGSSIWEVDS LHATTRTLQD
     RWNEVTRRIE MWISILELNE MGEYAAVELH QAKDVNTGGV FQLRQGHSRR VQVTVKPVQH
     SGTLPLMVEA ILSVSIGCVT ARSTKLQRGL DSYQRDDEDG DDMDSYQEED LNFVRERWSD
     ALIKRREYLD EQIKKVSNKK EKTDDDLERE ARLVEQWVGL TEERNAVLVP APGSGIPGAP
     ADWTPPAGME THIPVLFLDL NADDLSANEQ LVGPHASGVN SILPKEHGSQ FFYLPIIKHS
     DDEVSATASW DSSVHDSVHL NRVTPQNERI YLIVKTTVQL SHPAAMELVL RKRIAANVYN
     KQSFTQSLKR RISLKNVFYS CGVTYEIVSN IPKATEEIED RETLALMAAR SENEGTSDGE
     TYIEKYTRGV LQVENILSLE RLRQAVTVKE ALSTKARHIR RSLSTPNVHN VSSSRQDLSG
     CDEDDKGWSE SHLDMSDCSS SYQDVLCYGT LPRDSPRRIK EACASENPHA LTVSPFKAFS
     PQPPKFFKPL MPVKEEHKKK SPLETRPLLS QEDSEEEEHE LETISKKLVS SQPYVPVEFA
     DFSVYNAGLE SREWFSSKAD FLNSRVLEKE VSRSPTTSSI TSGYFSHSAS NATLSDMTVP
     SSDSTDQLAN QMKDLDASEH SGSSLVHDSR PSSNKELAEP EGDLAKDKIS TVTLKENSAL
     VKGSPPSQNS IKKSSKELCR TGSCSGTDSC SSKNNRTPVG FSTREATIEH MSDIVEDHSF
     TEFMGVSDGK DFDGISGPLL SSVGDLSSVK RNPPSKTDAK SNADWLQNLD QPEYEAESEQ
     LLNSTVNPLC SELTKEAPHG QADPDASHHE YFLRKNHLDV SDGEDGLLTE QVYTVPSWMT
     VGEQVCFGNK TGIVRYIGPV DFLTGTWVGV ELNVQMGKHD GTVKGKEYFR CKPQHGIFVR
     PGRLLKASTK KCSNTSRPQA ASSLEKRKSS VVPVPSPSFS KAGEAALCHT GAFREFTDST
     TWEDEK
//
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