GenomeNet

Database: UniProt
Entry: F6S8N4_HORSE
LinkDB: F6S8N4_HORSE
Original site: F6S8N4_HORSE 
ID   F6S8N4_HORSE            Unreviewed;       989 AA.
AC   F6S8N4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 47.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 4 {ECO:0000313|Ensembl:ENSECAP00000022524};
GN   Name=KCNH4 {ECO:0000313|Ensembl:ENSECAP00000022524};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022524, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000022524, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022524,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000022524}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022524};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000022524}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   PaxDb; F6S8N4; -.
DR   Ensembl; ENSECAT00000026939; ENSECAP00000022524; ENSECAG00000024953.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140833; -.
DR   Proteomes; UP000002281; Chromosome 11.
DR   Bgee; ENSECAG00000024953; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    203    223       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    243    263       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    275    292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    332    358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    400    422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    429    453       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     65       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       68    120       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      531    595       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      852    879       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   989 AA;  108507 MW;  9BB0BB7387103888 CRC64;
     TDSNFLLANA QGPRFPIVYC SDGFCELTGY GRTEVMQKTC SCRFLYGPET SEPALQRLHK
     ALEGHQEHRA EICFYRKDGS AFWCLLDMMP IKNEMGEVVL FLFSFKDISQ SGSPGLGPPG
     GHGDSNHENS LGRRGASSRL RSARRQSRTV LRRLTGHFGR RGQGSMKTSN NVFEPKPSVP
     EYKVASVGGS RCLLLHYSVP KAVWDGLILL ATFYVAVTVP YNVCFSDDDD TPITSRHTLV
     SDIVVEMLFI LDIILNFRTT YVSQSGQVVS APRSIGLHYL ATWFFIDLIA ALPFDLLYVF
     NITVTSLVHL LKTVRLLRLL RLLQKLERYS QCSAVVLTLL MSVFALLAHW MACVWYVIGR
     REMEANDPLL WDIGWLHELG KRLEVPYVNG SAGGPSRRSA YIAALYFTLS SLTSVGFGNV
     CANTDAEKIF SICTMLIGAL MHAVVFGNVT AIIQRMYSRR SLYHSRMKDL KDFIRVHRLP
     RTLKQRMLEY FQTTWAVNSG IDANELLRDF PDELRADIAM HLNREILQLP LFGAASRGCL
     RALSLHIKTS FCAPGEYLLR RGDALQAHYY VCSGSLEVLR DSMVLAILGK GDLIGADIPE
     PGQEPGSGAG PSCVLKTSAD VKALTYCGLQ QLSSRGLAEV LRLYPEYGAA FRAGLLRDLT
     FNLRQGSDTN GLSRFSRSPR LSQPHSESLG SSSDKTLPSI TEAEAGAEPG GSSRPRRPIL
     LPNLSPARPR GSLVSLLGEE LPPFSALVSS PSLSPSPSPA LAGGHSPSPL PPQGSAAWEA
     PQLLIPLLGT FGPPDFSPSI VDGIEDSGST AEAPTFRFSR RPEHPRPRSQ APPTGTRPSR
     ELTTEAEEVK EVCRLNQEIS RLNQEVSQLS QELRHMMSLL QARLCPPGHP TVSAWPPDPP
     CPQLRPPCIS PCLSGPRPSL QDTTLAEVHC PASVGTAETG AAPPNLRPSV LSPYPSEPDP
     LVPSPVPEAS PLTPSLRRHS FRSRSDTFH
//
DBGET integrated database retrieval system