ID F6SC67_HORSE Unreviewed; 1832 AA.
AC F6SC67;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Nucleoporin 210 like {ECO:0000313|Ensembl:ENSECAP00000003106.4};
GN Name=NUP210L {ECO:0000313|VGNC:VGNC:20966};
GN Synonyms=TPM3 {ECO:0000313|Ensembl:ENSECAP00000003106.4};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003106.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000003106.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003106.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000003106.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003106.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NUP210 family.
CC {ECO:0000256|ARBA:ARBA00007313}.
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DR STRING; 9796.ENSECAP00000003106; -.
DR PaxDb; 9796-ENSECAP00000003106; -.
DR Ensembl; ENSECAT00000004485.4; ENSECAP00000003106.4; ENSECAG00000002401.4.
DR CTD; 91181; -.
DR VGNC; VGNC:20966; NUP210L.
DR GeneTree; ENSGT00390000009491; -.
DR HOGENOM; CLU_001205_1_1_1; -.
DR InParanoid; F6SC67; -.
DR OMA; GFYYCDI; -.
DR OrthoDB; 6312at2759; -.
DR TreeFam; TF313331; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000002401; Expressed in inner cell mass and 23 other cell types or tissues.
DR ExpressionAtlas; F6SC67; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR Gene3D; 2.60.40.1080; -; 1.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR045197; NUP210-like.
DR PANTHER; PTHR23019:SF1; NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210-LIKE; 1.
DR PANTHER; PTHR23019; NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED; 1.
DR Pfam; PF02368; Big_2; 1.
DR SMART; SM00635; BID_2; 1.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1812..1831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1080..1155
FT /note="BIG2"
FT /evidence="ECO:0000259|SMART:SM00635"
SQ SEQUENCE 1832 AA; 204254 MW; FB673A6AD441A5F3 CRC64;
MTGSGAPRRL GFGLFLCLPL HRLLLLLLFW LGTLANKLNV PQVLLPFGRE PGRVPFLLEA
KRGCYTWHST HHDAVTVEPL YENGTLCSQK AVLIAESTQP IRLSSVILAR EIVTDHELRC
DVKVDVIDSI EIISRTRELY VDDSPLELMV RALDAEGNTF SSLAGMMFEW SIAQDNESAR
EELSSKIRIL KYSEAEYSPP TYIVEMEKEE KQGDMILVSG IRTGAAVIKV RIYEPFYKKV
AAALIRLLVL ENIFLIPSHD IYLLVGAYIK YRVAKMVQGR MTEVDFPLEH YTLELQDRRV
SCNESLSGKV ALLDEKTAMV TAVQLGQINL VFVHKNVHMR SVSGLPNCTI YVVEPGFLGF
TVQPGDRWSL EVGQVYVITV EVFDKSSTKV YISDNLRIMC QFLREYFEEQ LTTANGSYHV
VKALKDGIVV INASLTSIIY QNKNTQPIKF PIVHQQEVKI YFPIKLTPNF LAFPHHPMEM
LYHYKVQVEG GSGNFTWTSF NETVAMVTTK GVVTAGQVRG NSTVLARDVQ NPFRYGEIKI
YVLKLNKMEL LPFHADVEIG QIIEIPIAMY HINKETKEAI AFTDCSHLSL DLNMDKQGVF
TLLKEGIQRP GPTHCSSTHI AAKSLGHTLV TVSVTEYEEY LESSATFAAY EPLKALNPVE
VALVTWQSVK EMVFEGGPRP WILEPSRFFL DLSVEKTEKI EITQVWLPAK RKQNQYIYRV
LCLDLGEQVL TFRIGNHPGV LNPSPAVEVV QVRFICAHPA SMSVTPVYKV PAGAQPCPLP
QHNKQLIPVS SLRDTVLELA VFDQHRRKFD NFSSLMLEWK SSNETLAHFE NYNSVKMVAK
DDGSGQSWLH GHQILKVHQL KGTVLIGVNF VGYSEKKSPK ELFNLPRSAA VELLLVDDVT
VLPENATIYN HPDVKEIFSL VEGSGYFLVN SSKQDIVTIT YLEAESSVQL VPVHPGFLAL
EVYDLCLAFL GPAMAHLRVS DIQELELDLI DKVEIGKTVL VTVRVLGSSK HPFQNKYFRN
MELKLQLASA IVTLTLMEEQ DEYSENYILR AVAIGQSTLV AIARDKMGRK FTSAPRQIEV
FPPFRLVPEK VTLIPTNMMQ VISEGGPQPQ SIIHFSISNQ TVAVVNRRGQ VTGKVVGTAV
VHGTIQTVDE DTGKVIVFSQ DEVQIEVVQL RAVRILAAAT RLITATEMPV YVMGVTSTQT
PFSFSNANPG LTFHWSMSKR DVLDLVPRHS EVFLQLPAEN NFAMVVHTKA AGRTSIKVTV
RHMNSSSGQF EGNLLELSDE VQILVFEKLQ LFYQECQPQQ ILMPMNSQLK LHTNREGAAF
VSSRVLKCFP NSSVIEEDGE GLLKAGSIAG TAVLEVTSIE PFGVNQTTIT GVQVAPVTYL
RMSSQPKLYT AQGKTLSAFP LGMSLTFIVQ FYNSIGEKFH THNTQLYLAL NRDDLLLIGP
GKRNYTYMAQ AVNRGVTLVG LWDRRHPGMA DYIPVAVEHA IEPDTKLTFV GDVICFSTHL
LNQNGEPGIW MISADNILQT DIVTGVGVAR SPGITTIFHD IPGVVKTYRE VVVNASSRLT
LSYDLKTYLT NTPNSTVFKL FITTGRNGVN LKGSCTPSQA LAITRILLPE TLMLCHVQFS
NTLLDIPASK VFHVHSDFSM EKGVYVCLIK VRPQSEELLQ ALSMADTSVY GWATLVSERS
KNGMQRILIP FIPAFYINQS ELVFRHKQDI VEIRVLGVDT VLEKLEVFPS SPVLVVSGHR
HSSLMPGLAI YPVRVVNFTS LQQMASPVFI NISCVLTSQR EAVLARAVKD KSGAAPCEES
GVIQKFMGSY QVLLFTLFAV VASTAFIFLA LN
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