ID F6SDS3_HORSE Unreviewed; 676 AA.
AC F6SDS3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Spartin {ECO:0000313|Ensembl:ENSECAP00000010042.2};
GN Name=SPART {ECO:0000313|Ensembl:ENSECAP00000010042.2,
GN ECO:0000313|VGNC:VGNC:23480};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010042.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010042.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010042.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010042.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010042.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6SDS3; -.
DR STRING; 9796.ENSECAP00000010042; -.
DR PaxDb; 9796-ENSECAP00000010042; -.
DR Ensembl; ENSECAT00000012715.3; ENSECAP00000010042.2; ENSECAG00000012173.3.
DR CTD; 23111; -.
DR VGNC; VGNC:23480; SPART.
DR GeneTree; ENSGT00390000012235; -.
DR HOGENOM; CLU_019310_0_0_1; -.
DR InParanoid; F6SDS3; -.
DR OMA; GRHTAQA; -.
DR OrthoDB; 2907282at2759; -.
DR TreeFam; TF105252; -.
DR Proteomes; UP000002281; Chromosome 17.
DR Bgee; ENSECAG00000012173; Expressed in brainstem and 22 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR CDD; cd02679; MIT_spastin; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR009686; Senescence/spartin_C.
DR InterPro; IPR045036; Spartin-like.
DR PANTHER; PTHR21068; SPARTIN; 1.
DR PANTHER; PTHR21068:SF43; SPARTIN; 1.
DR Pfam; PF06911; Senescence; 1.
DR SMART; SM00745; MIT; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 25..103
FT /note="MIT"
FT /evidence="ECO:0000259|SMART:SM00745"
FT REGION 115..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..143
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 74341 MW; 2DF609AA49DCADD2 CRC64;
MQYLSNHLEM EQEPQNGEPA EIKMIKEAYK KAFLFVNKGL NTDELGQKEE AKNYYKQGIG
HLLRGISISS TEPEHVGPGW ESARQMQQKM KETLQNVRTR LEILEKGLAT SLRNDLQEVP
KLYPEFPPKD TPETSPEPQP FSSPRPHSEE YGSTPATSSG LVPTPSSLSL PSQRHPAEAP
PAYTPQAAEG HYTVSYGTES GEFSSVGEDF YRNHSQPPPL ETLGLDADEL ILIPNGVQIF
FVNPAGEVSA PSYPGYLRIV RFLDNSLDTV LNRPPGFLQV CDWLYPLVPD RSPVLKCTVG
AYMFPDTMLQ ASGCFVGVVL SSELPEDDRE LFEDLLRQMS DLRLQANWIR AEGENEFQIP
GRARCPSDQL KEASGSGTSL DQGNKDVRPK GKRGKKAKDT SSEEVNLSHI VPYEPVSEEK
TKELPEWSEK VAQNILSGAS WVSWGLVKGA EFTGKAIQKG ASKLRERIQP EEKPVEVSPA
VTRGLHIAKQ ATGGAVKVSQ FLVDGVCTVA NCVGKELAPH VKKHGSKLVP ESLKKDRNGK
STLDGAMVVA ASSVQGFSTV WQGLECAAKC IVNNVSAETV QTVRYKYGHT AGEATHDAVD
SAINVGVTAY NIDNIGIKAM VKKTAKQTGH TLLEDYKIID SSKGKNQEER AKVNMKEEKD
EQAEELKKNE AKKKDK
//
