GenomeNet

Database: UniProt
Entry: F6SEY0_HORSE
LinkDB: F6SEY0_HORSE
Original site: F6SEY0_HORSE 
ID   F6SEY0_HORSE            Unreviewed;      4950 AA.
AC   F6SEY0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 46.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSECAP00000022768};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSECAP00000022768};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022768, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000022768, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022768,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000022768}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022768};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000022768}.
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DR   STRING; 9796.ENSECAP00000022768; -.
DR   PaxDb; F6SEY0; -.
DR   Ensembl; ENSECAT00000029145; ENSECAP00000022768; ENSECAG00000006795.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F6SEY0; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000006795; -.
DR   ExpressionAtlas; F6SEY0; baseline.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4264   4286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4483   4503       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4557   4576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4693   4714       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4751   4772       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4827   4850       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    149       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      156    201       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      209    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      335    392       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      583    793       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1321   1546       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4007   4042       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4950 AA;  562689 MW;  7500D25EF145EE09 CRC64;
     MMKWSCSVLP PSTKSSRSYV WQQKGLATDF VSWSPLQIPR MSPQTSPSAP LCWNSPSPSG
     PCRRCWLTRW RSQKGQVDVE KWLFSMQTAQ GGSHRTLLYG HAILLRHSYS GMYLCCLSTS
     RSSTDKLAFD VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV SSERYLHLSY
     GNGSLHVDAA FQQTLWSVAP ISSGSEAAQG YLIGGDVLRL LHGHMDECLT VPSGEHGEEQ
     RRTVHYEGGA VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL SLMEDKNLLL
     MDKEKADVKS TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV NTGLWLTYQS
     VDVKSVRMGS IQRKAIMHHE GHMDDGLNLS RSQHEESRTA RVIRSTVFLF NRFIRGLDAL
     SKKAKASTVD LPIESVSLSL QDLIGYFHPP DEHLEHEDKQ NRLRALKNRQ NLFQEEGMIN
     LVLECIDRLH VYSSAAHFAD VAGREAGESW KSILNSLYEL LAALIRGNRK NCAQFSGSLD
     WLISRLERLE ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR NHKVLDVLCS
     LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG SAQYKKWYYE
     LMVDHTEPFV TAEATHLRVG WASTEGYSPY PGGGEEWGGN GVGDDLFSYG FDGLHLWSGC
     IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG LFFPVVSFSA
     GIKVRFLLGG RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS
     LTQAAFTPIP VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP
     CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGISDEH AEEKVKKMKL PKNYQLTSGY
     KPAPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRVRQGW TYGIQQDVKN RRNPRLVPYA
     LLDDRTKKSN KDSLREAVRT LLGYGYNLEA PDQDHAARAE VCSGTGERFR IFRAEKTYAV
     KAGRWYFEFE AVTAGDMRVG WSRPGCQPDQ ELGSDECAFA FDGFKAQRWH QGNEHYGRSW
     QAGDVVGCMV DMTEHTMMFT LNGEILLDDS GSELAFKDFD VGDGFIPVCS LGVAQVGRMN
     FGKDVSTLKY FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE HIEVTRIDGT
     IDSCPCLKVT QKSFGSQNSS TDIMFYRLSM PIECAEVFSK TAGSGIPGAG LFGPKNDLED
     YDADSDFEVL MKTAHGHLVP DRVDKDKEAT KPEFNNHKDY AQEKPSRLKQ RFLLRRTKPD
     YSTSHSARLT EDVLADDRDD YDYLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG
     FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG
     LLTFTANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL SAGLFKSEHK
     NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCMDPLQ FMSLHIPEEN
     RSVDILELTE QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL YAIENKYMPG
     LLRAGYYDLL IDIHLSSYAT ARLMMNSEFI VPMTEETKSI TLFPDENKKH GLPGIGLSTS
     LRPRMQFSSP SFVSINNDCY QYSPEFPLDI LKAKTIQMLT EAVKQGSLHA RDPVGGTTEF
     LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAS PEEESEALEK EPCAEDSKLE
     GAGDEEAKEG ERPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV AFSDDFVAKL
     QDNQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC PCPEEIRDQL
     LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK PVESDSKKSS
     TLQQLISETM VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY TINGVSVEDT
     INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG MHETVMEVMV
     NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS VGLASPAMRG
     STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS CQMLVSKGYP DIGWNPVEGE
     RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAV MEEAIKIAED
     PSRDGPSPTS GSSRTPDTEE EEDDTIHMGN AIMTFYAALI DLLGRCAPEM HLIHAGKGEA
     IRIRSILRSL IPLGDLVGVI SIGFQMPTIA KDGNVVEPDM SAGFCPDHKA AMVLFLDRVY
     GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP LLTRCAPLFA
     GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ HLLRRLVFDV
     PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW GIFDALSQKK
     YEQELFKLAL PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV DTSNITIPEK
     LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK EKEIYRWPIK
     ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD AAHGYSPRAI DMSNVTLSRD
     LHAMAEMMAE NYHNIWAKKK KLELESKGGG NHPLLVPYDT LTAKEKAKDR EKAQDILKFL
     QINGYVVSRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG SRSKGEHFPY
     EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS LFCKLGVLVR
     HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE DLEKTMENLK
     QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ FGEDLILEDV QVSCYRILTS
     LYALGTSKSI YVERQRSALG ECLAAFAGAF PVAFLETHLD KHNIYSIYNT KSSRERAALN
     LPTNVEDVCP NIPSLEKLME EIVELAESGI RYTQMPHVME VILPMLCSYM SRWWEHGPEN
     NPERTEMCCT ALNSEHMNTL LGNILKIIYN NLGIDEGAWM KRLAVFSQPI INKVKPQLLK
     THFLPLMEKL KKKAAMVVSE EDHLKAEARG DMSEAELLIL DEFTTLARDL YAFYPLLIRF
     VDYNRAKWLK EPNPEAEDLF RMVAEVFIYW SKSHNFKREE QNFVVQNEIN NMSFLITDTK
     SKMSKAAVSD QERKKMKRKG DRYSMQTSLI VAALKRLLPI GLNICAPGDQ ELIALAKNRF
     SMKDTEDEVR DIIRNNIHLQ GKLEDPAIRW QMALYKDLPN RTEDTSDPEK TVERVLDIAN
     VLFHLEQVRF CVDSCHFTQV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA
     VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAEPPEEDE GTKRVDPLHQ LILLFSRTAL
     TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE KEMEKQKLLY QQARLHDRGA
     AEMVLQTISA SKGETGPMVA ATLKLGIAIL NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL
     MQSCSVLDLN AFERQNKAEG LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN
     YLRTQTGNNT TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV
     FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE LLKELMDLQK
     DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF FDMFLKLKDL TSSDTFKEYD
     PDGKGVISKR DFHKAMESHK HYTQSETEFL LSCAETDENE TLDYEEFVKR FHEPAKDIGF
     NVAVLLTNLS EHMPNDTRLQ TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS
     RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERSA
     NKEESEKEKP EEQGPKMGFF SILTVKSALF ALRYNILTLM RMLSLKSLKK QMKKVKKMTV
     KDMVTAFFSS YWSILMSLLH FVASVFRGFS RIICSLLLGG SLVEGAKKIK VAELLANMPD
     PTQDEVRGEG EEGERKPVET ALASEDLTDL KELTEESDLL SDIFGLDLKR EGGQYKLIPH
     NPNAGLSDLM SNPVPIPEVQ DKFQVIYPVA AALWFLDGLY FIRVHRGEDG EKEEKAKEDK
     GKQKLRQLHT HRYGEPEVPE SAFWKKIIAY QQKLLNYFAR NFYNMRMLAL FVAFAINFIL
     LFYKVSTSSV VEGKELPIRS SSENAKVSSL ESSSPRIIAV HYVLEESSGY MEPTLRILAI
     LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT
     QSFPNNYWDK FVKRKVMDKY GEFYGRDRIS ELLGMDKAAL DFSDAREKKK PKKDSSLSAV
     LNSIDVKYQM WKLGVVFTDN SFLYLAWYMT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL
     SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DGDTPDMKCD DMLTCYMFHM
     YVGVRAGGGI GDEIEDPAGD EYEIYRIIFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ
     EQVKEDMETK CFICGIGNDY FDTVPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE
     SYVWKMYQER CWEFFPAGDC FRKQYEDQLN
//
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