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Database: UniProt
Entry: F6SIY2_MACMU
LinkDB: F6SIY2_MACMU
Original site: F6SIY2_MACMU 
ID   F6SIY2_MACMU            Unreviewed;      2013 AA.
AC   F6SIY2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   27-SEP-2017, entry version 40.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1D {ECO:0000313|Ensembl:ENSMMUP00000025311};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000025311, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000025311, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000025311,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000025311}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000025311};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000025311}.
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DR   EMBL; JSUE03023610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03023611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03023612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000027055; ENSMMUP00000025311; ENSMMUG00000019262.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000006718; Chromosome 2.
DR   Bgee; ENSMMUG00000019262; -.
DR   ExpressionAtlas; F6SIY2; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF239; PTHR10037:SF239; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     54     73       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     85    102       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    159    182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    238    259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    271    293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    409    427       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    447    470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    539    558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    611    638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    773    791       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    811    831       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    843    869       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    889    919       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1016   1041       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1095   1113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1125   1145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1212   1230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1304   1327       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1450   1484       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      641    672       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2013 AA;  228827 MW;  618C289C2D8E7F6D CRC64;
     PVKSGEWGQR LGCMAMAAWS PWWSRGRIPV ARQREVLPGT AGDRGAAILE KVEYAFLIIF
     TVETFLKIIA YGLLLHPNAY VRNGWNLLDF VIVIVGLFSV ILEQLTKETE GGNHSSGKSG
     GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI IIYAIIGLEL
     FIGKMHKTCF FADSDIVAEE DPAPCAFSGN GRQCTANGTE CRSGWVGPNG GITNFDNFAF
     AMLTVFQCIT MEGWTDVLYW MNDAMGFELP WVYFVSLVIF GSFFVLNLVL GVLSGEFSKE
     REKAKARGDF QKLREKQQLE EDLKGYLDWI TQAEDIDPEN EEEGGEEGKR NTSMPTSETE
     SVNTENVSGE GETRGCCGSL CNVCLSFSRR WRRWNRFNRR RCRAAVKSVT FYWLVIVLVF
     LNTLTISSEH YNQPDWLTQI QDIANKVLLA LFTCEMLVKM YSLGLQAYFV SLFNRFDCFV
     VCGGITETIL VELEIMSPLG ISVFRCVRLL RIFKVTRHWT SLSNLVASLL NSMKSIASLL
     LLLFLFIIIF SLLGMQLFGG KFNFDETQTK RSTFDNFPQA LLTVFQILTG EDWNAVMYDG
     IMAYGGPSSS GMIVCIYFII LFICGNYILL NVFLAIAVDN LADAESLNTA QKEEAEEKER
     KKIARKESLE NKKNNKPEVN QVANSDNKVT IDDYREEDED KDPYPPCDVP VGEEEEEEEE
     DEPEVPAGPR PRRISELNMK EKIAPIPEGS AFFILSKTNP IRVGCHKLIN HHVFTNLILV
     FIMLSSAALA AEDPIRSHSF RNTMLGYADY VFTGTFAFEI ILKMTTFGAF LHKGAFCRNY
     FNLLDMLVVG VSLVSFGIQS SAISVVKILR VLRVLRPLRA INRAKGLKHV VQCVFVAIRT
     IGNIMIVTTL LQFMFACIGV QLFKGKFYRC TDEAKSNPEE CRGLFILYKD GDVDSPVVRE
     RIWQNSDFNF DNVLSAMMAL FTVSTFEGWP ALLYKAIDSN GENIGPIYNH RVEISIFFII
     YIIIVAFFMM NIFVGFVIVT FQEQGEKEYK NCELDKNQRQ CVEYALKARP LRRYIPKNPY
     QYKFWYVVNS SPFEYMMFVL IMLNTLCLAM QHYEQSKMFN DAMDILNMVF TGVFTVEMVL
     KVIAFKPKHY FTDAWNTFDA LIVVGMLHNS EESNRISITF FRLFRVMRLV KLLSRGEGIR
     TLLWTFIKSF QALPYVALLI AMLFFIYAVI GMQMFGKVAM RDNNQINRNN NFQTFPQAVL
     LLFRCATGEA WQEIMLACLP GKLCDPESDY NPGEEYTCGS NFAIVYFISF YMLCAFLIIN
     LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT LLRRIQPPLG
     FGKLCPHRVA CKVSVLCLTP LGSPGSQNFT QIPPPGNLEQ ANEELRAVIK KIWKKTSMKL
     LDQVVPPAGD DEVTVGKFYA TFLIQDYFRK FKKRKEQGLV GKYPAKNTTI ALQAGLRTLH
     DIGPEIRRAI SCDLQDDEPE ETKREEEDDV FKRNGALLGN HVNHVNSDRR DSLQQTNTTH
     RPLHVQRPSI PPASDTEKPL FPPAGNSVCH NHHNHNSIGK QVPTSTNANL NNANMSKAAH
     GKRPSIGNLE HVSENGHHSS HKHDREPQRR SSVKRTRYYE TYIRSDSGDE QLPTICREDP
     EIHGYFRDPR CFGEQEYFSS EECYEDDSSP TWSRQNYGYY SRYPGRNVDF ERPRGYHHPQ
     GFLEDDDSPI CYDSRRSPRR RLLPPTPASH RRSSFNFECL RRQSSQEEVP SSPTFPHRTA
     LPLHLMQQQI MAVAGLDSSK AQKYSPSHST RSWATPPATP PYRDWTPCYT PLIQVEQSEA
     LDQMNGSLPS LHRSSWYTDE PDISYRTFTP ASLTVPSSFR NKNSDKQRSA DSLVEAVLIS
     EGLGRYARDP KFVSATKHEI ADACDLTIDE MESAASTLLN GNVCPRANGD VGPLSHRQDY
     ELQDFGPGYS DEEPDPGRDE EDLADEMICI TTL
//
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