ID F6SLD1_XENTR Unreviewed; 3340 AA.
AC F6SLD1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Xin actin-binding repeat-containing 2 {ECO:0000313|Ensembl:ENSXETP00000045112};
DE SubName: Full=Xin actin-binding repeat-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_002936796.3};
GN Name=xirp2 {ECO:0000313|Ensembl:ENSXETP00000045112,
GN ECO:0000313|RefSeq:XP_002936796.3,
GN ECO:0000313|Xenbase:XB-GENE-988805};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000045112};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000045112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000045112};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000045112}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002936796.3}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002936796.3};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002936796.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- DOMAIN: Xin repeats bind F-actin. {ECO:0000256|PROSITE-
CC ProRule:PRU00721}.
CC -!- SIMILARITY: Belongs to the Xin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00721}.
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DR RefSeq; XP_002936796.3; XM_002936750.4.
DR Ensembl; ENSXETT00000045112; ENSXETP00000045112; ENSXETG00000020886.
DR KEGG; xtr:100488785; -.
DR AGR; Xenbase:XB-GENE-988805; -.
DR Xenbase; XB-GENE-988805; xirp2.
DR eggNOG; ENOG502QTAC; Eukaryota.
DR HOGENOM; CLU_000319_0_0_1; -.
DR OMA; SDKEICI; -.
DR TreeFam; TF330745; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Bgee; ENSXETG00000020886; Expressed in skeletal muscle tissue and 2 other cell types or tissues.
DR GO; GO:0030054; C:cell junction; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR InterPro; IPR012510; Actin-binding_Xin_repeat.
DR InterPro; IPR030072; XIRP1/XIRP2.
DR PANTHER; PTHR22591; XIN; 1.
DR PANTHER; PTHR22591:SF1; XIN ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08043; Xin; 12.
DR PROSITE; PS51389; XIN; 21.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00721};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT REPEAT 372..387
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 411..426
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 448..463
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 556..571
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 594..609
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 661..676
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 698..713
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 765..780
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 803..818
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 842..857
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 881..896
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 914..929
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 949..964
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 985..1000
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1060..1075
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1098..1113
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1136..1151
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1173..1188
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1238..1253
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1274..1289
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 1309..1324
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1772..1792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2037..2105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2166..2197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2387..2410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2509..2547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2602..2710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2876..2970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3102..3126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3151..3172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3216..3244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2037..2051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2067..2105
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2515..2542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2613..2640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2647..2661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2676..2710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2876..2929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3216..3232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3340 AA; 379696 MW; 5869A38ED12D4AB4 CRC64;
MSESEQNHVP DGINKGKRSQ SEDTTWSGSL DLQETLPLRD RMAMYQAAAS STVQTSTANA
SEDSEARTVP GGLASMKKHF EKSEVASSHR AVTQYQYQQK SIQETRKSKE VTFSCSSSSS
HAAEQRSQFT AANAEQVSVH QQHTHETSTA SNYNQEDDEV ELPKISTQVL KEQFEKSLKE
KGAKTHSSAV SQPKHSKIYN EHPEFEWPVV TTIHSNSANR VQNAVTEETS VHTTSSDNVA
SASFGSLEEF PPPPPPNILE TEELADFSQS PEPPSYAEQQ PCAMSKELYA KQRNLYELKR
LYKHIHPELR KNLQKEFYSE VSDIVANKVE QLGEAKGDVQ QVKYAFENPV GSPQKCISPE
REYLEWDEIL KGEVQSMRWV FENQPLDSIK DESPEPSHIK RIGEQEIIAG GDVKYATWMF
ETKPIDALGV DISTATENIE KVPDLARGDV RTATWLFETQ PLDCLNKIYK EDDLSNTLET
TEEIKGGDVK LGKHLFESTF QNEISSLRLS SELEELKGDV KTTIKQFETE PKYVLKDSSG
KMLEIKTIRR EDVEKGDVKT ARWMFETQPL DTINQDEVEV KVVRGISLEE NLTGGVGKAK
WLFETQALDT IKEVESSVTE KETIIGSDVY QKCWVFETIP MDMLKDNANE RPMQGEEIIG
GDVSNTKYLF ETVPMDELKE SVEVGKLKPI VTMEDEKGDV RHQRWVFETK SLGEIGEDHK
EHVRTVQLDE IHKGDVISCK NAFEKGDLTK SELTYKIAVE DVDKGAVKLN KKLFETTPLY
AIQDRFGHFH EVQTIRKEDI VRGDVQSCQW MFETIPIDQF RERSVENYQI IKGISSEQIQ
SGDVKTGKWL FETQPLDSIK YFSNAEDEEI ITENQTEIVK GDVKMCKWLF ETQQMEDLYE
KQDKISADVD IQRGDVKTCT WLFETQPLDS IHDESEKTET TNQKNIQGRD VQRVCFLFET
ENLDNIQEEG KRDFKRVVEI DIQSGDVSSM KYIFENQPLD KISSSSEEVL QKIKTMNQED
LQNGNVLSCK WLFENHFIDE INEDHVKNKS EFAISDVQGG NVRKGCFIFE TFSLDQITDK
NSEESFTRTI NEEEIIKGDV KNYTLMFETQ PLYAIQDKEG FYHEVTTVKK EEVSHGNVRG
TRWLFETKPL DSFQDSDKVY IIKAVTQEDI QKGDVNSVRY RFETQSLDTI SEDTKSVFRT
IEDVQGGDVK GNKQRFEEED DTNNKYVRTV SISEIKQGNV KTSTWLFETH SVDDIHEEDY
QNIKTVRKED INKGDVKEAV WLFENQNLDS LKEEVENVRE IEKESIPHAD VRTTTWLFET
TPLHEFNEHA FEKQEIIGKS IQGTLKELYS HKIVESHGII LEADEIGDIR MAKYNLMNQD
SPKIQKEEII RGDLQSIMMN LLSENSSAKR IIMLNDEEKG NVSLTKSQLF NRTQDVEEQR
EEIIGGDIQD TIKNLLNIQN FSKQGILIQE SEKGDIKMTV YSLLNQSDQN TMQRDEVIGG
DIKRTISNLK SSGESSENRE RVKIEDSERG NVQFYTTCIE SGALDYLRQL QKSTDESVEI
KEHEEIIGGD VEGTKLQLKR QQFQIERTVD ETDIIPGDVY NTVKVFMTEP EHKSFNVNKE
EVVKGNLRET LNSLSQAVNQ TVIAQKEEII KADLPATLKS LSESQYQTRE TEKADVIPGD
IQGTINSLEK AANIKQELVK EEVVRGNLEA TLKSLQEAQD YVKQVEKEDV ISGNIDITMK
NLRDVSSEKK YVQHQVSMQG DVKNTIKSFS QPSLNVQSQE SKVKNTKKSM QQSEETLTET
EKYAATGGYI TAGHDDQPKS LGTECKNQQS VNAMQKTRNE TLKNDANKVL CQKVESKDTV
CKVTESKLKM KKTETSTAWK KQNTISGTQS AEIISGEKRC LLQGFSEGHK EKTPTDTINQ
SKVMQEAQLS SSINTSKSTA SQQAINVINE SSYQVPDHAH RQVTNHQAQI AQYSTKTLTK
NQVDIQQAEV LDSINNNIEN TEKIEISEKN IQMPKEIKNL EVSNVIKKKS MEEVTVKRKF
GSSKSDHHLQ MKNHPQPAIL RNPKNKPEIY SPPPPPPPPP PPVTETLTAQ LPLPPPPPPL
PLMKSNNEPE YFPSPPPPVT DKMDNEIFPP VTTTLLTEHK EIVNKKVNFQ PYHKQKTQVF
SNNYSTNQLE SRQKSANEQT IKYSEKQRPD VPPKSKLPVF QHKVDDMTIT NKNKSKQEYA
QNATQVSEEQ RRDFKQEIIN QGPLPPKKKV VVPQKISPTF KSESVEVKSK VLDENVSEIN
VQDIDQIMCD QELEKIHNET FKTKESLHLS PTISPHLKPE SPITKSNKQR GITSIINQQN
ISRTEATASH QVQNIQSHDI NLQDLDQAIC DREMERIHEE TLKPKKKVFF PPKSSPLLQP
ATPPPKPKTY IRKFKTPLMI AEEKYRQQRE EMEKNKSKTL CQDIKAEVDE SHVVQATAGS
EVNISVKEES QNVTETTTCS QNLSNQSKEK MIDLLSTNIK ADRESPLAQR AQVKHEPSLQ
IQKKYQTAEH TSEQYVSSKS EGSDNVEKFK QSSFRTISPS LQRMPLNKNI KNVIKPGKLI
QEVSSTESKI QIDNKPHLTK QELAKESHRA HFSETSSQQS VSQSSKQKEQ DASLTVHTKS
SEMETKSKNE GISLTRSQER VQSPKIFKKL QVKKEQSNTD SSSTQIRKLE TSEDVSGHLQ
SQFKSPTQKG LVQESKVAAQ NIVKDKQVHE SEMGEKKKML QSTQESISRK ENSSIDVVEC
IRKCEELQEI IRKINTFELN AQTLSSDTFT TFLSIIPVWL ISDETKKVLT EMATSSNLDY
IREQLSYIKN KTVDMQSYFE KNIHSAIKSS TTVKSRNEAS TYSGIAKKQI STVSKKVESS
NKVIQEKSKM NNDVSRVLSD SRQTECRSCS PSLKTRSPSP TYITIESTAR RTDSPHKERP
QCASPPQKEA TQAPPPPPRS VTPKTTTRSE QLAKLKDTTA KLSHGTQARA VTPIPVVIEK
KCEIVHSPAT LRRQLKIESH ATETICTTPV PTNEVTVSTV GEKTEVYEES RKSEIQKFHS
HQEPKHIPEW VGQEMDTLDV ISITHGSDIP KSHVLATREK TIYSKEKGNS SEKLKSQSKD
ESNKAEAANV HFKTDQGKFQ SEQRKTLQQV KQKSQAELEE SKSQEVVKGK SRNVPIRQIK
DFKDNASKQV YVNRKNRDDM FKPMVHSETM SFAEHVSSVD KRESKTERSR IPPNSETIKP
GFEFKHAPPT YEDVISGHML DISATESPDD ILKNFQKTWE ESERVFKSLG YSVSDTSEMR
SSYHQEEYFT ENASGQGHLH YLSKEGLSNG MPGSRQADLS
//