ID F6SN18_HORSE Unreviewed; 1256 AA.
AC F6SN18;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=STK36 {ECO:0000313|Ensembl:ENSECAP00000008449.4,
GN ECO:0000313|VGNC:VGNC:23693};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008449.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000008449.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008449.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000008449.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008449.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR Ensembl; ENSECAT00000010889.4; ENSECAP00000008449.4; ENSECAG00000010391.4.
DR VGNC; VGNC:23693; STK36.
DR GeneTree; ENSGT00940000158375; -.
DR HOGENOM; CLU_002453_2_0_1; -.
DR TreeFam; TF105340; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000010391; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR ExpressionAtlas; F6SN18; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22983; PROTEIN KINASE RELATED; 1.
DR PANTHER; PTHR22983:SF6; SERINE_THREONINE-PROTEIN KINASE 36; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..195
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 253..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 137196 MW; 7E2EDAF9F76BB8A9 CRC64;
MLKESSFRSW KMMENFLKTS VEAPLRTSYH TLLFPAEHSS LFVQAIAAQL VSALYYLHSH
RILHRDMKPQ NILLAKGGGI KLCDFGFARA MSTNTMVLTS IKGTPLYMSP ELVEERPYDH
TADLWSVGCI LYELAVGTPP FYTTSIFQLV SLILKDPVRW PPTISPCFKN FLQGLLTKDP
RQRLSWPDLL HHPFIAGHVT IITEPAGSDL GTPFTSRLPP ELQVLKDQQA HRLVPKGNQF
RILRQACKRM AEELKQKRHQ NTGPALEQED RTSKVASGTA SPPRLRATPQ ESGLLAGILA
SEMKSSWAEC GAGEDPPAPR ENWTTQDCER AFPELRPEVM GQQSIDAVDL ENEEPDSDDE
WKHLLETSKP MPIQLKAPLT LLCNPDFCQR IQAQLHEAAG QILKGMLEGA SQILPALRVL
SSLLSSCSDS VPLYSFCREA GLPGLLLSLL RHSQENNSIQ QQCWCGTFLQ DLMAVIQAYF
ACTFNLERSQ TGDSLQVFQE AANHFLDLLG KLLAQPDDSE QNLWRDSLMC FIVLCEAMDG
NSWTVAKAFY CSLLTTQRAV LDGLLHGLTV LQLPVHSPPG APQVSQPLRE QSADLPGALS
SALAAICTTP VGLPGCWKAK EQITRHLANQ LIEDSTQLRP SIISGLKHPI LCLHLLKILY
SCCHISEHLC HLLVQEPLAL ESLLMLVRGK VKVVDWEESA EVTLYLLSLL VLRLQDLPSG
MEKLGGEIAT VFTRSHVVSL VSAAACLLGQ LGQQGVPFDL QPVEWIAAAT HALSAPAEVR
LTPPDGCGFY DGLFILLLQL LSQEGKGSLI REVASSEMWT VLWQRFSMAL RLPEEVSAQE
EELSLCSPQS PGPDWTLISP QGMAALLSLA VASFTQEPQL CLSHLSQRGS ILMSTLKHLL
SPSFLHQLGQ APHGSEFLPV MVLSVCQLLC FPFALDVDAD LLVGVLADLT NSEVTAHLLQ
VCCHHLPLPQ VELPISLLTH LALMDSTSLN QFVNTVAASP RSMISFLSIA LLGDQPLLTS
DLLSLLAHTV RVLSPSHLSF IQELLAGSDE SYRPLRSLLG HPENSVRART YGLLGHLLQH
SMALRGALQS QTGLLNLLLL GLGDKDPAVR RSASFAVGNA AYQAGPLGPA LAAAVPGMTQ
LLGDPQAGIR RNAASALGNL GPEGLGEELL QCQVPQRLLE MACGDPQPNV KEAALIALRS
LRQEPCIHQV LVSLGASEKL ALLSLGNPSL PHSSPRPASA KHCRKLIHLL RPTHST
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