GenomeNet

Database: UniProt
Entry: F6SSI2_CIOIN
LinkDB: F6SSI2_CIOIN
Original site: F6SSI2_CIOIN 
ID   F6SSI2_CIOIN            Unreviewed;      1518 AA.
AC   F6SSI2; A0A1W2W570;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   SubName: Full=Protein unc-13 homolog B-like {ECO:0000313|Ensembl:ENSCINP00000004445.2};
GN   Name=LOC100176945 {ECO:0000313|Ensembl:ENSCINP00000004445.2};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000004445.2, ECO:0000313|Proteomes:UP000008144};
RN   [1] {ECO:0000313|Proteomes:UP000008144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12481130; DOI=10.1126/science.1080049;
RA   Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA   Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA   Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA   Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA   Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA   Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA   Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA   Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA   Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA   Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA   Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA   Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA   Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA   Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA   Satoh N., Rokhsar D.S.;
RT   "The draft genome of Ciona intestinalis: insights into chordate and
RT   vertebrate origins.";
RL   Science 298:2157-2167(2002).
RN   [2] {ECO:0000313|Ensembl:ENSCINP00000004445.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EAAA01001620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002124363.1; XM_002124327.4.
DR   STRING; 7719.ENSCINP00000004445; -.
DR   Ensembl; ENSCINT00000004445.2; ENSCINP00000004445.2; ENSCING00000002173.2.
DR   GeneID; 100176945; -.
DR   KEGG; cin:100176945; -.
DR   GeneTree; ENSGT00940000168389; -.
DR   HOGENOM; CLU_001304_3_0_1; -.
DR   InParanoid; F6SSI2; -.
DR   OMA; IVMHTME; -.
DR   OrthoDB; 5395569at2759; -.
DR   TreeFam; TF312844; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098831; C:presynaptic active zone cytoplasmic component; IBA:GO_Central.
DR   GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0043195; C:terminal bouton; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR   GO; GO:0061789; P:dense core granule priming; IBA:GO_Central.
DR   GO; GO:0007528; P:neuromuscular junction development; IBA:GO_Central.
DR   GO; GO:0099525; P:presynaptic dense core vesicle exocytosis; IBA:GO_Central.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; IBA:GO_Central.
DR   GO; GO:0016081; P:synaptic vesicle docking; IBA:GO_Central.
DR   GO; GO:0016188; P:synaptic vesicle maturation; IBA:GO_Central.
DR   GO; GO:0016082; P:synaptic vesicle priming; IBA:GO_Central.
DR   CDD; cd08394; C2A_Munc13; 1.
DR   CDD; cd04027; C2B_Munc13; 1.
DR   CDD; cd08395; C2C_Munc13; 1.
DR   Gene3D; 1.10.357.50; -; 1.
DR   Gene3D; 1.20.58.1100; -; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 3.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR010439; MUN_dom.
DR   InterPro; IPR014770; Munc13_1.
DR   InterPro; IPR014772; Munc13_dom-2.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR027080; Unc-13.
DR   InterPro; IPR037302; Unc-13_C2B.
DR   PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR   PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00168; C2; 3.
DR   Pfam; PF06292; MUN; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00239; C2; 3.
DR   SMART; SM01145; DUF1041; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   PROSITE; PS50004; C2; 3.
DR   PROSITE; PS51258; MHD1; 1.
DR   PROSITE; PS51259; MHD2; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          1..97
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          406..456
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          512..636
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          938..1081
FT                   /note="MHD1"
FT                   /evidence="ECO:0000259|PROSITE:PS51258"
FT   DOMAIN          1190..1332
FT                   /note="MHD2"
FT                   /evidence="ECO:0000259|PROSITE:PS51259"
FT   DOMAIN          1347..1474
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          195..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1518 AA;  172422 MW;  E895F40A02704BC8 CRC64;
     MSLLCVKVKQ GKLDGAPDKF NTYVSLKVQN VKSTTICVKG CDPLWEQDYM FEISRVDLGL
     SIEIWNKGVL WDTLLGTAWL PLSHVPHCNE EGDGAWYQLY TNVNSDKGVV PDVKNATNHK
     VLCDVRFELP CELSENEVVM LQQKLDEFNE YQDDTWMVDP FSSTLNKSNA TSSISIDSDY
     RSDVSVVGSY QTVQHANASS SQHREARALK KPKAGSLTTD EADSYSREYG SDTESFDSRC
     QRYGSEEDAE ADRQVGQEDV GLVLKHESYE DSPPKIPDDL ANSAGDMSFS SAKFKWIHAF
     NRVRIGLNGE REDQLGELHC SRKASLWNIG ANSSFYTSID SMPDIRPRKK SIPLVSDLSI
     AMIKRQTGIT SALVTSRASL NDEDLKLHVY KKTLQALIYP ISCTTPHKFA IWSASTPTYC
     YECEGLLWGI ARQGLRCSEC GVKCHEKCRD LLNADCLHRA AEKSSKHGAE DKTQHIITSM
     KDRMKVRENS CPQLFQLMKS VFDVNYDSHH ILMESAKQCV LDGTSKWSAK LSITVISAQG
     LQAKDKTGSS DPYVTVQVGK TRKRTKTIYG DLNPLWNENF HFECHNSTDR IKVRVWDEDD
     DIKSVLKQQF KRESDDFLGQ TIIEVRTLSG EMDVWYNLEK RTDKSAVSGA IRLHINMEIK
     GEEKVAPYHL QYTCLHENLF HYTCKQNNDM VKIPKMDGEE SWKVYFDGQQ QEIVDEFAMR
     YGVESIYQAM THFSCLSSKY KSSGAPAVMS ALLANINAYY AHTSPTTHIS ASNRFAASNF
     GTERFVKLLD QLHNSLRIDL SMYRKHFPAS KPEKLIDLKS TVDLLTSITF FRMKVQELQS
     PPRAGQVVKD CCKACIRSTY GYVFSNCSEI SQTDKTEEGP EEGGPRIDDL DFWTQLITLM
     VSVIEEDKNI YTNYLNQFPS EFNVGQVCAG EMWKMFSEDL EKGLLEHAQH RLCKTTDYMN
     LQFKVKWLYK EYVAPLDMFQ DAVPEYSQWF EPFTMDWLDV NEKLSMDFLS GAYERDRRDS
     FQQSSEHALF SCSVVDIFTQ LNQSYDIIKK LECPDPQVVN QFMTKFAKTI EKVLDTYAEM
     VSKDFPKLCA KEDTACVLMN NIQQLRVLLE NLFRNMGGEQ LDSVTSDILK SLQVKLNVRL
     GELSEIFGQS FTQRIDNSIK AMGNLLCKIK GNANISIQQR SSDNIAHEAD NVLRPLMDLL
     NGSLEMFAKT CEKTVLKHVL KELWKLVVKS LETSIVLPPL NDITGSQLLR NAAKEISQFS
     KFRDLAREDV SRNLSPRQCY ILDASLDSIK QYFHAGGKGL RKNYLEKSEE LQSLKYALSL
     YTQTTDSLIK TFIETQTTQD EPSVESPQGE VSIQVDIYTH PGTGENKLTI KVVAASNLKW
     NTTGMFRPFV DVNLVGPHLS NVRRRYSTKS RSNAWSPKYN ESFSYSIGNV EKISAYELHL
     CVKDYCFARD DRVIGVAVMQ LRNISQQGSC ACWCSLGKNI HLNQTGWTVL RILSQRAGDE
     IAKEFVQLKS STRSLEEA
//
DBGET integrated database retrieval system