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Database: UniProt
Entry: F6T0R5_HORSE
LinkDB: F6T0R5_HORSE
Original site: F6T0R5_HORSE 
ID   F6T0R5_HORSE            Unreviewed;       823 AA.
AC   F6T0R5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 25.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSECAP00000008680};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008680, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000008680, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008680,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000008680}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008680};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000008680}.
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DR   Ensembl; ENSECAT00000011143; ENSECAP00000008680; ENSECAG00000010196.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000002281; Chromosome 12.
DR   Bgee; ENSECAG00000010196; -.
DR   ExpressionAtlas; F6T0R5; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    392    417       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    438    455       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    531    549       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    569    587       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    630    650       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    761    786       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   823 AA;  91957 MW;  715ABE9DFAB0113B CRC64;
     MGSMFRSEEV ALVQLFLPTA AAYTCVSQLG ELGLVEFRDL NASVSAFQRR FVMDVRRCEE
     LEKTFTFLQE EVWRAGLALS PPEGALPAPP PRDLLRIQEE TDRLAQELRD VRGNQQTLRA
     QLHQLQLHEA VLGQGHCPPL VATDTDRSSE RTPLLQDPRG PHQDLRVNFV ASAVEPHKAA
     ALERLLWRAC RGFLIASFRE TEQPLQDPVT GEPATWMTFL ISYWGEQIGQ KILKITNCFH
     CHVFPFEEQE EARHAALQQL QQQTHELLEV LETERFLSQP SADSQGPWDG PSQPMKSETR
     SQGRCSVNRP QAAGAQEGRA APTMLPSQLG LAGGRGEAGV SAVVHRPCRD MPPTLVRTNR
     FTASFQGIVD AYGVGRYQEV NPAPYTIVTF PFLFAVMFGD VGHGLLMFLF ALAMVLAENR
     PAVKTAQNEI WRTFFGGRYL LLLMGLFSVY TGFIYNECFS RATVIFRSGW NVSAMVDQSG
     WSDEFLAQHP LLTLDPNVSG VFRGPYPFGI DPVWSLAVNH LSFLNSFKMK MSVILGVTHM
     AFGVVLGVFN HLHFRQPYRL LLETLPELVF LLGLFGYLVF LVFYKWLCYT SASAASAPSI
     LIHFINMFLF SRSPTNRPLF TGQEMVQSAL VVLGPAMVPV LLLGTPLFLF RQHRRRSRKR
     PTGRQLDEDQ TGLLDASNPS EAAWGSDEEK AGCPGPEEEA EFVPSEVVMH QAIHTIEFCL
     GCISNTASYL RLWALSLAHA QLSEVLWAMV MRTGLRMGNK IGVMAVVLVP IFAAFAVLTV
     AILLVMEGLS AFLHALRLHW VEFQNKFYSG TGYKLSPFSF AVE
//
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