ID F6T4U9_HORSE Unreviewed; 733 AA.
AC F6T4U9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Chondroadherin like {ECO:0000313|Ensembl:ENSECAP00000020567.2};
GN Name=CHADL {ECO:0000313|Ensembl:ENSECAP00000020567.2,
GN ECO:0000313|VGNC:VGNC:16475};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020567.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020567.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020567.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020567.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020567.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|PIRNR:PIRNR037595}.
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DR AlphaFoldDB; F6T4U9; -.
DR Ensembl; ENSECAT00000024739.2; ENSECAP00000020567.2; ENSECAG00000023119.4.
DR VGNC; VGNC:16475; CHADL.
DR GeneTree; ENSGT00940000154464; -.
DR HOGENOM; CLU_022061_0_0_1; -.
DR TreeFam; TF337463; -.
DR Proteomes; UP000002281; Chromosome 28.
DR Bgee; ENSECAG00000023119; Expressed in articular cartilage of joint and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR017241; Toll-like_receptor.
DR PANTHER; PTHR24373:SF276; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3B; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 7.
DR Pfam; PF01463; LRRCT; 2.
DR PIRSF; PIRSF037595; Toll-like_receptor; 6.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00369; LRR_TYP; 19.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00013; LRRNT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..733
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018765459"
FT DOMAIN 29..63
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 307..355
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 387..421
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 667..715
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 361..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 79769 MW; 9678C42A535E47F4 CRC64;
MEGSQGLSLV LLLPLLLLLG PTWQATGQRC PWTCVCDNSR RHVACRHQNL TEVPNAIPEL
TQRLDLQGNM LKVIPPAAFQ DLPYLTHLDL RHCQVELVAE GAFRGLGRLL LLNLASNRLT
ALPQEALDGL GSLRRLELEG NMLEELRPGT FGALGALATL NLARNALVYL PAMAFQGLLR
TRWLQLSHNA LSVLAPEALA GLPALRRLSL HHNELQALPG LALSQAQGLV HLELGHNPFT
YMGEEDGLAL PSLRELMLDH GALQALDPRA FAHCPHLHTL DLRGNQLDTL LPLQVPGQLR
RLWLQGNPLW CGCQARPLLE WLARARVRSD GACRGPRRLR GEALDALRPL DLRCPGDGAE
EEEEELAALR PRGPPSTPKE EDGAAKPCPH VCVCASESRH SGCEGQGLQA VPRGFPNDTQ
LLDLRQNHFS LVPRAAFPGL GLLVSLHLQH CGITELEAGA LAGLGSLMYL YLSDNQLSGL
SAAALEGAPR LGYLYLERNR FLQVPGAALR ALPSLFSLHL QDNAVDRLAP GDLAGVRALR
WLYLSGNRIT QVSPGALGPA RELEKLHLDR NQLREVPTEA LEGLPALLEL QLSGNLLRTL
SHEAFRPVGR SLQHLFLNSS GLEQISPGAF SGLGPQLQSL YLQKNQLQAL PALPGLSQLE
LIDLSGNPFR CDCQLLPLHR WLTGLNLRVG ATCAAPPRAR GQRVKAAAAV FEACPGWAAR
KAKRTPSARR ITP
//
