ID F6T8M0_HORSE Unreviewed; 1569 AA.
AC F6T8M0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Rap guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSECAP00000018739.4};
GN Name=RAPGEF6 {ECO:0000313|VGNC:VGNC:110123};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018739.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018739.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018739.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018739.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018739.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014585805.1; XM_014730319.1.
DR Ensembl; ENSECAT00000022661.4; ENSECAP00000018739.4; ENSECAG00000021067.5.
DR VGNC; VGNC:110123; RAPGEF6.
DR GeneTree; ENSGT00940000158124; -.
DR HOGENOM; CLU_002782_0_0_1; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000021067; Expressed in inner cell mass and 23 other cell types or tissues.
DR ExpressionAtlas; F6T8M0; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR PANTHER; PTHR45161:SF4; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 235..335
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 367..481
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 485..555
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 704..790
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 815..1042
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1569 AA; 176013 MW; AB2CF5C843FFC768 CRC64;
MNSPVDPGTR QALKKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLLS ARARYERYSG
NQILFCSETI ARCWYILLSG SVLMKDSMVL PPCSFGKQFG GKRGCDCLVL EPSEMIVVEN
SKDNEDFLHR EIPARQSRRR FRKINYKGER QTITDDVDIN SYLSATESEV GDVDLTRLPE
GPVDSEDEEE EDEEIDRTDP LQGRDLVREC LEKEPADKTD DDIEQLLEFM HQLPAFANMT
MSVRRELCSV MIFEVVEQAG AIILEDGQEL DSWYVILNGT VEIIHPDGKV ENLFMGNSFG
ITPTLDKQYM HGVVRTKVDD CQFVCIAQQD YWRILNHVEK NTHKVEEEGE IVMVHEHREL
DRSGTRKGHI VIKATPERLI MHLIEEHSIV DPTYIEDFLL TYRTFLESPL DVGVKLLEWF
KIDSLRDKVT RIVLLWVNNH FNDFEGDPAM TRFLEEFEKN LEDTKMNGHL RLLNIACAAK
AKWRQVVLQK ASRESPLHFS LSGGSEKGFG IFVEGVEPSS KAADAGLKRG DQIMEVNGQN
FENITFVKAL EILRNNTHLA LTVKTNIFVF KELLSRTEQE KSGVPHIPKI AEKKSNRHSI
QDVPGDIEQT SQEKGNKKVK ANTVSGGRNK IRKILDKTRF SILPPKLFSD GGLSQSQDDS
IVGTRHCRHS LAIMPIPGTL SSSSPDLLQP TTSMLDFSNP SDIPDQVIRV FKADQQSCYI
IISKDTTAKE VVCHAVHEFG LSGASDTYSL CEVSVTPEGV IKQRRLPDQF SKLADRIQLN
GRYYLKNNME TETLCSDEDA QELVKESQLS MLQLSTIEVA TQLSMRDFDL FRNIEPTEYI
DDLFKLDSKT GNTHLKEFED IVNQETFWVA TEILTESNQL KRMKLIKHFI KIALHCRECK
NFNSMFAVIS GLNLSSVARL RGTWEKLPSK YEKHLQDLQD LFDPSRNMAK YRNVLSSQSM
QPPIIPLYPV VKKDMTFLHE GNDSKVDGLV NFEKLRMIAR EIRQVVRMTS ANMDPAMMFR
QRKKRWRSLG SLSQGSTNSN MLDVQGGAHK KRARRSSLLN AKKLYEDAQM ARKVKQYLSS
LDVETDEEKF QMMSLQCEPA YSTLTKNLNE KRSAKSSEMS PVPTRSSGQA AKAHLHQPHR
VSQVLQVPAV NLHPMRKKGQ AKDPATLSTG LPQKVLGTTE EISGKKHTED TISMASSLHS
SPPASPQGSP RKGYTLIPSA KSDNLSDSSH SEISSRSSIV SNCSVDSMSA ALQDERCSSQ
AVAVPESTGA LEKTEHSSGA GDHSHLSPGW TLSKPSLVKS LAVSSSMSNE EISHEHIIIE
AADSGRGSWT SCSSSSHDNF QNLPNPKGWD FLNSYRHTHL DGPIAEVEPT DCEPYSCPKG
CSRTCGQNKG SLETNQVRQS WASSSSLSDT YEPNYGTVKR RVLESTPGES SEGLELKDGT
DSVYKTVTSS TEKGLIVYCV TSPKKEDRYR EPPPTPPGYM GISLADLKEG PHLHLKPPDY
SVAVQRSKMM HNSLSRLPPA SLSSNPVACV PSKIVTQPQR HNLQPSHPKV AAVTDADSEA
DENEQVSAV
//
