GenomeNet

Database: UniProt
Entry: F6TEN5_HORSE
LinkDB: F6TEN5_HORSE
Original site: F6TEN5_HORSE 
ID   F6TEN5_HORSE            Unreviewed;      4846 AA.
AC   F6TEN5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSECAP00000013164};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSECAP00000013164};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013164, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013164, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013164,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013164}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013164};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000013164}.
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DR   PaxDb; F6TEN5; -.
DR   Ensembl; ENSECAT00000016301; ENSECAP00000013164; ENSECAG00000013267.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000013267; -.
DR   ExpressionAtlas; F6TEN5; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4159   4183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4387   4407       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4455   4474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4586   4604       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4647   4668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4727   4750       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      568    779       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      995   1191       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1237   1449       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3894   3929       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4846 AA;  549610 MW;  75C7A9383F6C20B6 CRC64;
     EDEVVLQCIA NVHKEQRKFC LAAEGLGNRL CFLEPTSEAK YVPPDLCVCN FVLEQSLSVR
     ALQEMLANTG ENGGEGAAQG GGHRTLLYGH AILLRHSFSG MYLTCLTTSR SQTDKLAFDV
     GLREHATGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVF SERYLHLSIS NGNIQVDASF
     MQTLWNVHPT CSGSSIEEGY LLGGHVVRLF HGHDECLTIP STDQNDSQHR RVFYEAGGAG
     TRARSLWRVE PLRISWSGSN IRWGQAFRLR HLTTGHYLAL TEDQGLILQD RGKSDTKSTA
     FSFRASKEIK EKLDSSHKRD IEGMGVPEIK YGDSVCFVQH VSSGLWVTYK AQDAKTSRLG
     PLKRKVILHQ EGHMDDGLTL QRCQQEESQA ARIIRNTTAL FSQFVSGNNR TTAPVTLPIE
     EVLQTLQDLI AYFQPPEEEM QHEDKQNKLR SLKNRQNLFK EEGMLALVLN CIDRLNIYNS
     VAHFAGIARE ESGMAWKEIL NLLYKLLAAL IRGNRNNCAQ FSNNLDWLIS KLDRLESSSG
     ILEVLHCILI ESPEALNLIA EGHIKSIISL LDKHGRNHKV LDVLCSLCLC NGVAVRANQN
     LICDNLLPRR NLLLQTRLIN DVTSIRPNIF LGVAEGSAQY KKWYFELIID QVDPFLTAEP
     THLRVGWASS SGYAPYPGGG EGWGGNGVGD DLYSYGFDGL HLWSGRIPRA VASINQHLLK
     SDDVVSCCLD LGVPSISFRI NGQPVQGMFE NFNTDGLFFP VVSFSAGVKV RFLMGGRHGE
     FKFLPPTGYA PCYEALLPKE KMRLEPVKEY KRDAEGVRDL LGTTQFLSQA SFIPCPIDTS
     QVVLPPHLEK IRDRLAENIH ELWGMNKIEL GWTFGKIRDD NKRQHPCLVE FSKLPETEKN
     YNLQMSTETL KTLLALGCHI AHVNPAAEED LKKVKLPKNY MMSNGYKPAP LDLSDVKLLP
     PQEILVDKLA ENAHNVWAKD RIKQGWTYGI QQDLKNKRNP RLVPYALLDE RTKKSNRDSL
     REAVRTFVGY GYNIEPSDQE LADPAVEKVS IDKIRFFRVE RSYAVRSGKW YFEFEVVTGG
     DMRVGWARPG CRPDVELGAD DQAFVFEGSR GQRWHQGSGY FGRTWQPGDV VGCMINLDDA
     SMIFTLNGEL LITNKGSELA FADYEIENGF VPICSLGLSQ IGRMNLGMDA STFKFYTMCG
     LQEGFEPFAV NMNRDVAMWF SKRLPTFVNV PKDHPHIEVV RIDGTMDSPP CLKVTHKTFG
     TQNSNANMIY CRLSMPVECH ASFSHSPCLD SDAFQKRKQM QEILSHTTTQ CYYTIRIFAG
     QDPSCVWVGW VTPDYHLYSE KFDLNKNCTV TVTLGDERGR VHESVKRSNC YMVWGGDIVA
     TSQRSSRSNV DLEIGCLVDL AMGMLSFSAN GRELGTCYQV EPNTKVFPAV FLQPTSTALF
     QFELGKLKNA MPLSAAIFKS EEKNPVPQCP PRLDIQTIQP VLWSRMPNSF LKVETERVSE
     RHGWVVQCLE PLQMMALHIP EENRCVDILE LCEQEDLMLF HYHTLRLYSA VCALGNSRVA
     YALCSHVDLS QLFYAIDNKY LPGLLRSGFY DLLISIHLAS AKERKQMMKN EYIIPITSST
     GKIRLYPDES KRHGLPGVGL RTCLKPGFRF STPCFVVTSE EHQKQSPEIP LEILKTKALS
     MLTEAVQCSG AHIRDPVGGS VEFQFVPVLK LIGTLLVMGV FDDDSVRQIL LLIDPSVFGE
     HSGEMEEGAE KEEVTQVEEK AVEAGEKASK EAPVKGLLQT RLPESVKLQM CELLSYLCDC
     ELQHRVEAIV AFGDIYVSKL QANQKFRYNE LMQALNMSAA LTARKTREFR SPPQEQINML
     LNFQLGENCP CPEEIREELY DFHEDLLIHC GVPLEEEEEE EEDTSWTGKL RALVYKIKGP
     PKPEKELPTE EEERCPTTLK ELISQTMIRW AQEDQIQDAE LVRMMFNLLR RQYDSIGELL
     QALRKTYTIS QASVSDTINL LAALGQIRCL LSVRMGKEEE LLMINGLGEI MNNKVFYQHP
     NLMRVLGMHE TVMEVMVNVL GAEKSQIAFP KMVASCCRFL CYFCRISRQN QKAMFEHLSY
     LLENSSVGLA SPSMRGFTPL DVAASSVMDN NELALGLEEP DLEKVVTYLA GCGLQSCPML
     LAKGYPDVGW NPIEGERYLS FLRFAVFVNS ESVEENASVV VKLLIRRPEC FGPALRGEGG
     NGLLAAMQGA IKISENPALD LPSQGYKREV STEDAEDDEI VHMGNAIMSF YSALIDLLGR
     CAPEMHLIQT GKGEAIRIRS ILRSLVPTED LVGIISIPLK LPSLNKDGSV SEPDMAANFC
     PDHKAPMVLF LDRVYGIKDQ TFLLHLLEVG FLPDLRASAS LDTVSLSTTE AALALNRYLC
     SAVLPLLTRC APLFAGTEHY TSLIDSTLQT IYRLSKGRSL TKAQRDTIEE CLLAICNHLR
     PSMLQQLLRR LVFDVPQLNE YCKMPLKLLT NHYEQCWKYY CLPSGWGSYG LAVEEELHLT
     EKLFWGIFDS LSHKKYDQDL FRMALPCLSA IAGALPPDYL DTRISATLEK QVSVDADGNF
     DPKPINTVNF SLPEKLEYIV TKYAEHSHDK WACDKSLNRW KYGISLDENV KTHPLIRPFT
     LTEKEKEIYR WPARESLKTM LAVGWTIERT KEGEALVQQR ENEKLRSVSQ ASQGNSYSPA
     PLDLSNVVLS RELQGMVEVV AENYHNIWAK KKKLELESKG GGSHPLLVPY DTLTAKEKFR
     DREKAQDLFK FLQVNGIVVS RGMKDMELDA SSMEKRFAYK FLKKILKYVD SAQEFIAHLE
     AIVSSGKTEK SPHDQEIKFF AKVLLPLVDQ YFTNHRLYFL SSPLKPLSSS GYASHKEKEM
     VASLFCKLAA LVRHRISLFG NDSTTMVSCL HILAQTLDTR TVMKSGSELV KAGLRAFFEN
     AAEDLEKTSE NLKLGKFTHS RTQIKGVSQN INYTTVALLP ILTSIFEHVA QHQFGVDLLL
     GDVQISCYHI LCSLYSLGTG KNIYVERQRP ALGECLASLA AAIPVAFLEP TLNRYNPLSV
     FNTKTPRERS ILGMPDTVEE MCPDVPQLEG LMKEINDLAE SGARYTEMPH VIEVILPMLC
     NYLSYWWERG PEHLPPSTGP WCTKVTSEHL SVTLGNILKI INNNLGIDEA SWMKRIAVYA
     QPIISKARPG LLRSHFLPTL EKLKKKAVKT VQEEEQLKAD SKGDTQEAEL LILDEFAVLC
     RDLYAFYPML IRYVDNNRSN WLKSPDAYSD QLFRMVAEIF ILWCKSHNFK REEQNFVIQN
     EINNLAFLTG DSKSKMSKSG GQDQERKKTK RRGDLYSIQT SLIVAALKKM LPIGLNMCTP
     GDQELISLAK SRYSYKDTDE EVKEHLRNNL HLQEKSDDPA VKWQLNLYKD VLKSEEPSNP
     EKTVERVQRI SAAVFHLEQV EQPLRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPHRSI
     NLFLHGYQRF WIETEEYSFE EKLVQDLAKS PKVEEEEEEE TEKQPDPLHQ IILHFSRNAL
     TERSKLEDDP LYTSYSSMMA KSCQSGEEEE EEEDKEKTFE EKEMEKQKTL YQQARLHERG
     AAEMVLQMIS ASKGEMSPMV VETLKLGIAI LNGGNAGVQQ KMLDYLKEKK DAGFFQSLSG
     LMQSCSVLDL NAFERQNKAE GLGMVTEEGT LIVRERGEKI LQNDEFTRDL FRFLQLLCEG
     HNSDFQNFLR TQMGNTTTVN VIISTVDYLL RLQESISDFY WYYSGKDIID ESGQHNFSKA
     LAVTKQIFNS LTEYIQGPCI GNQQSLAHSR LWDAVVGFLH VFANMQMKLS QDSSQIELLK
     ELLDLLQDMV VMLLSLLEGN VVNGTIGKQM VDTLVESSTN VEMILKFFDM FLKLKDLTSS
     DTFKEYDPDG KGIISKKEFQ KAMEGQKQYI QSEIDFLLSC AEADENDMFN YIDFVDRFHE
     PAKDIGFNVA VLLTNLSEHM PNDSRLKSLL DPAESVLNYF EPYLGRIEIM GGAKKIERVY
     FEISESSRTQ WEKPQVKESK RQFIFDVVNE GGEQEKMELF VNFCEDTIFE MQLASQISES
     DSADRPEEEE QAEEDSSYML EIEGEEEDDR SFESVSAFAM ACASVRRNVA NFLKRATLKN
     LRKQYRKVKK MTVKELVKVF FSFFWTLFVG LFQLFFTILG GIFQILWNTV FGGGLVEGAK
     NIRVTKILGD MPDPTQFGIH DDALEAERAE VTEPGIATEL VYFVKGEKGD ADIMSDLFGY
     HSKKESGLKH GPEVGLGDLS EIIGKDEPPT LESAVQKKRK AQAAEMKAAH EAEGKVESEK
     ADMEDGEKED TAKEEVQAEA LWAEATKKKK RRCGQKVEKP EAFMANFFKG LEIYQTKLLH
     YLARNFYNLR FLALFVAFAI NFILLFYKVT EEPLEEETED VANLWNSFND EEEEEAMVFF
     VLQESTGYMA PTLRALAIIH TIISLVCVVG YYCLKVPLVV FKREKEIARK LEFDGLYITE
     QPSEDDIKGQ WDRLVINTPS FPNNYWDKFV KRKVINKYGD LYGAERIAEL LGLDKSALDF
     SPVEETKAEA ASLVSWLSSI DMKYHIWKLG VVFTDNSFLY LAWYTTMSVL GHYNNFFFAA
     HLLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDDDE
     PDMKCDDMMT CYLFHMYVGV RAGGGIGDEI EDPAGDPYEM YRIVFDITFF FFVIVILLAI
     IQGLIIDAFG ELRDQQEQVR EDMETKCFIC GIGNDYFDTT PHGFETHTLQ EHNLANYLFF
     LMYLINKDET EHTGQESYVW KMYQERCWDF FPAGDCFRKQ YEDQLG
//
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