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Database: UniProt
Entry: F6TFD5_HORSE
LinkDB: F6TFD5_HORSE
Original site: F6TFD5_HORSE 
ID   F6TFD5_HORSE            Unreviewed;      4848 AA.
AC   F6TFD5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSECAP00000013158};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSECAP00000013158};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013158, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013158, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013158,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013158}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013158};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000013158}.
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DR   PaxDb; F6TFD5; -.
DR   Ensembl; ENSECAT00000016294; ENSECAP00000013158; ENSECAG00000013267.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000013267; -.
DR   ExpressionAtlas; F6TFD5; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4161   4185       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4389   4409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4457   4476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4588   4606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4649   4670       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4729   4752       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      568    779       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      995   1189       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1235   1447       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3896   3931       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4848 AA;  549479 MW;  96FBB07F97860EB4 CRC64;
     EDEVVLQCIA NVHKEQRKFC LAAEGLGNRL CFLEPTSEAK YVPPDLCVCN FVLEQSLSVR
     ALQEMLANTG ENGGEGAAQG GGHRTLLYGH AILLRHSFSG MYLTCLTTSR SQTDKLAFDV
     GLREHATGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVF SERYLHLSIS NGNIQVDASF
     MQTLWNVHPT CSGSSIEEGY LLGGHVVRLF HGHDECLTIP STDQNDSQHR RVFYEAGGAG
     TRARSLWRVE PLRISWSGSN IRWGQAFRLR HLTTGHYLAL TEDQGLILQD RGKSDTKSTA
     FSFRASKEIK EKLDSSHKRD IEGMGVPEIK YGDSVCFVQH VSSGLWVTYK AQDAKTSRLG
     PLKRKVILHQ EGHMDDGLTL QRCQQEESQA ARIIRNTTAL FSQFVSGNNR TTAPVTLPIE
     EVLQTLQDLI AYFQPPEEEM QHEDKQNKLR SLKNRQNLFK EEGMLALVLN CIDRLNIYNS
     VAHFAGIARE ESGMAWKEIL NLLYKLLAAL IRGNRNNCAQ FSNNLDWLIS KLDRLESSSG
     ILEVLHCILI ESPEALNLIA EGHIKSIISL LDKHGRNHKV LDVLCSLCLC NGVAVRANQN
     LICDNLLPRR NLLLQTRLIN DVTSIRPNIF LGVAEGSAQY KKWYFELIID QVDPFLTAEP
     THLRVGWASS SGYAPYPGGG EGWGGNGVGD DLYSYGFDGL HLWSGRIPRA VASINQHLLK
     SDDVVSCCLD LGVPSISFRI NGQPVQGMFE NFNTDGLFFP VVSFSAGVKV RFLMGGRHGE
     FKFLPPTGYA PCYEALLPKE KMRLEPVKEY KRDAEGVRDL LGTTQFLSQA SFIPCPIDTS
     QVVLPPHLEK IRDRLAENIH ELWGMNKIEL GWTFGKIRDD NKRQHPCLVE FSKLPETEKN
     YNLQMSTETL KTLLALGCHI AHVNPAAEED LKKVKLPKNY MMSNGYKPAP LDLSDVKLLP
     PQEILVDKLA ENAHNVWAKD RIKQGWTYGI QQDLKNKRNP RLVPYALLDE RTKKSNRDSL
     REAVRTFVGY GYNIEPSDQE LADPAVEKVS IDKIRFFRVE RSYAVRSGKW YFEFEVVTGG
     DMRVGWARPG CRPDVEGPMT KPLCLKAAGA SVGIKGVGIL DVWQPGDVVG CMINLDDASM
     IFTLNGELLI TNKGSELAFA DYEIENGFVP ICSLGLSQIG RMNLGMDAST FKFYTMCGLQ
     EGFEPFAVNM NRDVAMWFSK RLPTFVNVPK DHPHIEVVRI DGTMDSPPCL KVTHKTFGTQ
     NSNANMIYCR LSMPVECHAS FSHSPCLDSD AFQKRKQMQE ILSHTTTQCY YTIRIFAGQD
     PSCVWVGWVT PDYHLYSEKF DLNKNCTVTV TLGDERGRVH ESVKRSNCYM VWGGDIVATS
     QRSSRSNVDL EIGCLVDLAM GMLSFSANGR ELGTCYQVEP NTKVFPAVFL QPTSTALFQF
     ELGKLKNAMP LSAAIFKSEE KNPVPQCPPR LDIQTIQPVL WSRMPNSFLK VETERVSERH
     GWVVQCLEPL QMMALHIPEE NRCVDILELC EQEDLMLFHY HTLRLYSAVC ALGNSRVAYA
     LCSHVDLSQL FYAIDNKYLP GLLRSGFYDL LISIHLASAK ERKQMMKNEY IIPITSSTGK
     IRLYPDESKR HGLPGVGLRT CLKPGFRFST PCFVVTSEEH QKQSPEIPLE ILKTKALSML
     TEAVQCSGAH IRDPVGGSVE FQFVPVLKLI GTLLVMGVFD DDSVRQILLL IDPSVFGEHS
     GEMEEGAEKE EVTQVEEKAV EAGEKASKEA PVKGLLQTRL PESVKLQMCE LLSYLCDCEL
     QHRVEAIVAF GDIYVSKLQA NQKFRYNELM QALNMSAALT ARKTREFRSP PQEQINMLLN
     FQLGENCPCP EEIREELYDF HEDLLIHCGV PLEEEEEEEE DTSWTGKLRA LVYKIKGPPK
     PEKELPTEEE ERCPTTLKEL ISQTMIRWAQ EDQIQDAELV RMMFNLLRRQ YDSIGELLQA
     LRKTYTISQA SVSDTINLLA ALGQIRCLLS VRMGKEEELL MINGLGEIMN NKVFYQHPNL
     MRVLGMHETV MEVMVNVLGA EKSQIAFPKM VASCCRFLCY FCRISRQNQK AMFEHLSYLL
     ENSSVGLASP SMRGFTPLDV AASSVMDNNE LALGLEEPDL EKVVTYLAGC GLQSCPMLLA
     KGYPDVGWNP IEGERYLSFL RFAVFVNSES VEENASVVVK LLIRRPECFG PALRGEGGNG
     LLAAMQGAIK ISENPALDLP SQGYKREVTE DAEDDEIVHM GNAIMSFYSA LIDLLGRCAP
     EMHLIQTGKG EAIRIRSILR SLVPTEDLVG IISIPLKLPS LNKDGSVSEP DMAANFCPDH
     KAPMVLFLDR VYGIKDQTFL LHLLEVGFLP DLRASASLDT VSLSTTEAAL ALNRYLCSAV
     LPLLTRCAPL FAGTEHYTSL IDSTLQTIYR LSKGRSLTKA QRDTIEECLL AICNHLRPSM
     LQQLLRRLVF DVPQLNEYCK MPLKLLTNHY EQCWKYYCLP SGWGSYGLAV EEELHLTEKL
     FWGIFDSLSH KKYDQDLFRM ALPCLSAIAG ALPPDYLDTR ISATLEKQVS VDADGNFDPK
     PINTVNFSLP EKLEYIVTKY AEHSHDKWAC DKSMQRWKYG ISLDENVKTH PLIRPFTLTE
     KEKEIYRWPA RESLKTMLAV GWTIERTKEG EALVQQRENE KLRSVSQASQ GNSYSPAPLD
     LSNVVLSREL QGMVEVVAEN YHNIWAKKKK LELESKGGGS HPLLVPYDTL TAKEKFRDRE
     KAQDLFKFLQ VNGIVVSRGM KDMELDASSM EKRFAYKFLK KILKYVDSAQ EFIAHLEAIV
     SSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP LKPLSSSGYA SHKEKEMVAS
     LFCKLAALVR HRISLFGNDS TTMVSCLHIL AQTLDTRTVM KSGSELVKAG LRAFFENAAE
     DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT SIFEHVAQHQ FGVDLLLGDV
     QISCYHILCS LYSLGTGKNI YVERQRPALG ECLASLAAAI PVAFLEPTLN RYNPLSVFNT
     KTPRERSILG MPDTVEEMCP DVPQLEGLMK EINDLAESGA RYTEMPHVIE VILPMLCNYL
     SYWWERGPEH LPPSTGPWCT KVTSEHLSVT LGNILKIINN NLGIDEASWM KRIAVYAQPI
     ISKARPGLLR SHFLPTLEKL KKKAVKTVQE EEQLKADSKG DTQEAELLIL DEFAVLCRDL
     YAFYPMLIRY VDNNRSNWLK SPDAYSDQLF RMVAEIFILW CKSHNFKREE QNFVIQNEIN
     NLAFLTGDSK SKMSKAMQVK SGGQDQERKK TKRRGDLYSI QTSLIVAALK KMLPIGLNMC
     TPGDQELISL AKSRYSYKDT DEEVKEHLRN NLHLQEKSDD PAVKWQLNLY KDVLKSEEPS
     NPEKTVERVQ RISAAVFHLE QVEQPLRSKK AVWHKLLSKQ RKRAVVACFR MAPLYNLPHR
     SINLFLHGYQ RFWIETEEYS FEEKLVQDLA KSPKVEEEEE EETEKQPDPL HQIILHFSRN
     ALTERSKLED DPLYTSYSSM MAKSCQSGEE EEEEEDKEKT FEEKEMEKQK TLYQQARLHE
     RGAAEMVLQM ISASKGEMSP MVVETLKLGI AILNGGNAGV QQKMLDYLKE KKDAGFFQSL
     SGLMQSCSVL DLNAFERQNK AEGLGMVTEE GTLIVRERGE KILQNDEFTR DLFRFLQLLC
     EGHNSDFQNF LRTQMGNTTT VNVIISTVDY LLRLQESISD FYWYYSGKDI IDESGQHNFS
     KALAVTKQIF NSLTEYIQGP CIGNQQSLAH SRLWDAVVGF LHVFANMQMK LSQDSSQIEL
     LKELLDLLQD MVVMLLSLLE GNVVNGTIGK QMVDTLVESS TNVEMILKFF DMFLKLKDLT
     SSDTFKEYDP DGKGIISKKE FQKAMEGQKQ YIQSEIDFLL SCAEADENDM FNYIDFVDRF
     HEPAKDIGFN VAVLLTNLSE HMPNDSRLKS LLDPAESVLN YFEPYLGRIE IMGGAKKIER
     VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEQEKME LFVNFCEDTI FEMQLASQIS
     ESDSADRPEE EEQAEEDSSY MLEIEGEEED DRSFESVSAF AMACASVRRN VANFLKRATL
     KNLRKQYRKV KKMTVKELVK VFFSFFWTLF VGLFQLFFTI LGGIFQILWN TVFGGGLVEG
     AKNIRVTKIL GDMPDPTQFG IHDDALEAER AEVTEPGIAT ELVYFVKGEK GDADIMSDLF
     GYHSKKESGL KHGPEVGLGD LSEIIGKDEP PTLESAVQKK RKAQAAEMKA AHEAEGKVES
     EKADMEDGEK EDTAKEEVQA EALWAEATKK KKRRCGQKVE KPEAFMANFF KGLEIYQTKL
     LHYLARNFYN LRFLALFVAF AINFILLFYK VTEEPLEEET EDVANLWNSF NDEEEEEAMV
     FFVLQESTGY MAPTLRALAI IHTIISLVCV VGYYCLKVPL VVFKREKEIA RKLEFDGLYI
     TEQPSEDDIK GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA ELLGLDKSAL
     DFSPVEETKA EAASLVSWLS SIDMKYHIWK LGVVFTDNSF LYLAWYTTMS VLGHYNNFFF
     AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDD
     DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD EIEDPAGDPY EMYRIVFDIT FFFFVIVILL
     AIIQGLIIDA FGELRDQQEQ VREDMETKCF ICGIGNDYFD TTPHGFETHT LQEHNLANYL
     FFLMYLINKD ETEHTGQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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