ID F6TG92_XENTR Unreviewed; 1143 AA.
AC F6TG92;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Evolutionarily conserved-signaling intermediate in Toll pathway, mitochondrial {ECO:0000313|Ensembl:ENSXETP00000036500};
GN Name=ecsit {ECO:0000313|Ensembl:ENSXETP00000036500};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000036500};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000036500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000036500};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000036500}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
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DR AlphaFoldDB; F6TG92; -.
DR Ensembl; ENSXETT00000036500; ENSXETP00000036500; ENSXETG00000016738.
DR AGR; Xenbase:XB-GENE-853811; -.
DR Xenbase; XB-GENE-853811; ecsit.
DR HOGENOM; CLU_046917_0_0_1; -.
DR TreeFam; TF314943; -.
DR Bgee; ENSXETG00000016738; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR ExpressionAtlas; F6TG92; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0001764; P:neuron migration; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR040685; Annexin-like.
DR InterPro; IPR045575; ASTN_1_2_N.
DR InterPro; IPR026995; Astrotactin.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR16592; -; 1.
DR PANTHER; PTHR16592:SF8; ASTROTACTIN-1; 1.
DR Pfam; PF18411; Annexin_2; 1.
DR Pfam; PF19441; ASTN_1_2_N; 2.
DR SMART; SM00457; MACPF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1143
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169450"
FT TRANSMEM 148..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 757..938
FT /note="MACPF"
FT /evidence="ECO:0000259|SMART:SM00457"
SQ SEQUENCE 1143 AA; 128099 MW; 60A6C169EA3E215D CRC64;
MAPAGAFWML LTGYLLISRS SGEEDSSREM ECKMKSITVS ALPFLRENDL SIMHSPSASE
PKLLFSVRND FPGEIAVADD LENTELPYFV LEIAGNTDDI PLVRWRQQWL ENGTLLFHIH
HQDGSSSLPG QETTEEPQGE AAEEELRILH ISVMGGMIAL LLCILCLLLI LYTRRRWCKR
RRAPQPQKSA SAEAANEIHY IPSVLIGGGH GRESLRNARG QSTHPGGTLS IRETPILDGY
EYDVTELRHH LQRECMNGGE DFSSQVSRTL DSLHGCNEKN TMDLTPGMYS ASYITFLNPE
GDCGADLDNE TQLTFYTDPS RSRRRSRVGS PRSPVNKMTL TLISVTSCVI GLVCSSQLSC
PLIVKITLHV PEHLIADGSR FILLEGSQLD ASDWLNPAQV VLFSQMNSSG PWALDLCARR
ILDPCEHLCD SDTGECLCHE GYMRDPVHKH LCIRNEWGTN QGPWPYTMFQ RGFDLVLGEQ
PSDKIFRFTY TLGEGMWLPL SKSFVIPPAE LAINPSAKCK TDMTVMEDAV EVREELMTSS
SFDNLEILLD SFGPVRDCSK DNGGCTKNFR CVSDRKLDSS GCVCPSGLSP MKDLSGCYDR
QMGVDCSDGF NGGCEQLCLH EDVPLSEESD LYNIYMYCGC IEEYKLGVDG LACHLITEPC
PGGEHCGDNQ EVPMNQTLFG ELFYGYNNLT KELAPNQLLK GTFRQNNFAR GLEHQLPDGL
LVATIPSETQ CHEEISEPVP DPEFLTGMVN FSEVSGYPLI QHWTVRSVIY HVRLNQPSLS
QAFSQALHSL DGATSRLEFM ALLKQFGNHY IQEAVYGFEE SCSIWYPNRQ VQRQLWLEFE
DISKERDPKV LTFPEYITSL LDTGTRRMAH GVRMECQSRG RCSSYCPLCH VTSSPDAPPE
PVLLEVTKAI PIYELVTSNN ATQQVSAVAF IAVLSSIWCS GHGDVIEDWC RCDSTAFGVD
GLPNCAPLPQ PLYSNMDNTG RRSEPSHVTV KMPCPEVDDV KSQEVADKIY NLFNGYTSGK
EQQTAYNTLL ELGSPTLHRV RYHYNQHFQS FGEFTWRCED ELGPRKAGLV LSQLDSLSPW
CSHLLSGPRI TLRRSSIHYL ACRYSEVKPH ALNWLELSRD LRKNCEEQVM NQTEESNDTG
RHL
//
