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Database: UniProt
Entry: F6TI15_HORSE
LinkDB: F6TI15_HORSE
Original site: F6TI15_HORSE 
ID   F6TI15_HORSE            Unreviewed;       693 AA.
AC   F6TI15;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   24-JAN-2024, entry version 55.
DE   SubName: Full=Nephrocystin 1 {ECO:0000313|Ensembl:ENSECAP00000018496.2};
GN   Name=NPHP1 {ECO:0000313|Ensembl:ENSECAP00000018496.2,
GN   ECO:0000313|VGNC:VGNC:20836};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018496.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000018496.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018496.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000018496.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018496.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   AlphaFoldDB; F6TI15; -.
DR   Ensembl; ENSECAT00000022383.4; ENSECAP00000018496.2; ENSECAG00000020702.4.
DR   VGNC; VGNC:20836; NPHP1.
DR   GeneTree; ENSGT00390000007701; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   Bgee; ENSECAG00000020702; Expressed in epithelium of bronchus and 23 other cell types or tissues.
DR   ExpressionAtlas; F6TI15; baseline.
DR   GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR   GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR   GO; GO:1903348; P:positive regulation of bicellular tight junction assembly; IEA:Ensembl.
DR   CDD; cd11770; SH3_Nephrocystin; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR039687; NPHP1.
DR   InterPro; IPR030642; NPHP1_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15176; NEPHROCYSTIN; 1.
DR   PANTHER; PTHR15176:SF1; NEPHROCYSTIN-1; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          163..223
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          63..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          110..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..155
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  78433 MW;  AFEBDDDCA8517508 CRC64;
     MLARRPRDPL QALQRRSQEL KQQVDSLLSE SRLKGALESS RRRDIYQRCI QLKQAIDENK
     NTLQKLNKAD EPAPVGNYDQ KKKEEHSLLD KLTHQLQELA VSLRREDVTE IGALTEREED
     EDSAEEDEEE EEDEEESEES GEEEEGTEEE EEEKQENESH QQATSKEYVA IGDFTAQQVG
     DLTFKKGEIL RIIEGKPDGW WTAKNAKGEK GLVPRTYLEP YNKDKGEESS EEGSEEDAEV
     GDETAEGAEV KQRADSHWSA VQKAVSEQIN TVDVLTTMGA IPAGFRPSTL FQLLEEGNQF
     RASYFLQPEL TPSQLAFRDL MWDAKMGTIR SRPSRVSLIL TLWSCKMIPL PGMSIQVLSR
     HVRLCLFDGN KVLSNIHTVR ATWQPKKPKT WTFSPQVTGI LPCLLDGDCF IRSNSSSPDL
     GILFELGISY IRNNFLVLKS TGERGELSCG WVFLKLFDAS GIPIPAKTYE LFLNGGTPYE
     KGVEVDPSVS RRAHGSVFYQ MMIMRRQPQL LVKLRSLNRR SRNILSLLPE TLIGSMCSIH
     LLIFYRQILG DVLLKDRTSM QSADLMSNPV LATFPKLLEQ PDVMDALRSS WAEKESTLKR
     SEKRVKELLK AAFVLVYHDC ALPLLQSTLL PPFRWAEGEA EAARWKVIAD FLTETRENGG
     ALHALLSPDG LHEPFDVSEQ TYDFLGEIRK NAA
//
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