ID F6TI15_HORSE Unreviewed; 693 AA.
AC F6TI15;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Nephrocystin 1 {ECO:0000313|Ensembl:ENSECAP00000018496.2};
GN Name=NPHP1 {ECO:0000313|Ensembl:ENSECAP00000018496.2,
GN ECO:0000313|VGNC:VGNC:20836};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018496.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018496.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018496.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018496.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018496.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6TI15; -.
DR Ensembl; ENSECAT00000022383.4; ENSECAP00000018496.2; ENSECAG00000020702.4.
DR VGNC; VGNC:20836; NPHP1.
DR GeneTree; ENSGT00390000007701; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000020702; Expressed in epithelium of bronchus and 23 other cell types or tissues.
DR ExpressionAtlas; F6TI15; baseline.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR GO; GO:1903348; P:positive regulation of bicellular tight junction assembly; IEA:Ensembl.
DR CDD; cd11770; SH3_Nephrocystin; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR039687; NPHP1.
DR InterPro; IPR030642; NPHP1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15176; NEPHROCYSTIN; 1.
DR PANTHER; PTHR15176:SF1; NEPHROCYSTIN-1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 163..223
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 63..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..155
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 78433 MW; AFEBDDDCA8517508 CRC64;
MLARRPRDPL QALQRRSQEL KQQVDSLLSE SRLKGALESS RRRDIYQRCI QLKQAIDENK
NTLQKLNKAD EPAPVGNYDQ KKKEEHSLLD KLTHQLQELA VSLRREDVTE IGALTEREED
EDSAEEDEEE EEDEEESEES GEEEEGTEEE EEEKQENESH QQATSKEYVA IGDFTAQQVG
DLTFKKGEIL RIIEGKPDGW WTAKNAKGEK GLVPRTYLEP YNKDKGEESS EEGSEEDAEV
GDETAEGAEV KQRADSHWSA VQKAVSEQIN TVDVLTTMGA IPAGFRPSTL FQLLEEGNQF
RASYFLQPEL TPSQLAFRDL MWDAKMGTIR SRPSRVSLIL TLWSCKMIPL PGMSIQVLSR
HVRLCLFDGN KVLSNIHTVR ATWQPKKPKT WTFSPQVTGI LPCLLDGDCF IRSNSSSPDL
GILFELGISY IRNNFLVLKS TGERGELSCG WVFLKLFDAS GIPIPAKTYE LFLNGGTPYE
KGVEVDPSVS RRAHGSVFYQ MMIMRRQPQL LVKLRSLNRR SRNILSLLPE TLIGSMCSIH
LLIFYRQILG DVLLKDRTSM QSADLMSNPV LATFPKLLEQ PDVMDALRSS WAEKESTLKR
SEKRVKELLK AAFVLVYHDC ALPLLQSTLL PPFRWAEGEA EAARWKVIAD FLTETRENGG
ALHALLSPDG LHEPFDVSEQ TYDFLGEIRK NAA
//