ID F6TLB6_CIOIN Unreviewed; 891 AA.
AC F6TLB6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000007196.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000007196.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6TLB6; -.
DR STRING; 7719.ENSCINP00000007196; -.
DR Ensembl; ENSCINT00000007196.3; ENSCINP00000007196.3; ENSCING00000003511.3.
DR GeneTree; ENSGT00550000074797; -.
DR HOGENOM; CLU_324314_0_0_1; -.
DR InParanoid; F6TLB6; -.
DR Proteomes; UP000008144; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 211..405
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 536..694
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
SQ SEQUENCE 891 AA; 101913 MW; E23D9FD891B9986A CRC64;
VMERKDDLFF LFEIKFRNKL VEHVTDWLMC SAIQTVDIDK HVLRELDQCA VIAVGVLLKG
LPLHPDEGDG GDVPEAKSQL FLKYFTLFMK LLGECSDKLA ESELLDESAS EDTVTLRRLI
IVAMSNLLSA NIESGLVHAM SLAYHDEVQT RSAFLEVLTK IVQQGSDGFQ TLGDSVSTER
FERLVELVTM MGDNGELPIA NALANVVHTS YMDELARVFV TLFDAKHLLY QLLWNMFTKE
VEEADSVQTL FRGNSLASKI MTFCFKVYGA SYLHNLVEPL VAWSLTQDIV NLHFEVDQKR
IPPGYDILQC RANLQRLTER FFTRIMTSTD KFPPQLKSVC HCLYQVVSQR FHESGTGAVA
SAIFLRFLNP AIATPYEYGL SDRRLPPNLA RAFKFMCKIM QNIANHVVFT KEEHMKHFNE
FVSARFDVCQ QFFMQISTPE CASVESSGQS TSFMNDTNVS ALHRLLWNDQ EKIGRYLAKS
RNAKAVGRRP FDKMVTLLAY IGPPEYTRPV LETRMTGQNI LPCKFEELMT KRKAADSEEY
KLVKGLNIFY QFGRSKMGYP VFYYVARRYV LHNIREDILM FYILQALKPY SARKFDIIID
LTHVGAKNRF RGQYLPKWLV LYPQQIYKNL DTVYVYNPNT WVRDYVSYNE GSFNQVEGHR
SIHFIEDLLE LKKFIELDHQ KVPSATRGLG EDVTVYHNAW RLGQIHNKVH VKVGSKAVQL
TMVDKTKLLG YDVVLNDIYY AHEIEAIHFT EATNTFSLKV STNNNAVMSF THPDAAKIVE
GIRYIRNRWE ISQPQQMVSH HKIEAKDVPG TLLNMALLNL GCSKPLVRSS AYNLLCVLTT
AFNLQLEGRL CESDGLCIPT NNALFIISIS NTLARNENHL TLEFLEECIT G
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