GenomeNet

Database: UniProt
Entry: F6TN69_MONDO
LinkDB: F6TN69_MONDO
Original site: F6TN69_MONDO 
ID   F6TN69_MONDO            Unreviewed;      4864 AA.
AC   F6TN69;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   22-NOV-2017, entry version 43.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMODP00000002002};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSMODP00000002002};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000002002, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000002002, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000002002}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000002002}.
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DR   STRING; 13616.ENSMODP00000002002; -.
DR   Ensembl; ENSMODT00000002044; ENSMODP00000002002; ENSMODG00000001626.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F6TN69; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   Bgee; ENSMODG00000001626; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4177   4201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4405   4425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4473   4492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4604   4622       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4665   4686       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4745   4768       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       96    151       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      158    203       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    329       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      339    396       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      581    792       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1008   1204       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1250   1462       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3920   3948       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3587   3609       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4864 AA;  553142 MW;  E39D1F53139F7E67 CRC64;
     GGGGEKKKVD YRNEDEVVLQ CVANIHKEQR KFCLAAEGLG NRLCFLEPTS EAKYVPPDLC
     ICNFVLEQSL SVRALQEMLA NTGENANEGV AQGGGHRTLL YGHAILLRHS FSRMYLTCLT
     TSRSQTDKLA FDVGLQEHAT GEACWWTIHP ASKQRSEGEK VRIGDDLILV SVSSERYLHL
     SISNGNIQVD ASFMQTLWNV HPTCSGSSIE EGYLLGGHVV RFFHGHDECL TTQSTDQNDS
     QHRRIFYETG GAGSRARSLW RVEPLRISWS GSNIRWGQAF RLRHITTGQY LALTEDQGLI
     LQDRGKSDTK STAFCFRASK EIKEKLDSSH KRDIEGMGIA EIKYGDSICF VQHVASGLWM
     TYKAQDAKTS RLGPLKRKVI LHQEGHMDDG LTLQRCQHEE SQAARIIRNT TSLFSQFISG
     NNRTAAPITL PIEEVLQTLK DLITYFQPPE EEMQHEDKQN KLRSLKNRQN LFKEEGMLAL
     VLNCIDRLNV YNSVAHFTGF AREESGTAWK EILNLLYQLL AALIRGNRNN CAQFSNNLDW
     LISKLDRLES SSGILEVLHC ILIESPEALN LISEGHIKSI ISLLDKHGRN HKVLDVLCSL
     CLCNGVAVRA NQNLICDNLL PRRDLLLQTR LINDVTSIRP NIFLGVAEGS AQYRRWYFEL
     IIDQVDPFLT AEPTHLRVGW ASSPGYAPYP GGGEGWGGNG VGDDLYSYGF DGLHLWSGRI
     PRAVASVNQH LLKSDDVVSC CLDLGVPSIS FRINGQPVQG MFENFSTDGL FFPVVSFSAG
     IKVRFLLGGR HGEFKFLPPS GYAPCYEALL PKEKMILESV KEYKRDTEGI RDLLGTTRFL
     SQASFIPCPI DTSQIVLPPH LEKIRDRLAE NIHELWGMNK IELGWTFGKI RDDNKRQHPC
     LVEFSKLPET EKNYNLQMST ETLKTLLALG CHIVHINLAA EEDLKKAKLP KNYMMSNGYK
     PSPLDLSDVK LLPPQEILVD KLAENAHNVW AKDRIKQGWT YGIQQDLKNK RNPRLVPYAL
     LDERTKKSNR DSLREAVRTF IGYGYNVEPS DQELADQTME KVSVDKIRFF RVEQSYAVKS
     GKWYFEFEVV TGGDMRVGWA RPGCRPDIEL GADNQAFVFE GSKGQRWHQG SGYFGRNWQS
     GDVVGCMINL DDASMIFTLN GELLITNKGS ELAFADYEIE NGFVPICSLG LSQIGRMNLG
     MDASTFKYYT MCGLQEGFEP FAVNMNRDVA MWFSKRLPTF VNVPKDHTHI EVTRIDGTID
     APPCLKVTHK TFGTQNSSAD MIYCRLSMPV ECYSSFHHST GLESDIFQKR KQMQEIVAHT
     TTQCYYSVRI FAGQDPSYTW IGWVTPDYHL YSEKFDLNKN CTVTVTLGDE RGRVHESVKR
     SNCYMIWGGD IIANSQRSSR SNVDLEIGCL IDLATGMISF SANGKELDTC YQVEPNTKVF
     PAVFLQPTST SLVQFELGKL KNAMPLSAAI FKSEEKNLVP QCPPRLDVQT IQPVLWSRMP
     NSFLKIEMER VSERHGWMVQ CLEPLQMMAL HIPEENRCVD ILELCEQEDL MRFHYHTLKL
     YSAVCALGNN RVAYALCSHV DLSQLFYTID NQYLPGLLRC GFYDLLISIH LAHAKEGKLM
     MKNEFIIPIT NTTRKIRLYP DESKRHGLPG VGLSTCLKPG FNFSTPCFIV TSEERQKLSP
     EIPLEILKTK ALSMLTEAVQ CSGAHIRDPV GGSVEFQFVP VLKLIGTLLV MGVFDNDDVR
     QILLLIDPTV FGEHKDEAQE STEKEVTHVE EKAVEAGEKS SKNTQAPVRG LLQTRLPESV
     KLQMCELLNY FCDCELQHRV EAIVAFGDIY VSKLQANQKF RYNELMQALN MSAALTAKKT
     REFRSPPQEQ INMLLNFQMG ENCPCPEEIR EELYDFHDDL LIHCGIPLEE EEEEEEDISW
     TGKLRALIYK IKGPPKPEKE QPMEEEEKCP TTLKELISQT MVCWAQEDQI QNPELVRIMF
     NLLRRQYDSI GELLQAMRKT YTISHASVED TINLLAALGQ IRSLLSVRMG KEEELLMING
     LGDIMNNKVF YQHPNLMRVL GMHETVMEVM VNVLGGEKSQ IAFPKMVASC CRFLCYFCRI
     SRQNQKAMFE HLSYLLENSS VGLASPAMRG STPLDVAASS VMDNNELALG LEEPDLEKVV
     TYLAGCGLQS CPMLLARGYP DIGWNPIEGE RYLSFLRFAV FVNSESVEEN ASVVVKLLIR
     RPECFGPALR GEGGNGLLAA MQGAIKISEN PTLDLPSQGY KREISSEEDD SEEEIVHMGN
     SIMSFYSALI DLLGRCAPEM HLIQTGKGEA IRIRSILRSL VPTEDLVGII SIALKLPTLN
     KDGSVNEPDM AANFCPDHKA PMVLFLDRVY GIEDQTFLLH LLEVGFLPDL RASASLDTVS
     LSTTEAALAL NRYLCSAVLP LLTRHAPLFA GTEHYTSLID STLQTIYRLS KGRSLTKAQR
     DTIEECLLAI CNHLRPSMLQ QLLRRLVFDV PLLNEYCKMP LKLLTNHYEQ CWKYYCLPSG
     WGSYGLAVEE ELHLTEKLFW GIFDSLSHKK YDAELFRMAL PCLSAIAGAL PPDYLDTRIT
     ATLEKQTSVD AEGNFDPKPI NTINYSLPEK LEYVVTKYAE HSHDKWACDK SQNGWKYGIS
     LDENVKTHPL IRPFKTLTEK EKEIYRWPAR ESLKTMLAVG WTVERTRESE AIIQQRENEK
     LRSISQTSQG NSYNPAPLDL SNVVLSREVQ GMVEVVAENY HNIWAKKKKM ELESKGGGSH
     PLLVPYDTLT AKEKFRDREK SQELFKFLQV NGIVVSRDLK DMELDTSSME KRFAYKFLKK
     ILKYVDSAQE FIAHLEAIVS SGKTEKSPHD QEIKFFAKVL LPLVDQYFTN HCLYFLSSPL
     KPLSSSGYAS NKEKEMVASL FCKLAALVRH RISLFGSDST TMVSCLHILA QTLDTRTVMK
     SGSELVKAGL RAFFENAAED LEKTSENLKL GKFTHSRTQI KGVSQNINYT TVALLPILTS
     IYEHVAQHQF GVDLLLSDVQ ISCYHILCSL YSLGTGKNIY VERQRPALGE CLASLAAAMP
     VAFLEPSLNC YNSLSVFNTK TPRERSILGM PDTVEEMCLD IPQLEGLMKE IYDLAESGAR
     YTEMPHVIEV ILPMLCNYLS YWWEQGPENL PPSAGPCCTL VTSEHLSIIL GNILKIINNN
     LGIDEASWMK RIAVYAQPII SKARSDLLKS HFIPTLEKLK KKAVKIVLEE EQLKADSKGD
     TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRSNWLKN PDADSDELFR MVAEVFILWC
     KSHNFKREEQ NFVIQNEINN LAFLTGDSKS KMSKGINFSG GQDQERKKTK RRGDLYSIQT
     SLIVAALKKM LPIGLNMCTP GDQELISLAK IRYGYRDTDE EVKDHLRNNL HLQEKSDDPA
     VKWQLNLYKD VLKNEEPCDP EKTVERVQRI SAAVFHLEQV EQPLRSKKAV WHKLLSKQRK
     RAVVACFRMA PLYNLPHRSI NLFLHGYQRF WIETEEYSFE EKLVQDLAKP PKVEEEEEED
     AENQPDPLHQ IILHFSRNAL TERSHLEDDP LYTAYSGMMA KSCQSGEEEE EEEKEKTFEE
     KEMEKQKTLY QQARLHDRGA AEMVLQMISA SKGEMGPMVV ETLKLGIAIL NGGNPGVQQK
     MLDYLKEKKD AGFFQSLSGL MQSCSVLDLN AFERQNKAEG LGMVTEEGTL IVRERGEKVL
     QNHEFTCDLF RFLQLLCEGH NSDFQNFLRT QMGNTTTVNI IISTVDYLLR LQESISDFYW
     YYSGKDIIDE SGQRNFSKAL AVTKQIFNSL TEYIQGPCIG NQQSLAHSRL WDAVVGFLHV
     FANMQMKLSQ DSSQIELLKE LLDLLQDMVV MLLSLLEGNV VNGTIGKQMV DTLVESSTNV
     EMILKFFDMF LKLKDLTNSD AFKEYDPDGK GIISKKEFQK AMEGQKQYPQ SEIEFLLSCA
     EADENDMFNY VDFVDRFHEP AKDIGFNVAV LLTNLSEHMP NDSRLQCLLD PAESVLNYFE
     PYLGRIEIMG GAKKIERVYF EISESSRTQW EKPQVKESKR QFIFDVVNEG GEQEKMELFV
     NFCEDTIFEM QLASQISESD SAERLEEEED EEEFSCVVEA EEDEEENKSL ESASAFATAC
     VSIKKNVASF LKMVSLRNLR KQYRKVKKMT VKELVKVFFS FFWMFFVGLF QLFFTVVWGI
     FQILWNTVFG GGLVEGAKNI RVTKILGDMP DPTQFGIHDD VLEAERAEVT EQNVTAELVH
     FVKGEKGEAD IMSDLFGLHT KKEGNTKHGP DPGLGDLSEI IGNDGPLTLE STVQKKRKAQ
     AAEMKRESER EGKMESEKAD MEDGEKQDKI KEEEQQEENL DGERTKKKRR HGQREERPEA
     FMANFFKGLE IYQTKMLHYL ARNFYNLRFL ALFVAFAINF ILLFYKVTEE PFEDDAENSN
     LWTPFKEEEE EEEGMVFFVL QESTGYMAPT LRALAIIHTI ISFVCVVGYY CLKVPLVVFK
     REKEIARKLE FDGLYITGQP SEDDIKGQWD RLVINTPSFP SNYWDKFVKR KVINKYGDLY
     GAERIAELLG LDKNALDFSP VEQTEPEEAS LVSWLSSIDM KYHIWKLGVV FTDNSFLYLA
     WYTTMSILGH YNNFFFAAHL LDIAMGFKTL RTILSSVTHN GKQLVLTVGL LAVVVYLYTV
     VAFNFFRKFY NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA GGGIGDEIED PAGDPYEIYR
     IVFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVRED METKCFICGI GNDYFDTTPH
     GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESYVWKM YQERCWDFFP AGDCFRKQYE
     DQLG
//
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