ID F6U0H3_XENTR Unreviewed; 2347 AA.
AC F6U0H3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Calcium channel, voltage-dependent, T type, alpha 1H subunit {ECO:0000313|Ensembl:ENSXETP00000052817};
GN Name=cacna1h {ECO:0000313|Ensembl:ENSXETP00000052817};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000052817};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000052817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000052817};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000052817}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8364.ENSXETP00000052817; -.
DR PaxDb; 8364-ENSXETP00000051094; -.
DR Ensembl; ENSXETT00000052817; ENSXETP00000052817; ENSXETG00000022646.
DR AGR; Xenbase:XB-GENE-6042121; -.
DR Xenbase; XB-GENE-6042121; cacna1h.
DR eggNOG; KOG2302; Eukaryota.
DR HOGENOM; CLU_000540_2_0_1; -.
DR InParanoid; F6U0H3; -.
DR TreeFam; TF313555; -.
DR Reactome; R-XTR-445355; Smooth Muscle Contraction.
DR Bgee; ENSXETG00000022646; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF192; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2347
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169485"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 723..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 858..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1179..1197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1217..1238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1250..1276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1314..1336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1416..1439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1495..1512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1532..1551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1615..1642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1717..1738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..311
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 659..889
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1177..1449
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1495..1748
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 364..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1895..1963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2041..2112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2201..2236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1448..1475
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 367..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1895..1942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2041..2064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2080..2112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2220..2236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2347 AA; 264220 MW; AFCFD6E77C0E2D1F CRC64;
MLVILLNCVT LGMFQPCEDT NCMSERCNIL EAFDGFIFAF FAVEMVIKMV ALGIFGQKCY
LGDTWNWLDF FIVMAGMLEY SLDGHNVSLS AIRTVRVLRP LRAINRVPSM RILVTLLLDT
LPMLGNVLLL CFFVFFIFGI VGVQLWAGLL RNRCFMDTNF VMSYNFTPLR PYYQVDDAED
NPYICSSNRD NGMLKCQDIP PKMDCSHVYY SDFPSRNSCV NINQYYNVCK PGEFNPHKGA
INFDNIGYAW IAIFQVITLE GWVDIMYYVM DAHSFYNFIY FILLIIVGSF FMINLCLVVI
ATQFSETKQR ENQLMQEQRA RYLSNDSTIA SFSEPGSCYE ELLKYICHIF RKVKRRTLRL
YNNWQNKRRK KVQPNSNTNS QGRHRKCKRR ITSIHHLIHH HHHHHHHHYH ISNGSPRGPR
SSPEICDVEM KIMKPKNQLR LPPASPSLQS MSPNSEAVHS IYHADCHLEA PQRKSSKSSN
ASSNIKLNAG LNHSNMNYPT IMPSQANKTS PATLPKGKRN GSNAVSLLSS PVSMKADSFG
KTNHLVGEHG LCRSSSKLSG LSVPCSLPSP QPSPLLCEIQ NCPYCANLLE NPDLELSDSE
SCESDSNGVY EFTQDLRRGD QRDQVQKGRK LKTKPKEANK VYLLWEEFTV RLKRIVDSKY
FNRGIMIAIL INTLSMGIEY HEQPEELTNA LEISNIVFTS MFALEMLLKL LAFGIFQYIK
NPYNIFDGII VVISVWEIIG QSDGGLSVLR TFRLLRVLKL VRFMPALRRQ LVVLVKTMDN
VATFCMLLML FIFIFSILGM HLFGCKFTWT ADTGETVKDR KNFDSLLWAI VTVFQILTQE
DWNMVLYNGM ASTSSWAALY FVALMTFGNY VLFNLLVAIL VEGFQAEGDA TRSDTEEDKA
SGNFDEDLEK LKELRAAELK MYSLAVTPNG HLDPRSSMPP PIIMRTAATP MPTPKSSPCM
DSSHPFGDSR RESSVSIDPS IVDQKSLASL RSTPCTPWGT YSNWGSRRSS WNSLGRAPSI
KKKSQSGERE SLLSGEGKGS TDDDSDDCKS SPAARVSLHR RAGSLDTRGS LDIPDFLQVP
TLRHSLSVSP LAMVPSDYQD CNGKMMHVPS DLFVRVEKHR EDPLEYEDDI EDSYCFRIRK
MLEPYKPTWC KTHEDWSLYM FSPQNQFRMM CQKVIAHKMF DHVVLVFIFL NCITIALERP
DIDPNSLERI FLSVSNYIFT AIFVLEMAIK VVALGFVSGE NTYLQSSWNV LDGILVFVSI
IDIVVSLASA GGAKILGVLR VLRLLRTLRP LRVISRAPGL KLVVETLISS LRPIGNIVLI
CCAFFIIFGI LGVQLFKGKF YYCEGLETRN ITNRSECTRA RYKWVRRKYN FDNLGQALMS
LFVLSSKDGW VNIMYDGLDA VATDVQPVKN HNPWMLLYFI SFLLIVSFFV LNMFVGVVVE
NFHKCRQHQE AEEARRREEK RLRRLEKKRR KAQRRPYYAE YSPARLYIHT MCTSHYLDLF
ITCIICINVI TMSMEHYNQP KSLDEALKYC NYVFTIVFVF EALFKLVAFG FRRFFKDRWN
QLDLAIVLLS IMGITLEEIE INASLPINPT IIRIMRVLRI ARVLKLLKMA TGMRALLDTV
VQALPQVGNL GLLFMLLFFI YAALGVELFG KLVCNEENPC EGLSRHATFE NFGMAFLTLF
RVSTGDNWNG IMKDTLRECN SDDKNCLTYL PVISPVYFVT FVLIAQFVLV NVVVAVLMKH
LEESNKEAKE DAEMDAEIEM EMSRALTPIS GGCTPASDGK GTEGGQDPLK GELLKQVGGA
VCQENVTLVI PESMEGAALL NDAVPACSIY QQQALPLPLQ PCVLGHEDGD FQRRDGSGSR
NLLAVKKISV SRMLSLPNDS YMFRPVLPAK SSYPLQEVET TEDNSPHGST ASLHSQPGDN
NSLLNIPVEC QPQASVSNHQ DSADLPKIPP PHTSSRSPSL NRSLRRQEAI RMDSVDQGGD
SKDLNVESTE SLHLGAPSVT TLVPNLLCTL NVSLQGTPQS SPRLSPQPRH SSVLTHNHVY
SQHSIPSRPS SVSSGNSNPE ESMFESSDLA DEEVSHINSS AKDWRGSSNN RSHSVSPFIS
QSSSPPPLSP SLKNCNSTVS LAGSSGKDKD LKKFYSVDTQ GFLAKPCWGD DQRRHSIEIC
PSIDDGDSCF DLSMEDKHCS SVLIRSDPEY INGVRRKKKM SPPCISIDPP MEDEGGTASR
TKASENSMML RRRTPSCEST AYRDSLDLSD NQLGDQISKT DRRTQVPCRN EHLIIPSYSF
DKVDGNGFSD LISNSGGSTP TSVFNEPVSL EMKQKDHNDL SGVSKVSLKT ALDHVSNPTE
DIIDNPL
//
