ID   F6U6P7_HORSE            Unreviewed;       934 AA.
AC   F6U6P7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Protein phosphatase 4 regulatory subunit 1 {ECO:0000313|Ensembl:ENSECAP00000020701.3};
GN   Name=PPP4R1 {ECO:0000313|Ensembl:ENSECAP00000020701.3,
GN   ECO:0000313|VGNC:VGNC:21789};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020701.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000020701.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020701.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000020701.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020701.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F6U6P7; -.
DR   Ensembl; ENSECAT00000024896.4; ENSECAP00000020701.3; ENSECAG00000023070.4.
DR   VGNC; VGNC:21789; PPP4R1.
DR   GeneTree; ENSGT00950000183066; -.
DR   HOGENOM; CLU_009128_1_1_1; -.
DR   TreeFam; TF105560; -.
DR   Proteomes; UP000002281; Chromosome 8.
DR   Bgee; ENSECAG00000023070; Expressed in testis and 23 other cell types or tissues.
DR   ExpressionAtlas; F6U6P7; baseline.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10648:SF8; SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          117..155
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          158..197
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REGION          311..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          458..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..349
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..416
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   934 AA;  104746 MW;  E22E56D1723312FC CRC64;
     MAVGVDDYSS ESDVIIIPSA LDFVSQDEML TPLGRLDKYA ASENVFNRQM VARSLLDTLR
     EVCDDERDCI AVLERISRLA DDSEPTVRAE LMEQVPHIAL FCQENRPSIP YAFSKYLLPI
     VVRYLADQNN QVRKTSQAAL LALLEQELIE RFDVETKVCP VLIELTAPDS NDDVKTEAVA
     IMCKMAPMVG KDITERLILP RFCEMCCDCR MFHVRKVCAA NFGDICSVVG QQATEEMLLP
     RFFQLCSDNV WGVRKACAEC FMAVSCATCQ EIRRTKLSAL FINLISDPSR WVRQAAFQSL
     GPFISTFANP SSSGQYFKEE SKSSEDTSVE DKNRIRDQEV PEDILIRPED VTADPSTSNS
     SVKLESTMED DAETSSKSPG EISVSVDSSL LCTLSSESHQ EAASNENDKK PGNHKSTLRP
     EVGTSSQDSA LLDQELYNSF HFWRTPLPEI DLDVELEQGS EDKFSPETAE AAPEVPTPGS
     PSITMATRKE LEEMIENLEP HIDDPDVKAQ VDVLSAALRA SSLDAPEEAS STEQRSDAQD
     ALGVSELANC RRSPDASVPF ASSAVENMDS TLRYIHNDSD LSTNSSFSPD EERRSKVQDV
     VPQALLDQYL SMTDPSRAQT VDTEIAKHCA YSLPGVALTL GRRNWHCLRE TYETLASDMQ
     WKVRRTLAFS IHELAVILGD QLTAADLVPI FNGFLKDLDE VRIGVLKHLH DFLKLLHIDK
     RREYLYQLQE FLVTDNSRNW RFRAELAEQL ILLLELYSPR DVYDYLRPIA LNLCADKVSS
     VRWISYKLVS EMVKKLHMAT PPTFGVDLIN ELVESFGRCP KWSGRQAFVF VCQTVIEDEC
     LPMDQFAVHL MPHLLTLAND RVPNVRVLLA KTLRQTLLEK DCFLTSASCH QEAVEQAIMA
     LQMDRDSDVK YFASIHPAST KISEDAMSTA SSTY
//