ID F6U8I4_HORSE Unreviewed; 1566 AA.
AC F6U8I4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Plexin C1 {ECO:0000313|Ensembl:ENSECAP00000020497.4};
GN Name=PLXNC1 {ECO:0000313|Ensembl:ENSECAP00000020497.4,
GN ECO:0000313|VGNC:VGNC:21606};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020497.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020497.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020497.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020497.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020497.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSECAT00000024664.4; ENSECAP00000020497.4; ENSECAG00000022971.4.
DR VGNC; VGNC:21606; PLXNC1.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_004205_0_0_1; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000002281; Chromosome 28.
DR Bgee; ENSECAG00000022971; Expressed in blood and 21 other cell types or tissues.
DR ExpressionAtlas; F6U8I4; baseline.
DR GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:1905806; P:regulation of synapse pruning; IEA:Ensembl.
DR CDD; cd00102; IPT; 2.
DR CDD; cd12789; RasGAP_plexin_C1; 1.
DR CDD; cd11246; Sema_plexin_C1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR041853; Plexin-C1_Sema.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF4; PLEXIN-C1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 2.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 2.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1566
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040497865"
FT TRANSMEM 944..964
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1083..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..452
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1566 AA; 175567 MW; EFA0D3312D33BF01 CRC64;
MEVSRRKAPP RPPRPAAPLP LLAYLLALTV PGRGADEPVW RSEQAIGAIA ASLADGVFVA
SGSCLDQLDY SLEHSLSRLY RDQVGNCTEP VSLAPPVRPR PGSSFSKLLL PYREGAGSPG
GLLLTGWTFD RGACEVRHLG NLSRGSLRNG TEVVSCHPQG STAGVVYRVG NTNRWYLAVA
ATYVLPEPKT ASRCNPAASD RDTAIALKDT EVRSLATQEL GRLKLRLGAG SLHFVDAFLW
NGSVYFPYYP YNYTSGAATG WPSMARIAQS ADVQFQGQAA LDCGHGHPDG RRLLLSSSLV
EALDVWAGVF SAATGESQER RSPATTALCL FRMSEIQARA AESCSGDFES DQNCKEGEQP
ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL KVILGENLTS NCPEVIYEIK
EETPVFYKLI PHPKKNIYIY LTAGKEVRRI PVANCSKHKS CSACLTVSDP HCGWCHSLQR
CTFKEDCVDL QNSENWLDIS SGAKECPQIH MFRGSKNKTT VTVVGNFSPR HSECVVKHVD
STRELCKGKS RGNETCTCNI PTRSPDKDAL VVNVTFSFDA WHLSKRFNFT NCSSLRECAV
CIGTGCAWCK SERRCIHPFR ACDPSDYNRD QTLCQVAVGK WIPPETAGGG RLKENKRDRT
KKGLQVFYVR SIEPQKISTL GKSNVTVTGA NFTQASNITM ILKGTSTCDK DVIQVSHVLN
DTHMKFSLPS SRKEMKDVCI QFDGGNCSSV GPLSYIALPH CSLIFPATTW ISGGQNITIM
GRNFDVIDKL IISHEVPEYC MATYCTFLAP NLKNSKVHPN VTVKLRVQDT YLDCGSLRYL
EDPRFAGYRV EPEGDTELEV RIQKENDNFN ISKKDIEITL FRGKNPPLNC SFENITRNQD
LTTILCKIKG ITAASSIASS SEKVRVKLGN LELFVERESV PSPWYFLIVL PVLLVIVIFA
VGVTRHKSKE LSRKQSQQLE LLESELRKEI RDGFAELQMD KLDVVDSFGT VPFLDYKHFA
LRTFFPESGG FTHIFTEDMH NRDANDKNES LTALDALICN KSFLVTVIHT LEKQKNFSVK
DRCLFASFLT IALQTKLVYL TSILEVLTRD LMEQSSNMQP KLMLRRTESV VEKLLTNWMS
VCLSGFLRET VGEPFYLLVT TLNQKINKGP VDVITCKALY TLNEDWLLWQ VPEFSTVALN
VVFEKIPENE SADVCRNISV NVLDCDTIGQ AKEKIFQAFL SKNGSPYGLQ LNEIGLELQL
GTRQKELLDI DGSSVILEDG ITKLNTIGHY EISNGSTIKV FKRIANFTSE VEYSEDHCHL
ILPDSEAFQD VQGKRHRGKH KFKVKEMYLT KLLSTKVAIH SVLEKLFRSI WSLPNSRAPF
AIKYFFDFLD AQAENKKITD PDVVHIWKTN SLPLRFWVNI LKNPQFVFDI KKTPHIDGCL
SVIAQAFMDA FSLTEQQLGK EAPTNKLLYA KDIPTYKDEV KSYYRAIREL PPLSSSEMEE
FLTQESKKHE NEFNEEVALT EIYKYIVKYF DEILNKLERE RGLEEAQKQL LHVKVLFDEK
KKCKWM
//
