GenomeNet

Database: UniProt
Entry: F6U9C3_HORSE
LinkDB: F6U9C3_HORSE
Original site: F6U9C3_HORSE 
ID   F6U9C3_HORSE            Unreviewed;      4850 AA.
AC   F6U9C3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSECAP00000013079};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSECAP00000013079};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013079, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013079, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013079,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013079}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013079};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000013079}.
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DR   PaxDb; F6U9C3; -.
DR   Ensembl; ENSECAT00000016208; ENSECAP00000013079; ENSECAG00000013267.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000013267; -.
DR   ExpressionAtlas; F6U9C3; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4163   4187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4391   4411       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4459   4478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4590   4608       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4651   4672       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4731   4754       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      568    779       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      995   1191       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1237   1448       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3898   3933       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4850 AA;  550040 MW;  9079E2684D4D1626 CRC64;
     EDEVVLQCIA NVHKEQRKFC LAAEGLGNRL CFLEPTSEAK YVPPDLCVCN FVLEQSLSVR
     ALQEMLANTG ENGGEGAAQG GGHRTLLYGH AILLRHSFSG MYLTCLTTSR SQTDKLAFDV
     GLREHATGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVF SERYLHLSIS NGNIQVDASF
     MQTLWNVHPT CSGSSIEEGY LLGGHVVRLF HGHDECLTIP STDQNDSQHR RVFYEAGGAG
     TRARSLWRVE PLRISWSGSN IRWGQAFRLR HLTTGHYLAL TEDQGLILQD RGKSDTKSTA
     FSFRASKEIK EKLDSSHKRD IEGMGVPEIK YGDSVCFVQH VSSGLWVTYK AQDAKTSRLG
     PLKRKVILHQ EGHMDDGLTL QRCQQEESQA ARIIRNTTAL FSQFVSGNNR TTAPVTLPIE
     EVLQTLQDLI AYFQPPEEEM QHEDKQNKLR SLKNRQNLFK EEGMLALVLN CIDRLNIYNS
     VAHFAGIARE ESGMAWKEIL NLLYKLLAAL IRGNRNNCAQ FSNNLDWLIS KLDRLESSSG
     ILEVLHCILI ESPEALNLIA EGHIKSIISL LDKHGRNHKV LDVLCSLCLC NGVAVRANQN
     LICDNLLPRR NLLLQTRLIN DVTSIRPNIF LGVAEGSAQY KKWYFELIID QVDPFLTAEP
     THLRVGWASS SGYAPYPGGG EGWGGNGVGD DLYSYGFDGL HLWSGRIPRA VASINQHLLK
     SDDVVSCCLD LGVPSISFRI NGQPVQGMFE NFNTDGLFFP VVSFSAGVKV RFLMGGRHGE
     FKFLPPTGYA PCYEALLPKE KMRLEPVKEY KRDAEGVRDL LGTTQFLSQA SFIPCPIDTS
     QVVLPPHLEK IRDRLAENIH ELWGMNKIEL GWTFGKIRDD NKRQHPCLVE FSKLPETEKN
     YNLQMSTETL KTLLALGCHI AHVNPAAEED LKKVKLPKNY MMSNGYKPAP LDLSDVKLLP
     PQEILVDKLA ENAHNVWAKD RIKQGWTYGI QQDLKNKRNP RLVPYALLDE RTKKSNRDSL
     REAVRTFVGY GYNIEPSDQE LADPAVEKVS IDKIRFFRVE RSYAVRSGKW YFEFEVVTGG
     DMRVGWARPG CRPDVELGAD DQAFVFEGSR GQRWHQGSGY FGRTWQPGDV VGCMINLDDA
     SMIFTLNGEL LITNKGSELA FADYEIENGF VPICSLGLSQ IGRMNLGMDA STFKFYTMCG
     LQEGFEPFAV NMNRDVAMWF SKRLPTFVNV PKDHPHIEVV RIDGTMDSPP CLKVTHKTFG
     TQNSNANMIY CRLSMPVECH ASFSHSPCLD SDAFQKRKQM QEILSHTTTC YYTIRIFAGQ
     DPSCVWVGWV TPDYHLYSEK FDLNKNCTVT VTLGDERGRV HESVKRSNCY MVWGGDIVAT
     SQRSSRSNVD LEIGCLVDLA MGMLSFSANG RELGTCYQVE PNTKVFPAVF LQPTSTALFQ
     FELGKLKNAM PLSAAIFKSE EKNPVPQCPP RLDIQTIQPV LWSRMPNSFL KVETERVSER
     HGWVVQCLEP LQMMALHIPE ENRCVDILEL CEQEDLMLFH YHTLRLYSAV CALGNSRVAY
     ALCSHVDLSQ LFYAIDNKYL PGLLRSGFYD LLISIHLASA KERKQMMKNE YIIPITSSTG
     KIRLYPDESK RHGLPGVGLR TCLKPGFRFS TPCFVVTSEE HQKQSPEIPL EILKTKALSM
     LTEAVQCSGA HIRDPVGGSV EFQFVPVLKL IGTLLVMGVF DDDSVRQILL LIDPSVFGEH
     SGEMEEGAEK EEVTQVEEKA VEAGEKASKE APVKGLLQTR LPESVKLQMC ELLSYLCDCE
     LQHRVEAIVA FGDIYVSKLQ ANQKFRYNEL MQALNMSAAL TARKTREFRS PPQEQINMLL
     NFQLGENCPC PEEIREELYD FHEDLLIHCG VPLEEEEEEE EDTSWTGKLR ALVYKIKGPP
     KPEKELPTEE EERCPTTLKE LISQTMIRWA QEDQIQDAEL VRMMFNLLRR QYDSIGELLQ
     ALRKTYTISQ ASVSDTINLL AALGQIRCLL SVRMGKEEEL LMINGLGEIM NNKVFYQHPN
     LMRVLGMHET VMEVMVNVLG AEKSQIAFPK MVASCCRFLC YFCRISRQNQ KAMFEHLSYL
     LENSSVGLAS PSMRGFTPLD VAASSVMDNN ELALGLEEPD LEKVVTYLAG CGLQSCPMLL
     AKGYPDVGWN PIEGERYLSF LRFAVFVNSE SVEENASVVV KLLIRRPECF GPALRGEGGN
     GLLAAMQGAI KISENPALDL PSQGYKREVS TEDAEDDEIV HMGNAIMSFY SALIDLLGRC
     APEMHLIQTG KGEAIRIRSI LRSLVPTEDL VGIISIPLKL PSLNKDGSVS EPDMAANFCP
     DHKAPMVLFL DRVYGIKDQT FLLHLLEVGF LPDLRASASL DTVSLSTTEA ALALNRYLCS
     AVLPLLTRCA PLFAGTEHYT SLIDSTLQTI YRLSKGRSLT KAQRDTIEEC LLAICNHLRP
     SMLQQLLRRL VFDVPQLNEY CKMPLKLLTN HYEQCWKYYC LPSGWGSYGL AVEEELHLTE
     KLFWGIFDSL SHKKYDQDLF RMALPCLSAI AGALPPDYLD TRISATLEKQ VSVDADGNFD
     PKPINTVNFS LPEKLEYIVT KYAEHSHDKW ACDKSLNRWK YGISLDENVK THPLIRPFTL
     TEKEKEIYRW PARESLKTML AVGWTIERTK EGEALVQQRE NEKLRSVSQA SQGNSYSPAP
     LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG GSHPLLVPYD TLTAKEKFRD
     REKAQDLFKF LQVNGIVVSR GMKDMELDAS SMEKRFAYKF LKKILKYVDS AQEFIAHLEA
     IVSSGKTEKS PHDQEIKFFA KVLLPLVDQY FTNHRLYFLS SPLKPLSSSG YASHKEKEMV
     ASLFCKLAAL VRHRISLFGN DSTTMVSCLH ILAQTLDTRT VMKSGSELVK AGLRAFFENA
     AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI LTSIFEHVAQ HQFGVDLLLG
     DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA AIPVAFLEPT LNRYNPLSVF
     NTKTPRERSI LGMPDTVEEM CPDVPQLEGL MKEINDLAES GARYTEMPHV IEVILPMLCN
     YLSYWWERGP EHLPPSTGPW CTKVTSEHLS VTLGNILKII NNNLGIDEAS WMKRIAVYAQ
     PIISKARPGL LRSHFLPTLE KLKKKAVKTV QEEEQLKADS KGDTQEAELL ILDEFAVLCR
     DLYAFYPMLI RYVDNNRSNW LKSPDAYSDQ LFRMVAEIFI LWCKSHNFKR EEQNFVIQNE
     INNLAFLTGD SKSKMSKAMQ VKSGGQDQER KKTKRRGDLY SIQTSLIVAA LKKMLPIGLN
     MCTPGDQELI SLAKSRYSYK DTDEEVKEHL RNNLHLQEKS DDPAVKWQLN LYKDVLKSEE
     PSNPEKTVER VQRISAAVFH LEQVEQPLRS KKAVWHKLLS KQRKRAVVAC FRMAPLYNLP
     HRSINLFLHG YQRFWIETEE YSFEEKLVQD LAKSPKVEEE EEEETEKQPD PLHQIILHFS
     RNALTERSKL EDDPLYTSYS SMMAKSCQSG EEEEEEEDKE KTFEEKEMEK QKTLYQQARL
     HERGAAEMVL QMISASKGEM SPMVVETLKL GIAILNGGNA GVQQKMLDYL KEKKDAGFFQ
     SLSGLMQSCS VLDLNAFERQ NKAEGLGMVT EEGTLIVRER GEKILQNDEF TRDLFRFLQL
     LCEGHNSDFQ NFLRTQMGNT TTVNVIISTV DYLLRLQESI SDFYWYYSGK DIIDESGQHN
     FSKALAVTKQ IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ MKLSQDSSQI
     ELLKELLDLL QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE SSTNVEMILK FFDMFLKLKD
     LTSSDTFKEY DPDGKGIISK KEFQKAMEGQ KQYIQSEIDF LLSCAEADEN DMFNYIDFVD
     RFHEPAKDIG FNVAVLLTNL SEHMPNDSRL KSLLDPAESV LNYFEPYLGR IEIMGGAKKI
     ERVYFEISES SRTQWEKPQV KESKRQFIFD VVNEGGEQEK MELFVNFCED TIFEMQLASQ
     ISESDSADRP EEEEQAEEDS SYMLEIEGEE EDDRSFESVS AFAMACASVR RNVANFLKRA
     TLKNLRKQYR KVKKMTVKEL VKVFFSFFWT LFVGLFQLFF TILGGIFQIL WNTVFGGGLV
     EGAKNIRVTK ILGDMPDPTQ FGIHDDALEA ERAEVTEPGI ATELVYFVKG EKGDADIMSD
     LFGYHSKKES GLKHGPEVGL GDLSEIIGKD EPPTLESAVQ KKRKAQAAEM KAAHEAEGKV
     ESEKADMEDG EKEDTAKEEV QAEALWAEAT KKKKRRCGQK VEKPEAFMAN FFKGLEIYQT
     KLLHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLEE ETEDVANLWN SFNDEEEEEA
     MVFFVLQEST GYMAPTLRAL AIIHTIISLV CVVGYYCLKV PLVVFKREKE IARKLEFDGL
     YITEQPSEDD IKGQWDRLVI NTPSFPNNYW DKFVKRKVIN KYGDLYGAER IAELLGLDKS
     ALDFSPVEET KAEAASLVSW LSSIDMKYHI WKLGVVFTDN SFLYLAWYTT MSVLGHYNNF
     FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE
     DDDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD PYEMYRIVFD ITFFFFVIVI
     LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGNDY FDTTPHGFET HTLQEHNLAN
     YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC FRKQYEDQLG
//
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