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Database: UniProt
Entry: F6UA28_ORNAN
LinkDB: F6UA28_ORNAN
Original site: F6UA28_ORNAN 
ID   F6UA28_ORNAN            Unreviewed;      4822 AA.
AC   F6UA28;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   30-AUG-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSOANP00000016317};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSOANP00000016317};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016317, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000016317}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016317};
RX   PubMed=8919867; DOI=10.1007/BF02198841;
RA   Janke A., Gemmell N.J., Feldmaier-Fuchs G., von Haeseler A., Paabo S.;
RT   "The mitochondrial genome of a monotreme--the platypus
RT   (Ornithorhynchus anatinus).";
RL   J. Mol. Evol. 42:153-159(1996).
RN   [2] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [3] {ECO:0000313|Ensembl:ENSOANP00000016317}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016317};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000016317}.
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DR   Ensembl; ENSOANT00000016320; ENSOANP00000016317; ENSOANG00000010281.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000010281; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4460   4479       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4596   4617       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4654   4675       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4730   4753       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      108    163       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      170    215       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      223    278       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      284    341       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      349    406       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1026   1223       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3911   3946       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4822 AA;  543559 MW;  B4DE1207CC9F2182 CRC64;
     MEKGWNEKPD VRSKDDEVVL QCTTTIHKEQ QKLCLAAEGF GNRLCFLEST SNSKNVPPDL
     SICTFVLEQS LSVRALQEML ANTVEKAEGQ VDLEKWKFMM KTAQGGGHRT LLYGHAILLR
     HSYSGMYLSC LSTTRSSTDK LAFDVGLQED TTGEACWWTI HPASKQRSEG EKVRVGDDLI
     LVSVSSERYL HLSYGNGTLH VDAAFQQTLW SVAPISSGSE AAQGYLIGGD VLRLLHGHMD
     ECLTVPSGEH GEGQRRTVHY EGGAVSIHAR SLWRLETLRV AWSGSHIRWG QPFRLRHITT
     GKYLSLMEDK SLLLMDKEKA DVKSTAFCFR SSKEKLDLGM RKEVEGMGTS EIKYGDSVCF
     IQHADTGLWL TYQSADAKSV RMGSIQRKAI MHHEGHMDDG LNLSRSQHEE SRTARVIRST
     AFLFNRFLRG LEALSKKSKS SPVDLPIESV SLSLQDLIGY FHPPDEHLEH EDKQNRLRAL
     KNRQNLFQEE GVISLVLECI DRLHVYSSAA HFADAAGPEA GDAWKSTLNS LYELLAALIR
     GNRKNCAQFS GSLDWLISRL ERLEASSGIL EVLHCVLVES PEALNIIKEG HIKSIISLLD
     KHGRNHKVLD VLCSLCVCHG VAVRSNQHLI CDNLLPGRDL LLQTRLVNHV SSMRPNVFLG
     ISEGSAQYRK WYYELIVDHA EPFVTAEATH LRVGWASTEG YSPYPGGGEE WGGNGVGDDL
     FSYGFDGLHL WSGCIARTVS SPNQHVLRTE DVVSCCLDLS APSVSFRING QPVQGMFENF
     NVDGLFFPVV SFSAGIKVRF LLGGRHGEFK FLPPPGYAPC FEAVLPKEKL KVENSGEYKQ
     DQNSTRGVRD LLGPTASLPQ AAFTPIPVDT SQVVLSPHLE RIREKLAENI HELWVMNKVE
     LGWQYGPVRD DNKRQHPCLV EFAKLPEQER NYNLQMSLET LKTLLALGCH VGISDERAEE
     KVKKLKLPKN YQLSSGYKPA PMDLSFIKLT ASQEAMVDKL AENAHNVWAR DRIRQGWTYG
     IQQDVKNRRN PRLVPYALLD DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHATRTEASS
     GPGERFRIFR AEKTYAVKAG RWYFEFEAVT AGDMRVGWSR PGCQPDQELG SDEHAFAFDG
     FKAQRWHQGN EHYGRAWQAG DVVGCMVDMN ERTLMFTLNG EILLDDSGSE LAFKDFEVGQ
     GFIPVCSLGL AQVGRMNFGK DVSTLKYFTI CGLQEGYEPF AVNTNRDITM WLSKRLPQFL
     QVPADHEHIE VCLPLGGVRG RIGPRGRRRP GRRGGLGRTV QNGGPRMGGS KMGARPGVAR
     LGRGGGGAVS YSSIQFHGPA TRLYVWNTGH WDISRTRSGE ETCCVPLATL HELRGRLRSH
     MGSPGQGRNN NGLEIGCVVD VATGLLTFTA NGKELSTYYQ VEPSTKLFPA VFAQATSPNV
     FQFELGRIKG AWFVTIGVIH SGDGGYPVRV PHSPFQARLH LLLKSLLLPR ASPRQLGLVA
     RTGRSVVSME RFLPRGSCAL ATVVRSIDIL ELSEQEDLLK FHSHTLRLYS AVCALGNNRV
     AHALCSHVDE QQLLYAIENK YMPGWLRAGY YDLLVDIHLS PYATARLMMN GEFIVPMTEE
     TKITLFPGSG RKHGLPGIGL STSLRPRMRT AAPGFVAVGH EGHQLSPEFP LDVLKAKTIR
     MLTEVREGGL RARDPVGGTT EFLFVPLIKL FYTLLIMGVF HDGDLKHVLR LIEPGVFREA
     AAPDGGARED GDPGGDPGVG AEEMPQDLLQ MKLPEPFKLQ MCLLLQYLCD CQVRHRIEAI
     VAFSDDFVAK LQDNQRFRYN EVMQALNMSA ALTARKTREF RSPPQEQINM LLNFKDEKSE
     CPCPEEIRDQ LLEFHEDLMM HCGIELDEDG GPEGSSDLTI GRLLYLVEKV TYLKKKQAQR
     PVDGYSRKPS TLQQLISETM VRWAQESVME DPELVRAMFV LLHRQYDGIG GLARALPKTY
     TINGVSVEDT VNLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG
     MHETVMEVMV NVLGGGEMKE IIFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS
     VGLASPAMRG STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLLS CPLLVSKGYP
     DVGWNPVEGE RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA
     MEEAIKIAED PSRDGPSPAN GAGRTLEVEE EDDTIHMGNA IMTFYAALID LLGRCAPEMH
     LIHAGKGEAI RIRSILRSLI PLGDLVGVIS IAFQMPTIAK DGNVVEPDMS AGFCPDHKAA
     MVLFLDRVYG IEVQDFLLHL LEVGFLPDLR AAASLDTAAL SATDMALALN RYLCTAVLPL
     LTRCASLFAG TEHHASLIDS LLHTVYRLSK GCSLTKAQRD SIEVCLLSIC GQLRPPMMQH
     LLRRLVFDVP LLNEHSKMPL KLLMNHYERC WKYYCLPGGW GSFGTASEEE LHLSRKLFWG
     IFDALSQKKY EQELFKLALP CLSAVGGALP PDYMESNYVS MMEKQSSMDS EGNFNPQPVD
     TSNITIPEKL EYFINKYAEH SHDKWSMEKL ANGWIYGEIY SDSSKVQPLM KPYKLLSEKE
     KEIYRWPIKE SLKTMLAWGW RIERTREGDS MAFYNRTRRI SQTSQVSVDA AHGYSPRAID
     MSNVTLSRDL HAMAEIMAEN YHNIWAKKKK MELEAKVGGG NHPLLVPYDT LTAKEKAKDR
     EKAQDILKFL QINGYTVSRG FKDLEMDTPS IEKRFAYSFL QQLIRYVDAA HQYILEFDGG
     SRSKGEHFPY EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLSTGGHA SNKEKEMVTS
     LFCKLGVLVR HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGMESVKAA LRAFLENAAK
     DLEKTMENLK QGQFTHTRSQ PKGVTQIINY TTVALLPMLS SLFEHIGQLQ FGEDLILEDV
     QVSCYRILSS LYALGTSKSI YVERQRSALG ECLAAFAGAF PVAFLETSLN QHNPYSIYNT
     KTPRERAALN LPDSVEEMCP GVPTLEKLME EIMELAESGV RYAQMPHVME VILPMLCSYM
     SRWWEYGPEG RPQPAPPAEP CCIPCCTALR SDHMNTLLGN VLKIIHNNLG VDEGAWMKRL
     AVFSQPIINK VKSQLLKTHF LPLMAKLKKK AATVVSDEDH LKAEARGDMS EAELLILDEF
     TTLARDLYAF YPLLIRFVDY NRAKWLKEPN PEAEELFRMV AEVFIYWSKS HNFKREEQNF
     VVQNEINNMS FLITDTKSKM SKAAVSDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN
     VCAPGDQELI ALAKNRFSLK DTEDEVRDVI RSNLHLQGKM EDPAIRWQMA LYKDLPHRTD
     GASDPEKTVE RVLDIANVLF HLDQKPTYMG RRYYSMGSTE LNCVEHPQRS KKAVWHKLLS
     KQRKRAVVAC FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE EHYFEDKLIE DLAKPGTEPP
     EEDEASRRVD PLHQLILLFS RTALTEKCKL EEDFLYMAYA DIMAQSCHDE EDDSGEEEVK
     SFEEKEMEKQ KLLYQQARLH ERGAAEMVLQ TISAGKGDTG PMVAATLKLG IAILNGGNST
     VQQKMLDYLK EKKDVGFFQS LAGLMQSCSV LDLNAFERQN KAEGLGMVTE EGSGEKVLQD
     DEFTCDLFRF LQLLCEGHNS DFQNYLRTQT GNNTTVNIII STVDYLLRVQ ESISDFYWYY
     SGKDVIDEQG QRNFSKAIQV AKQVFNTLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA
     HMQMKLSQDS SQIELLKELM DLQKDMVVML LSMLEGNVVN GTIGKQMVDM LVESSNNVEM
     ILKFFDMFLK LKDLTSSDAF KEYDPDSKGV ISKRDFHKAM ESHKHYTQSE TEFLLSCAET
     DENETLDYEE FVKRFHEPAK DIGFNVAVLL TNLSEHMPND TRLQTFLELA ESVLNYFQPF
     LGRIEIMGSA KRIERVYFEI SESSRTQWEK PQVKESKRQF VFDVVNEGGE KEKMELFVSF
     CEDTIFEMQL AAQISDLLTL FLSADLFQEQ KKAQGDKDEK EEMKSEPEKA EYVELYAVIF
     FASFFPSHIS SLVRSSWELG TFPAQKARGS NPGSATRLLC DFGQVTFIHS FIQSYLLSAY
     CVQSTVLSAW KVRFSDTERG NPCPPRVYKT VGDEEFSGVP LVGKFNQSTL IEISDSFSQS
     YLLSAYCDGY GLGARRKGAA CRHITSPSAA TGDLMNSLGG RPGQLPATDC LPVDDAGVLS
     VSDFLRSPRG EDGEKEEKGR DEKGKQKLRQ LHAHRYGEPE TQESAFWKKI IAYQQKLLNY
     FARNFYNMRM LALFVAFAIN FILLFYKVST SSATEGKEFS IPSVSEDTGL DSLDGPSHRI
     ITVHFVLEES SGYMEPTLRI LAILHTVISF FCIIGYYCLK VPLVIFKREK EVARKLEFDG
     LYITEQPSED DIKGQWDRLA INTQSFPNNY WDKFVKRKVM DKYSEFYGRD RISELLGMDK
     AALDFSDARE KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF TDNSFLYLAW YMTMSVLGHY
     NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN
     KSEDGDMPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP AGDEYEIYRI IFDITFFFFV
     IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG NDYFDTVPHG FETHTLQEHN
     LANYLFFLMY LINKDETEHT GQ
//
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