ID F6UA59_MONDO Unreviewed; 1037 AA.
AC F6UA59;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Importin 9 {ECO:0000313|Ensembl:ENSMODP00000000574.3};
GN Name=IPO9 {ECO:0000313|Ensembl:ENSMODP00000000574.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000000574.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000000574.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000000574.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_001368702.1; XM_001368665.3.
DR AlphaFoldDB; F6UA59; -.
DR STRING; 13616.ENSMODP00000000574; -.
DR Ensembl; ENSMODT00000000589.4; ENSMODP00000000574.3; ENSMODG00000000485.4.
DR GeneID; 100014391; -.
DR KEGG; mdo:100014391; -.
DR CTD; 55705; -.
DR eggNOG; KOG2274; Eukaryota.
DR GeneTree; ENSGT00390000008224; -.
DR HOGENOM; CLU_008920_0_0_1; -.
DR InParanoid; F6UA59; -.
DR OMA; NPDQYTI; -.
DR OrthoDB; 2908261at2759; -.
DR TreeFam; TF323706; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000000485; Expressed in hindlimb bud and 19 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0140713; F:histone chaperone activity; IEA:Ensembl.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0031144; P:proteasome localization; IEA:Ensembl.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR PANTHER; PTHR10997:SF9; IMPORTIN-9; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 41..117
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 932..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..961
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1037 AA; 115585 MW; C2F1044DB6F3D205 CRC64;
MAAAAGAGSG LPGPVAQGLK EALVETLTGI LSPVQEVRAA AEEQIKVLEV TEEFGVHLAE
LTVDPQGALA IRQLASVILK QYVETHWCAQ SEKFRPPETT ERAKVVIREL LPNGLRESIS
KVRSSVAYAV SAIAHWDWPE AWPQLFNLLM EMLVSGDLNA VHGAMRVLTE FTREVTDTQM
PLVAPVILPE MYKIFTMAEV YGIRTRSRAV EIFTTCAHMI CNMEELEKGA AKVLIFPVVQ
QFTEAFVQAL QMPDGPTSDS GFKMEVLKAV TALVKNFPKH MVSSMQQILP IVWNTLTESA
AFYVRTEVNY TEEVEDPVDS DGEVLGFENL VFSIFEFVHA LLENSKFKST VKKALPELIY
YIILYMQITE EQIKVWTANP QQFVEDEDDD TFSYTVRIAA QDLLLAVATD FQNESATALA
AAATRHLQEA EQTQSSGTEH WWKIHEACML ALGSVKSIIT DNVKNGRVHF DMHGFLTNVV
LADLNLSVSP FLLGRALWAA SRFTVAMSPE LIQQFLQATV SGLHETQPPS VRISAVRAIW
GYCDQLKVSE STHVLRPFLP SVLDGLIHLA AQFSSEVLNL VMETLCIVST VDPEFTASVE
NKICPFTIAI FLKYSNDPVV ASLAQDIFKE LAQIEACQGP MQMRLIPTLV SIMQAPADKI
PAGLCATAID ILTTVVRNTK PPLSQLLICQ AFPAVAQCTL NTDDNATMQN GGECLRAYVS
VALEQIAQWH DEQGHNGLWY VMQVVSQLLD PRTSEFTAAF VGRLVSTLIS KAGRELGENL
DQILRAILSK MQQAETLSVM QSLIMVFAHL VHTQLEPLLE FLCSLPGPTG KPALEFVMAE
WTSRQHLFYG QYEGKVSSVA LCKLLQHGIN ADDKRLQDIR VKGEEIFNMD EGIRTRSKAA
KNPERWTNIP LLVKILKLII NELSNVMEAN ASRQTPAEWS QDDSNDMWED QEEEEEEDEG
LAGQLLSDIL ASNKYDEDYY EDDEEDDPDA LKDPLYQVDL QAYLTDFLCQ FAQQPCYLMF
SGHLNDNERR VLHTIGI
//
